Volume 36, No 2, Feb 2026

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 36 Issue 2, February 2026: 95-96

RESEARCH HIGHLIGHTS

Fibrous-layer periosteal stem cells sensing injury-induced inflammation

Noriaki Ono^*

University of Texas Health Science Center at Houston School of Dentistry, Houston, TX, USA
Correspondence: Noriaki Ono(noriaki.ono@uth.tmc.edu)

Periosteum is indispensable for bone fracture healing — but where exactly are its stem cells located? A study by Jiang et al. identifies angiopoietin-like 7 (Angptl7)-expressing skeletal stem cells in the fibrous layer of the murine periosteum; these cells remain quiescent under homeostasis but are rapidly activated in response to injury-induced inflammation, orchestrating endochondral ossification.

https://doi.org/10.1038/s41422-025-01210-8

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