Volume 36, No 3, Mar 2026

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 36 Issue 3, March 2026: 173-174

RESEARCH HIGHLIGHTS

Boosting immunotherapy by restoring cryptic APC function

Wonhwa Cho^*

Department of Chemistry, University of Illinois Chicago, Chicago, IL, USA
Correspondence: Wonhwa Cho(wcho@uic.edu)

APC is the most frequently mutated gene in colorectal cancer, which drives tumorigenesis by increasingly more complex mechanisms beyond activation of Wnt-β-catenin signaling. In this issue of Cell Research, Ma et al. reports that APC truncation causes immune suppression by promoting PTPN13-mediated deactivation of STAT1, inhibition of which boosts anti-tumor immunity.

https://doi.org/10.1038/s41422-026-01219-7

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