Volume 36, No 4, Apr 2026

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 36 Issue 4, April 2026: 239-240

RESEARCH HIGHLIGHTS

Asymmetric division rejuvenates stem cell lineages

Jianlong Wang^*

Department of Medicine, Columbia Center for Human Development, Columbia Center for Stem Cell Therapies, Columbia Stem Cell Initiative, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA
Correspondence: Jianlong Wang(jw3925@cumc.columbia.edu)

Mouse embryonic stem cells maintain lineage immortality through sporadic entry into a two-cell-like state that enables asymmetric partitioning of DNA damage between daughter cells: one destined for elimination and one functionally rejuvenated.

https://doi.org/10.1038/s41422-026-01226-8

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