Volume 36, No 6, Jun 2026

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 36 Issue 6, June 2026: 385-386

RESEARCH HIGHLIGHTS

Carnitine biosynthesis governs fuel switching

Kyounghee Min , Philipp E. Scherer^*

Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA
Correspondence: Philipp E. Scherer(Philipp.Scherer@UTSouthwestern.edu)

In a recent Science study, Auger and colleagues identified SLC25A45 as a previously unrecognized mitochondrial trimethyllysine (TML) transporter that enables l-carnitine biosynthesis. By regulating mitochondrial TML availability, SLC25A45 links environmental stressors such as cold exposure and fasting to adaptive fuel switching toward fatty acid oxidation, thereby optimizing mitochondrial energetics and metabolic resilience.

https://doi.org/10.1038/s41422-026-01229-5

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