Volume 36, No 5, May 2026

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 36 Issue 5, May 2026: 381-384

LETTERS TO THE EDITOR

Chemical reprogramming directly resets mouse post-implantation epiblast cells to a totipotent state

Hai Zhou^1,† , Xuzhao Zhai^1,2,† , Chikai Zhou^3,† , Junyu Chen^1,2 , Xiukun Wang⁴ , Ling Li¹ , Wenwen Shi¹ , Shu Sun^1,5 , Guokai Chen⁵ , Guang Hu⁴ , Erwei Zuo³ , Man Zhang^1,*

¹GMU-GIBH Joint School of Life Sciences, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, Guangdong, China
²Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China
³Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Key Laboratory of Synthetic Biology, Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, Guangdong, China
⁴Epigenetics and RNA Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
⁵Department of Biomedical Sciences and Centre of Reproduction, Development and Aging (CRDA), Faculty of Health Sciences, University of Macau, Taipa, China
^†These authors contributed equally: Hai Zhou, Xuzhao Zhai, Chikai Zhou
Correspondence: Man Zhang(zhang_man@gzlab.ac.cn)

https://doi.org/10.1038/s41422-026-01244-6

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