Volume 36, No 7, Jul 2026

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 36 Issue 7, July 2026: 471-472

RESEARCH HIGHLIGHTS

Phosphatidylserine exposure and cancer immune evasion

Manuel Beltrán-Visiedo , Kerry S. Campbell , Lorenzo Galluzzi^*

Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, PA, USA
Correspondence: Lorenzo Galluzzi(deadoc80@gmail.com)

Phosphatidylserine (PS) exposure on apoptotic cancer cells promotes their rapid and immunologically silent uptake by phagocytes, therefore favoring immune evasion. In a recent Nature study, evidence from viral infection models suggests that externalized PS also suppresses dendritic cell (DC) activation, adding to an expanding literature that identifies post-mitochondrial caspases as promising targets to inflame immunologically “cold” tumors.

https://doi.org/10.1038/s41422-026-01252-6

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