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Volume 33 Issue 7, Jul 2023

The lotus beneath Nezha, a fairy tale character, represents an ER anion channel CLCC1. Chloride through CLCC1 compensates both potential and osmolality changes during ER Ca2+ release together with K+ (2Ca2++Cl–=3K+). CLCC1 dysfunction leads to imbalance of ER ion homeostasis (2Ca2+=4K+), ER swelling, and neurodegeneration, which is linked with ALS represented by Nezha’s frozen leg and spear. See page 497–515 by Liang Guo et al. for details.

RESEARCH HIGHLIGHTS

Identity revealed for a long-sought ER anion channel

Laura Bianchi
https://doi.org/10.1038/s41422-023-00807-1
Full Text | PDF | Abstract


Transgenerational inheritance of engineered cytosine methylation in mice

Maximilian M. L. Knott, Oded Rechavi
https://doi.org/10.1038/s41422-023-00799-y
Full Text | PDF | Abstract


Precision medicine for metastatic TNBC: the FUTURE is now

Julia Foldi, Charles E. Geyer Jr
https://doi.org/10.1038/s41422-023-00815-1
Full Text | PDF | Abstract


A sticky solution to protein-selective sugar installation

Matthew R. Pratt
https://doi.org/10.1038/s41422-023-00787-2
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RNA editing: new roles in feedback and feedforward control

Xiang-Dong Fu
https://doi.org/10.1038/s41422-023-00834-y
Full Text | PDF | Abstract


ORIGINAL ARTICLES

Disruption of ER ion homeostasis maintained by an ER anion channel CLCC1 contributes to ALS-like pathologies

Liang Guo, Qionglei Mao, Ji He, Xiaoling Liu, Xuejiao Piao, Li Luo, , Hanzhi Yu, Qiang Song, Bailong Xiao, Dongsheng Fan, Zhaobing Gao, Yichang Jia
https://doi.org/10.1038/s41422-023-00798-z
Full Text | PDF | Abstract | Open Access


Antagonizing the irreversible thrombomodulin-initiated proteolytic signaling alleviates age-related liver fibrosis via senescent cell killing

Christopher C. Pan, Raquel Maeso-Díaz, Tylor R. Lewis, Kun Xiang, Lianmei Tan, Yaosi Liang, Liuyang Wang, Fengrui Yang, Tao Yin, Calvin Wang, Kuo Du, De Huang, Seh Hoon Oh, Ergang Wang, Bryan Jian Wei Lim, Mengyang Chong, Peter B. Alexander, Xuebiao Yao, Vadim Y. Arshavsky, Qi-Jing Li, Anna Mae Diehl, Xiao-Fan Wang
https://doi.org/10.1038/s41422-023-00820-4
Full Text | PDF | Abstract


Structure and transport mechanism of the human calcium pump SPCA1

Mengqi Wu, Cang Wu, Tiefeng Song, Kewu Pan, Yong Wang, Zhongmin Liu
https://doi.org/10.1038/s41422-023-00827-x
Full Text | PDF | Abstract | Open Access


Cathepsin B S-nitrosylation promotes ADAR1-mediated editing of its own mRNA transcript via an ADD1/MATR3 regulatory axis

Zhe Lin, Shuang Zhao, Xuesong Li, Zian Miao, Jiawei Cao, Yurong Chen, Zhiguang Shi, Jia Zhang, Dongjin Wang, Shaoliang Chen, Liansheng Wang, Aihua Gu, Feng Chen, Tao Yang, Kangyun Sun, Yi Han, Liping Xie, Hongshan Chen, Yong Ji
https://www.nature.com/articles/s41422-023-00812-4
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LETTERS TO THE EDITOR

Bacterial coinfections contribute to severe COVID-19 in winter

Hui Fan, Li Zhou, Jingjun Lv, Shimin Yang, Guozhong Chen, Xinjin Liu, Chunyan Han, Xue Tan, Shengnan Qian, Zegang Wu, Shan Yu, Ming Guo, Chengliang Zhu, Yu Chen, Ke Lan
https://doi.org/10.1038/s41422-023-00821-3
Full Text | PDF | Abstract


Structure of the SNAPc-bound RNA polymerase III preinitiation complex

Haifeng Hou, Qianwei Jin, Yulei Ren, Zhenguo Chen, Qianmin Wang, Yanhui Xu
https://doi.org/10.1038/s41422-023-00819-x
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CORRIGENDA

Author Correction: Evolutionarily conservative and non-conservative regulatory networks during primate interneuron development revealed by single-cell RNA and ATAC sequencing

Ziqi Zhao, Dan Zhang, Fuqiang Yang, Mingrui Xu, Shaoli Zhao, Taotao Pan, Chuanyu Liu, Yongjie Liu, Qingfeng Wu, Qiang Tu, Ping Zhou, Rong Li, Jia Kang, Lan Zhu, Fei Gao, Yaqing Wang, Zhiheng Xu
https://doi.org/10.1038/s41422-022-00757-0
Full Text | PDF | Abstract | Open Access
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