Cell Research

Volume 34 Issue 9, Sep 2024

The image depicts the Chinese legend "The Magic Brush" ("Shen Bi Ma Liang"). The towering mountain symbolizes the rugged protein fitness landscape, with reaching the summit representing the challenging tasks in protein engineering. Our proposed method, ProMEP, serves as the magic brush, sketching out a rapid path to the peak for biologists. The brush’s handle, adorned with dots, lines, and jewels, signifies the power of artificial intelligence technology driving this journey. See page 630–647 by Peng Cheng et al. for details.

RESEARCH HIGHLIGHTS

Synergizing sequence and structure representations to predict protein variants

Tong Chen, Pranam Chatterjee
https://doi.org/10.1038/s41422-024-01010-6
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Piecing together aminergic polypharmacology

Blake A. Fordyce, Bryan L. Roth
https://doi.org/10.1038/s41422-024-00970-z
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AI accurately predicting the structure of biomolecular interactions

Zhenling Peng, Peilong Lu, Jianyi Yang
https://doi.org/10.1038/s41422-024-00991-8
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DALT: the brain’s border patrol

Jang Hyun Park, Jenolyn F. Alexander, Leon C. D. Smyth, Jonathan Kipnis
https://doi.org/10.1038/s41422-024-00976-7
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ILC2s govern sex-differential immunity in skin

Katie L. Flanagan
https://doi.org/10.1038/s41422-024-00972-x
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Persistent in vivo epigenetic silencing of Pcsk9

Isabella R. Gengaro, Lei S. Qi
https://doi.org/10.1038/s41422-024-00954-z
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REVIEW ARTICLE

Coding, or non-coding, that is the question

Laura Poliseno, Martina Lanza, Pier Paolo Pandolf
https://doi.org/10.1038/s41422-024-00975-8
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ORIGINAL ARTICLES

Zero-shot prediction of mutation effects with multimodal deep representation learning guides protein engineering

Peng Cheng, Cong Mao, Jin Tang, Sen Yang, Yu Cheng, Wuke Wang, Qiuxi Gu, Wei Han, Hao Chen, Sihan Li, Yaofeng Chen, Jianglin Zhou, Wuju Li, Aimin Pan, Suwen Zhao, Xingxu Huang, Shiqiang Zhu, Jun Zhang, Wenjie Shu, Shengqi Wang
https://doi.org/10.1038/s41422-024-00989-2
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SMYD5 is a ribosomal methyltransferase that catalyzes RPL40 lysine methylation to enhance translation output and promote hepatocellular carcinoma

Bisi Miao, Ling Ge, Chenxi He, Xinghao Wang, Jibo Wu, Xiang Li, Kun Chen, Jinkai Wan, Shenghui Xing, Lingnan Ren, Zhennan Shi, Shengnan Liu, Yajun Hu, Jiajia Chen, Yanyan Yu, Lijian Feng, Natasha M. Flores, Zhihui Liang, Xinyi Xu, Ruoxin Wang, Jian Zhou, Jia Fan, Bin Xiang, En Li, Yuanhui Mao, Jingdong Cheng, Kehao Zhao, Pawel K. Mazur, Jiabin Cai, Fei Lan
https://doi.org/10.1038/s41422-024-01013-3
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LETTERS TO THE EDITOR

Combination therapy of KRAS G12V mRNA vaccine and pembrolizumab: clinical benefit in patients with advanced solid tumors

Xinjing Wang, Wei Wang, Siyi Zou, Zhiwei Xu, Dan Cao, Shuai Zhang, Minzhi Wei, Qian Zhan, Chenlei Wen, Fanlu Li, Hao Chen, Da Fu, Lingxi Jiang, Ming Zhao, Baiyong Shen
https://doi.org/10.1038/s41422-024-00990-9
Full Text | PDF | Abstract | Open Access

Structural insights into VAChT neurotransmitter recognition and inhibition

Yang Zhang, Fei Dai, Nanhao Chen, Dong Zhou, Chia-Hsueh Lee, Chen Song, Yixiao Zhang, Zhe Zhang
https://doi.org/10.1038/s41422-024-00986-5
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CORRIGENDA

Author Correction: Structural and functional evidence that GPR30 is not a direct estrogen receptor

Heng Liu, Shimeng Guo, Antao Dai, Peiyu Xu, Xin Li, Sijie Huang, Xinheng He, Kai Wu, Xinyue Zhang, Dehua Yang, Xin Xie, H. Eric Xu
https://doi.org/10.1038/s41422-024-00998-1
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