Cell Research

Volume 35 Issue 10, Oct 2025

The thatched cottage symbolizes the gastruloid formed by human gastrulating stem cells. Its development surges forward like a river. The trees on the bank, the lotus flowers and leaves drifting on the water, and the distant mountains together signify the development of organs arising from the three germ layers within the gastruloid. See page 719–734 by Mingqian Huang et al. for details.

RESEARCH HIGHLIGHTS

Cultured human stem cells undergoing gastrulation

Fan Zhang, Fan Guo
https://doi.org/10.1038/s41422-025-01151-2
Full Text | PDF | Abstract

Osteocalcin has many tricks to get γ-carboxylated

https://doi.org/10.1038/s41422-025-01177-6
Full Text | PDF | Abstract

Novel organoid culture condition: modeling fetal-like plasticity in colorectal cancer

Chao Wu, Min Jung Kim, J. Joshua Smith
https://doi.org/10.1038/s41422-025-01170-z
Full Text | PDF | Abstract

SIX of one and half-a-dozen USP2 regulating inflammation

Lin Liu, John Silke
https://doi.org/10.1038/s41422-025-01173-w
Full Text | PDF | Abstract

Beyond peptide targeting sequences: machine learning of cellular condensate localization

Jonathon A. Ditlev, Julie D. Forman-Kay
https://doi.org/10.1038/s41422-025-01115-6
Full Text | PDF | Abstract

A phytoalexin dismantles bacterial type III injectisome

Manman Zhang, Cheng Li, Zheng Qing Fu
https://doi.org/10.1038/s41422-025-01111-w
Full Text | PDF | Abstract

REVIEW ARTICLE

Lung cell fates during influenza

Brianna Jarboe, Maria Shubina, Ryan A. Langlois, David F. Boyd, Siddharth Balachandran
https://doi.org/10.1038/s41422-025-01163-y
Full Text | PDF | Abstract | Open Access

ORIGINAL ARTICLES

Establishment of human gastrulating stem cells with the capacity of stable differentiation into multiple gastrulating cell types

Mingqian Huang, Mengqi Chen, Gege Yuan, Yiqiang Cui, Bin Shen, Zhaode Liu, Bohang Zhang, Junqing Chen, Dingdong Chen, Shuangshuang Qiu, Yichun Zhang, Li Liu, Lianju Qin, Yunfei Zhu, Jiayin Liu, Hao Zhang, Jun Wu, Yan Yuan, Jiahao Sha
https://doi.org/10.1038/s41422-025-01146-z
Full Text | PDF | Abstract

Structural insights into the vitamin K-dependent γ-carboxylation of osteocalcin

Qing Cao, Jianjun Fan, Aaron Ammerman, Samjhana Awasthi, Zongtao Lin, Saimi Mierxiati, Huaping Chen, Jinbin Xu, Benjamin A. Garcia, Bin Liu, Weikai Li
https://doi.org/10.1038/s41422-025-01161-0
Full Text | PDF | Abstract

AlphaCD: a machine learning model capable of highly accurate characterization for 21,335 cytidine deaminases

Kui Xu, Guoying Hua, Mingdi Wu, Haihang Zhang, Jingda Liu, Hu Feng, Erwei Zuo
https://doi.org/10.1038/s41422-025-01164-x
Full Text | PDF | Abstract

Autism-related proteins form a complex to maintain the striatal asymmetry in mice

Yisheng Jiang, Feipeng Zhu, Jie Zhong, Xiaomei Sun, Yuting Yuan, Shuo Wang, Haiyang Chen, Zhiheng Xu
https://doi.org/10.1038/s41422-025-01174-9
Full Text | PDF | Abstract | Open Access

LETTERS TO THE EDITOR

Structure and activation mechanism of human sweet taste receptor

Haolan Wang, Xiao Chen, Yaxin Dai, Shabareesh Pidathala, Yiming Niu, Chen Zhao, Siyu Li, Liang Wang, Chia-Hsueh Lee
https://doi.org/10.1038/s41422-025-01156-x
Full Text | PDF | Abstract | Open Access

CORRIGENDA

Author Correction: Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4

Chengyang Huang, Yang Xiang, Yanru Wang, Xia Li, Longyong Xu, Ziqi Zhu, Ting Zhang, Qingqing Zhu, Kejing Zhang, Naihe Jing, Charlie Degui Chen
https://doi.org/10.1038/s41422-025-01143-2
Full Text | PDF | Abstract