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Table of Contents

Volume 35 Issue 1, Jan 2025

The dual effects of glucocorticoids (GCs) are illustrated by bees. Left, low levels of GCs bind to the canonical high-affinity GC receptor (GR, the flower producing honey), mediating physiological and therapeutic effects. Right, high levels of GCs can also bind to the low-affinity receptor, tau, leading to bone loss and demonstrating pathological effects. See page 23–44 by Wenyu Fu et al. for details.

RESEARCH HIGHLIGHTS

Tau(t)ing glucocorticoid binding

Sabine Vettorazzi, Jan Tuckermann
https://doi.org/10.1038/s41422-024-01041-z
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Deciphering the role of immune system in the obesity–cancer relationship

Camille Blériot, Gerasimos Anagnostopoulos, Florent Ginhoux
https://doi.org/10.1038/s41422-024-01008-0
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LKB1 inactivation unleashes prostate cancer lineage plasticity

Shaghayegh Nouruzi, Amina Zoubeidi
https://doi.org/10.1038/s41422-024-01030-2
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Immunity hubs orchestrating antiviral defense

Linnan Zhu, Zemin Zhang
https://doi.org/10.1038/s41422-024-01036-w
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NLRC5 PANoptosome: Aquaman of the Dead Sea

Poonam S. Jadhav, Shreya Mahajan, Si Ming Man
https://doi.org/10.1038/s41422-024-01011-5
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REVIEW ARTICLE

Modern biology of extrachromosomal DNA: A decade-long voyage of discovery

Qing-Lin Yang, Yipeng Xie, Kailiang Qiao, Jun Yi Stanley Lim, Sihan Wu
https://doi.org/10.1038/s41422-024-01054-8
Full Text | PDF | Abstract | Open Access


ORIGINAL ARTICLES

Tau is a receptor with low affinity for glucocorticoids and is required for glucocorticoid-induced bone loss

Wenyu Fu, Meng Chen, Kaidi Wang, Yujianan Chen, Yazhou Cui, Yangli Xie, Zi-Ning Lei, Wenhuo Hu, Guodong Sun, Guiwu Huang, Chaopeng He, Jackie Fretz, Aubryanna Hettinghouse, Ronghan Liu, Xianyi Cai, Mingshuang Zhang, Yuehong Chen, Nan Jiang, Minchun He, Daniel H. Wiznia, Huiyun Xu, Zhe-Sheng Chen, Lin Chen, Kanglai Tang, Hong Zhou, Chuan-Ju Liu
https://doi.org/10.1038/s41422-024-01016-0
Full Text | PDF | Abstract | Open Access


Reducing functionally defective old HSCs alleviates aging-related phenotypes in old recipient mice

Yuting Wang, Wenhao Zhang, Chao Zhang, Hoang Q. Tran Van, Takashi Seino, Yi Zhang
https://doi.org/10.1038/s41422-024-01057-5
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LKB1 inactivation promotes epigenetic remodeling-induced lineage plasticity and antiandrogen resistance in prostate cancer

Fei Li, Pengfei Dai, Huili Shi, Yajuan Zhang, Juan He, Anuradha Gopalan, Dan Li, Yu Chen, Yarui Du, Guoliang Xu, Weiwei Yang, Chao Liang, Dong Gao
https://doi.org/10.1038/s41422-024-01025-z
Full Text | PDF | Abstract | Open Access


LETTERS TO THE EDITOR

α-Synuclein amyloid fibril directly binds to LC3B and suppresses SQSTM1/p62-mediated selective autophagy

Qianhui Xu, Huilan Wang, Ruonan Yang, Youqi Tao, Ziying Wang, Shengnan Zhang, Bo Sun, Dan Li, Boxun Lu, Cong Liu
https://doi.org/10.1038/s41422-024-01022-2
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Structural insight into GPR55 ligand recognition and G-protein coupling

Ruixue Xia, Qingning Yuan, Na Wang, Li Hou, Junpei Abe, Jing Song, Yukishige Ito, H. Eric Xu, Yuanzheng He
https://doi.org/10.1038/s41422-024-01044-w
Full Text | PDF | Abstract | Open Access


Structure basis of ligand recognition and activation of GPR55

Hao Chang, Xiaoting Li, Ling Shen, Xuanrui Ge, Shuming Hao, Lijie Wu, Shenhui Liu, Junlin Liu, Vadim Cherezov, Tian Hua
https://doi.org/10.1038/s41422-024-01046-8
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CORRIGENDA

Correction: Sanofi-Cell Research outstanding paper award of 2023

Cell Research Editorial Team
https://doi.org/10.1038/s41422-024-01062-8
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