RESEARCH HIGHLIGHTS

Self-RNA Rmrp pre-dimerizes TLR3 for immune activation

Ailin Han, Richard A. Flavell
https://doi.org/10.1038/s41422-025-01184-7
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Deconstructing the architecture of memory engrams

Yi Zhong, Bo Lei
https://doi.org/10.1038/s41422-025-01179-4
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LGP2 stops MDA5 translocation to start antiviral signaling

Jiyoung Jang, Myung Hyun Jo
https://doi.org/10.1038/s41422-025-01187-4
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Niche-generated taurine is leukemic fuel

Christina Mayerhofer, David T. Scadden
https://doi.org/10.1038/s41422-025-01136-1
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Why resident microglial-like cells were missed in the peripheral nervous system

Michal Schwartz
https://doi.org/10.1038/s41422-025-01119-2
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Selective CDK4 inhibition holds promise for breast cancer

Manuel Beltrán-Visiedo, Rebecca M. Shulman, Lorenzo Galluzzi
https://doi.org/10.1038/s41422-025-01117-4
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REVIEW ARTICLE

Trained immunity: induction of an inflammatory memory in disease

Titus Schlüter, Yuri van Elsas, Bram Priem, Athanasios Ziogas, Mihai G. Netea
https://doi.org/10.1038/s41422-025-01171-y
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Lineage plasticity and histological transformation: tumor histology as a spectrum

Xiaoling Li, Eric E. Gardner, Sonia Molina-Pinelo, Clare Wilhelm, Ping Mu, Álvaro Quintanal-Villalonga
https://doi.org/10.1038/s41422-025-01180-x
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ORIGINAL ARTICLES

Molecular characterization of endosomal self RNA Rmrp-engaged TLR3 dimerization to prime innate activation

Shikun Zhang, Bo Li, Lun Liu, Dongsheng Gong, Deyu Zhang, Fengjiang Liu, Xiuna Yang, Hua Qin, Deling Kong, Shuyang Zhang, Zihe Rao, Xuetao Cao
https://doi.org/10.1038/s41422-025-01178-5
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Soluble tissue factor generated by necroptosis-triggered shedding is responsible for thrombosis

Peixing Wan, Swati Choksi, Yeon-Ji Park, Xin Chen, Jiong Yan, Sahar Foroutannejad, Zhaoshan Liu, Jichun Chen, Ross Lake, Chengyu Liu, Zheng-Gang Liu
https://doi.org/10.1038/s41422-025-01167-8
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Targeting necrotic lipid release in tumors enhances immunosurveillance and cancer immunotherapy of glioblastoma

Yapeng Ji, Junyao Jiang, Lei Hu, Peng Lin, Mingshan Zhou, Song Hu, Minkai Wang, Yuchen Ji, Xianzhi Liu, Dongming Yan, Yang Guo, Adwait Amod Sathe, Bret M. Evers, Chao Xing, Xuelian Luo, Qi Xie, Weike Pei, Zhenyu Zhang, Hongtao Yu
https://doi.org/10.1038/s41422-025-01155-y
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Mechanisms of KCNQ1 gating modulation by KCNE1/3 for cell-specific function

Chenxi Cui, Lu Zhao, Ali A. Kermani, Shuzong Du, Tanadet Pipatpolkai, Meiqin Jiang, Sagar Chittori, Yong Zi Tan, Jingyi Shi, Lucie Delemotte, Jianmin Cui, Ji Sun
https://doi.org/10.1038/s41422-025-01152-1
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Secondary structure transitions and dual PIP2 binding define cardiac KCNQ1-KCNE1 channel gating

Ling Zhong, Xiaoqing Lin, Xinyu Cheng, Shuangyan Wan, Yaoguang Hua, Weiwei Nan, Bin Hu, Xiangjun Peng, Zihan Zhou, Qiansen Zhang, Huaiyu Yang, Frank Noé, Zhenzhen Yan, Dexiang Jiang, Hangyu Zhang, Fengjiao Liu, Chenxin Xiao, Zhuo Zhou, Yimin Mou, Haijie Yu, Lijuan Ma, Chen Huang, Vincent Kam Wai Wong, Sookja Kim Chung, Bing Shen, Zhi-Hong Jiang, Erwin Neher, Wandi Zhu, Jin Zhang, Panpan Hou
https://doi.org/10.1038/s41422-025-01182-9
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ATP-dependent one-dimensional movement maintains immune homeostasis by suppressing spontaneous MDA5 filament assembly

Xiao-Peng Han, Ming Rao, Yu Chang, Jun-Yan Zhu, Jun Cheng, Yu-Ting Li, Wu Qiong, Si-Chao Ye, Qiurong Zhang, Shao-Qing Zhang, Ling-Ling Chen, Fajian Hou, Jin Zhong, Jiaquan Liu
https://doi.org/10.1038/s41422-025-01183-8
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LETTERS TO THE EDITOR

Constitutive arrestin recruitment by orphan GPR52 via an atypical binding mode

Xi Lin, Xiaohu Wei, Ning Pu, Ling Wang, Zhibin Zhang, Cuixia Li, Yang Yue, Junlin Liu, Qiwen Tan, Qianqian Sun, Fei Xu
https://doi.org/10.1038/s41422-025-01165-w
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Molecular basis of vitamin K-dependent protein γ-glutamyl carboxylation

Qihang Zhong, Dandan Chen, Jinkun Xu, Yao Li, Wanqiong Yuan, Yan Meng, Qi Wen, Qiwei Ye, Guopeng Wang, Kexin Pan, Chunli Song, Lin Tao, Jie Qiao, Jing Hang
https://doi.org/10.1038/s41422-025-01185-6
Full Text | PDF | Abstract | Open Access