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Table of Contents

Volume 36 Issue 6, Jun 2026

An atlas of 13 million AI-predicted protein structures across the insect tree of life sheds light on ‘dark’ proteins, with the discovery of structurally conserved cGAS-like receptors (cGLRs) widespread in insects and involved in antiviral defense in the yellow fever mosquito. See page 411–425 by Weiyin Wu et al. for details.

RESEARCH HIGHLIGHTS

Carnitine biosynthesis governs fuel switching

Kyounghee Min, Philipp E. Scherer
https://doi.org/10.1038/s41422-026-01229-5
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A lipid “glue” for STING oligomers

Zhiqi Sun, Veit Hornung
https://doi.org/10.1038/s41422-026-01243-7
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Borrowed mitochondria, spared neurons

Gwang-Bum Im, Juan M. Melero-Martin
https://doi.org/10.1038/s41422-026-01230-y
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Mapping brain cell-type-specific diversity of lysosomal proteins

Adriana E. Golding, Raffaella De Pace
https://doi.org/10.1038/s41422-026-01242-8
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Extrachromosomal DNA drives cancer evolution

Ilio Vitale, Alessandro D’Ambrosio, Lorenzo Galluzzi
https://doi.org/10.1038/s41422-026-01225-9
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ORIGINAL ARTICLES

Social status impacts T-cell responses through synapse strength in the prefrontal cortex

Hui Xiong, Daniel Amado-Ruiz, Tessa R. Lodder, Mireille Toebes, Ton N. Schumacher, Hailan Hu, Helmut W. Kessels
https://doi.org/10.1038/s41422-026-01235-7
Full Text | PDF | Abstract | Open Access


Structural genomics sheds light on protein functions and remote homologs across the insect tree of life

Weiyin Wu, Chunlai Cui, Yixiao Zhu, Jingxuan Chen, Qiancheng Zhuang, Yazhou Wang, Zicheng Liu, Han Gao, Guo-Zheng Ou, Chao Liu, Mei Tao, Yun Chen, Ronghui Pan, Guojie Zhang, Hua Cai, Jinghua Yang, Xue-xin Chen, Xiaofan Zhou, Sibao Wang, Xing-Xing Shen
https://doi.org/10.1038/s41422-026-01220-0
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Assembly and gating mechanism of native AMPA receptors from the cerebellum

Xiaojing Li, Renjie Li, Yiqing Wei, Jiexin Chen, Jiaojiao Zhao, Jun Zhao, Wei Wang, Na Li, Lili Wang, Tuo Hu, Yanli Dong, Yongping Zhu, Chao Wei, Long Li, Wei Zhang, Zhuo Huang, Yan Zhao
https://doi.org/10.1038/s41422-026-01234-8
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40 Hz light flickering alleviates chronic pain via adenosine signaling in the retina-amygdala pathway

Jiawang Chen, Tao Xu, Chenchen Zhang, Li Li, Yan He, Zhaoxia Sun, Jiasheng He, Zhimo Yao, Peng Cai, Yipeng Huang, Fenfen Ye, Wei Guo, Manli Jia, Jia Qu, Jiang-Fan Chen, Yi Zhang
https://doi.org/10.1038/s41422-026-01227-7
Full Text | PDF | Abstract | Open Access


LETTERS TO THE EDITOR

Population-scale multi-omics analysis reveals diverse phenotypic impacts of lncRNAs in rice

Ge Gao, Danjing Lou, Yunpeng Li, Chao Zhang, Baolin Kan, Hao Wen, Siyu Wen, Jun Shu, Wenlong Guo, Weihua Qiao, Qingwen Yang, Youlin Peng, Kenneth M. Olsen, Qian Qian, Xiaoming Zheng
https://doi.org/10.1038/s41422-026-01247-3
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CORRIGENDA

Author Correction: Isolation and proteomic analysis of the SYP61 compartment reveal its role in exocytic trafficking in Arabidopsis

Georgia Drakakaki, Wilhelmina van de Ven, Songqin Pa, Yansong Miao, Junqi Wang, Nana F Keinath, Brent Weatherly, Liwen Jiang, Karin Schumacher, Glenn Hicks, Natasha Raikhel
https://doi.org/10.1038/s41422-023-00865-5
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