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The ancient wisdom of “sacrificing a part to save the whole”, epitomized by the gecko’s tail detachment, finds its cellular parallel in lysosomal repair. When damaged, lysosomes employ TECPR1 to orchestrate the formation of repair tubules — a strategic excision that ensures organelle survival. This mechanism, essential for cellular integrity during energy stress, demonstrates how cells enact timeless survival strategies. See page 51–71 by Hanmo Chen et al. for details.
David C. Rubinsztein
https://doi.org/10.1038/s41422-025-01162-z
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Gina J. Fiala, Wolfgang W. Schamel
https://doi.org/10.1038/s41422-025-01168-7
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Chin Wei Brian Leung, Fumiko Esashi
https://doi.org/10.1038/s41422-025-01159-8
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Qibin Wu, Wanying Zhao, Zheng Qing Fu, Youxiong Que
https://doi.org/10.1038/s41422-025-01169-6
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Shohei Asami, Hiroshi Ohno
https://doi.org/10.1038/s41422-025-01166-9
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Qi Wang, Yu Sun, Terytty Yang Li, Johan Auwerx
https://doi.org/10.1038/s41422-025-01203-7
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Qiuling Zhao, Chenglong Li, Mengsi Zhang, Tingfang Gao, Zhidong Wang, Zhi Li, Yan Qin, Xinwen Xue, Mengyun Chen, Chengping Xu, Guozhi Zhang, Xiang Cui, Kangjian Zhang, Xiaowei Qi, Xiu-Wu Bian, Yi Yang
https://doi.org/10.1038/s41422-025-01205-5
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Hanmo Chen, Chaojun Zhang, Yuhui Fu, Linsen Li, Xiaoyu Qiao, Shen Zhang, Hanyan Luo, She Chen, Xiaoxia Liu, Qing Zhong
https://doi.org/10.1038/s41422-025-01193-6
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Wen-Hui Ma, Wen-Yi Li, Tao Chen, Linqian Jing, Yue-Hong Chen, Kejun Li, Zhuo-Luo Xu, Rong-Fang Shen, Yutong He, Tingyu Mou, Ting-Yue Luo, Xiangnan Sun, Zhao-Kun Wu, Li-Jing Wang, Hong-Juan Liu, Xiaozhong Qiu, Yi Gao, Xiaochun Bai, Wei Wang, Dalei Wu, Guoxin Li, Wei-Jie Zhou
https://doi.org/10.1038/s41422-025-01206-4
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