EDITORIAL

A special issue on cell signaling, disease, and stem cells

Dangsheng Li
Cell Research (2012) 22:1-2. doi:10.1038/cr.2012.7; published online 5 January 2012
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RESEARCH HIGHLIGHTS

Ingested plant miRNAs regulate gene expression in animals

Hervé Vaucheret and Yves Chupeau
Cell Research (2012) 22:3-5. doi:10.1038/cr.2011.164; published online 25 October 2011
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Investigating the bona fide differentiation capacity of human pluripotent stem cells

Jian-Chien Dominic Heng, Kyle M Loh and Huck-Hui Ng
Cell Research (2012) 22:6-8. doi:10.1038/cr.2011.142; published online 30 August 2011
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Axing Wnt signals

Felipe De Sousa E Melo and Jan Paul Medema
Cell Research (2012) 22:9-11. doi:10.1038/cr.2011.141; published online 30 August 2011
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Watching lymphatic vessels grow by making them glow

Steven T Proulx and Michael Detmar
Cell Research (2012) 22:12-13. doi:10.1038/cr.2011.191; published online 29 November 2011
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REVIEWS

Signal control through Raf: in sickness and in health

Jihan K Osborne, Elma Zaganjor and Melanie H Cobb
Cell Research (2012) 22:14-22. doi:10.1038/cr.2011.193; published online 6 December 2011
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Semaphorin signaling in angiogenesis, lymphangiogenesis and cancer

Atsuko Sakurai, Colleen Doci and J Silvio Gutkind
Cell Research (2012) 22:23-32. doi:10.1038/cr.2011.198; published online 13 December 2011
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Determinants of public T cell responses

Hanjie Li, Congting Ye, Guoli Ji and Jiahuai Han
Cell Research (2012) 22:33-42. doi:10.1038/cr.2012.1; published online 3 January 2012
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Autophagy: for better or for worse

Ellen Wirawan, Tom Vanden Berghe, Saskia Lippens, Patrizia Agostinis and Peter Vandenabeele
Cell Research (2012) 22:43-61. doi:10.1038/cr.2011.152; published online 13 September 2011
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Modeling sarcomagenesis using multipotent mesenchymal stem cells

Rene Rodriguez, Ruth Rubio and Pablo Menendez
Cell Research (2012) 22:62-77. doi:10.1038/cr.2011.157; published online 20 September 2011
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APP physiological and pathophysiological functions: insights from animal models

Qinxi Guo , Zilai Wang , Hongmei Li , Mary Wiese and Hui Zheng
10.1038/cr.2011.116; published online 19 July 2011
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Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms

Qian Qin, Young Xu, Tao He, Chunlin Qin and Jianming Xu
Cell Research (2012) 22:90-106. doi:10.1038/cr.2011.144; published online 30 August 2011
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ORIGINAL ARTICLES

Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA

Lin Zhang, Dongxia Hou, Xi Chen, Donghai Li, Lingyun Zhu, Yujing Zhang, Jing Li, Zhen Bian, Xiangying Liang, Xing Cai, Y
Cell Research (2012) 22:107-126. doi:10.1038/cr.2011.158; published online 20 September 2011
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Caspase cleavage of cytochrome c1 disrupts mitochondrial function and enhances cytochrome c release

Yushan Zhu, Min Li, Xiaohui Wang, Haijing Jin, Shusen Liu1, Jianxin Xu and Quan Chen
Cell Research (2012) 22:127-141. doi:10.1038/cr.2011.82; published online 17 May 2011
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Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature

>Huansheng Xu, B Alexander Yi, Hao Wu, Christoph Bock, Hongcang Gu, Kathy O Lui, Joo-Hye C Park, Ying Shao, Alyssa K Riley
Cell Research (2012) 22:142-154. doi:10.1038/cr.2011.171; published online 8 November 2011
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Oct4 links multiple epigenetic pathways to the pluripotency network

Junjun Ding, Huilei Xu, Francesco Faiola, Avi Ma'ayan and Jianlong Wang
Cell Research (2012) 22:155-167. doi:10.1038/cr.2011.179; published online 15 November 2011
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The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming

Athanasia D Panopoulos, Oscar Yanes, Sergio Ruiz, Yasuyuki S Kida1, Dinh Diep, Ralf Tautenhahn, Aída Herrerías, Erika M Batchelder, Nongluk Plon
Cell Research (2012) 22:168-177. doi:10.1038/cr.2011.177; published online 8 November 2011
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Defining the nature of human pluripotent stem cell progeny

Michaela Patterson, David N. Chan, Iris Ha, Dana Case, Yongyan Cui, Ben Van Handel, Hanna KA Mikkola and William E Lowry
Cell Research (2012) 22:178-193. doi:10.1038/cr.2011.133; published online 16 August 2011
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TGFβ inhibition enhances the generation of hematopoietic progenitors from human ES cell-derived hemogenic endothelial cells using a stepwise strategy

Chengyan Wang, Xuming Tang, Xiaomeng Sun, Zhenchuan Miao, Yaxin Lv, Yanlei Yang, Huidan Zhang, Pengbo Zhang, Yang Liu, Liying Du
¹Department of Cell Biology, The MOE Key Laboratory of Cell Proliferation and Differentiation, College of Life Sciences, Peking University, Beijing 100871, China
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Direct reprogramming of sertoli cells into multipotent neural stem cells by defined factors

Chao Sheng, Qinyuan Zheng, Jianyu Wu, Zhen Xu, Libin Wang, Wei Li, Haijiang Zhang, Xiao-Yang Zhao, Lei Liu, Ziwei Wang1,6
Multipotent neural stem/progenitor cells hold great promise for cell therapy. The reprogramming of fibroblasts to induced pluripotent stem cells as well as mature neurons suggests a possibility to convert a terminally differentiated somatic cell into a mu
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Ascorbic acid enhances the cardiac differentiation of induced pluripotent stem cells through promoting the proliferation of cardiac progenitor cells

Nan Cao, Zumei Liu, Zhongyan Chen, Jia Wang, Taotao Chen, Xiaoyang Zhao, Yu Ma, Lianju Qin, Jiuhong Kang, Bin Wei, Liu Wang3
Cell Research (2012) 22:219-236. doi:10.1038/cr.2011.195; published online 6 December 2011
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Small molecule-based disruption of the Axin/β-catenin protein complex regulates mesenchymal stem cell differentiation

Jungsug Gwak, Sun Gwan Hwang, Hyung-Soon Park, Sang Rak Choi, Sun-Hee Park, Hyunjoon Kim, Nam-Chul Ha, Sung Jin Bae, Jin-Kwan Han, Dong-
Cell Research (2012) 22:237-247. doi:10.1038/cr.2011.127; published online 9 August 2011
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Identification and expansion of cancer stem cells in tumor tissues and peripheral blood derived from gastric adenocarcinoma patients

Tie Chen, Kun Yang, Jianhua Yu, Wentong Meng, Dandan Yuan, Feng Bi, Fang Liu, Jie Liu, Bing Dai, Xinzu Chen, Fang Wang2
Cell Research (2012) 22:248-258. doi:10.1038/cr.2011.109; published online 5 July 2011
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The critical role of CD133⁺CD44^+/high tumor cells in hematogenous metastasis of liver cancers

Ying Hou, Qifei Zou, Ruiliang Ge, Feng Shen and Yizheng Wang
Cell Research (2012) 22:259-272. doi:10.1038/cr.2011.139; published online 23 August 2011
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