RESEARCH HIGHLIGHTS

V-cGAPs: attenuators of 3′3′-cGAMP signaling

Pu Gao and Dinshaw J Patel
10.1038/cr.2015.48
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Resolving sorting mechanisms into exosomes

Willem Stoorvogel
10.1038/cr.2015.39
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CD146: the unveiling of a pro-angiogenic netrin receptor

Brad St Croix
10.1038/cr.2015.42
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TREM2 enables amyloid β clearance by microglia

Serge Rivest
10.1038/cr.2015.37
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Nutrient stress revamps cancer cell metabolism

Jorge Moscat, Adam Richardson and Maria T Diaz-Meco
10.1038/cr.2015.38
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ORIGINAL ARTICLES

Identification and characterization of phosphodiesterases that specifically degrade 3′3′-cyclic GMP-AMP

Juyi Gao, Jianli Tao, Weili Liang, Meng Zhao, Xiaoxia Du, Shan Cui, Haifeng Duan, Biao Kan, Xiaodong Su and Zhengfan Jiang
10.1038/cr.2015.40
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Cryo-EM structure of SNAP-SNARE assembly in 20S particle

Qiang Zhou, Xuan Huang, Shan Sun, Xueming Li, Hong-Wei Wang and Sen-Fang Sui
10.1038/cr.2015.47
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ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer

Shunrong Ji, Yi Qin, Si Shi, Xiangyuan Liu, Hongli Hu, Hu Zhou, Jing Gao, Bo Zhang, Wenyan Xu, Jiang Liu, Dingkong Liang, Liang Liu, Chen Liu, Jiang Long, Haijun Zhou, Paul J Chiao, Jin Xu, Quanxing Ni, Daming Gao and Xianjun Yu
10.1038/cr.2015.30
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Three-dimensional human facial morphologies as robust aging markers

Weiyang Chen, Wei Qian, Gang Wu, Weizhong Chen, Bo Xian, Xingwei Chen, Yaqiang Cao, Christopher D Green, Fanghong Zhao, Kun Tang and Jing-Dong J Han
10.1038/cr.2015.36
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Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment

Pu Li, Jing-Xuan Shan, Xue-Hua Chen, Di Zhang, Li-Ping Su, Xiu-Ying Huang, Bei-Qin Yu, Qiao-Ming Zhi, Cheng-Long Li, Ya-Qing Wang, Sara Tomei, Qu Cai, Jun Ji, Jian-Fang Li, Lotfi Chouchane, Ying-Yan Yu, Fang-Zhen Sun, Zhi-Heng Xu, Bing-Ya Liu and Zheng-Gang Zhu
10.1038/cr.2015.51
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Structural basis for the neutralization of hepatitis E virus by a cross-genotype antibody

Ying Gu, Xuhua Tang, Xiao Zhang, Cuiling Song, Minghua Zheng, Kaihang Wang, Jun Zhang, Mun-Hon Ng, Choy-Leong Hew, Shaowei Li, Ningshao Xia and J. Sivaraman
10.1038/cr.2015.34
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Deficient plastidic fatty acid synthesis triggers cell death by modulating mitochondrial reactive oxygen species

Jian Wu, Yuefeng Sun, Yannan Zhao, Jian Zhang, Lilan Luo, Meng Li, Jinlong Wang, Hong Yu, Guifu Liu, Liusha Yang, Guosheng Xiong, Jian-Min Zhou, Jianru Zuo, Yonghong Wang and Jiayang Li
10.1038/cr.2015.46
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LETTERS TO THE EDITOR

Intron targeting-mediated and endogenous gene integrity-maintaining knockin in zebrafish using the CRISPR/Cas9 system

Jia Li, Bai-bing Zhang, Yong-gang Ren, Shan-ye Gu, Yuan-hang Xiang, Cheng Huang and Jiu-lin Du
10.1038/cr.2015.43
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Regulation of transcriptionally active genes via the catalytically inactive Cas9 in C. elegans and D. rerio

Lijiang Long, Hong Guo, Di Yao, Kai Xiong, Yongjun Li, Pengpeng Liu, Zuoyan Zhu and Dong Liu
10.1038/cr.2015.35
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Paternally contributed centrioles exhibit exceptional persistence in C. elegans embryos

Fernando R Balestra, Lukas von Tobel and Pierre Gönczy
10.1038/cr.2015.49
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CORRIGENDA

Generation of neural progenitor cells by chemical cocktails and hypoxia

Lin Cheng, Wenxiang Hu, Binlong Qiu, Jian Zhao, Yongchun Yu, Wuqiang Guan, Min Wang, Wuzhou Yang and Gang Pei
10.1038/cr.2015.55
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