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Table of Contents

Volume 31 Issue 12, Dec 2021

Treatment with mesenchymal stem cells (MSCs) can improve the outcomes of COVID-19 patients by restoring a harmonious homeostasis of the immune microenvironment disrupted by SARS-CoV-2 attack and promoting the immune system recovery. This process suggests a new interpretation to the story of “Moses divided the Red Sea” in the Exodus of the Bible: MSC therapy represents a promising new way in the treatment of COVID-19. See page 1244-1262 by Rongjia Zhu et al. for details.

EDITORIAL

Sanofi-Cell Research outstanding paper award of 2020

Cell Research Editorial Team
https://doi.org/10.1038/s41422-021-00593-8
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RESEARCH HIGHLIGHTS

Novel attempts launched toward universal Sarbecovirus vaccine

Haoyang Li, Erica Ollmann Saphire
https://doi.org/10.1038/s41422-021-00556-z
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Leveraging immunochemotherapy for treating pancreatic cancer

Anushka Dongre, Robert A. Weinberg
https://doi.org/10.1038/s41422-021-00574-x
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ORIGINAL ARTICLES

SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation

Gang Xu, Ying Li, Shengyuan Zhang, Haoran Peng, Yunyun Wang, Dekang Li, Taijie Jin, Zhuohao He, Yilun Tong, Chunting Qi, Guowei Wu, Kangyun Dong, Jizhou Gou, Yang Liu, Tongyang Xiao, Jing Qu, Liang Li, Liang Liu, Ping Zhao, Zheng Zhang, Junying Yuan
https://doi.org/10.1038/s41422-021-00578-7
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Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms

Rongjia Zhu, Tingdong Yan, Yingmei Feng, Yan Liu, Hongcui Cao, Gongxin Peng, Yanlei Yang, Zhen Xu, Jingqi Liu, Wei Hou, Xiaoyue Wang, Zhe Li, Luchan Deng, Shihua Wang, Jing Li, Qin Han, Hongling Li, Guangliang Shan, Yinghao Cao, Xingyan An, Jianshe Yan, Zhonghui Zhang, Huafei Li, Xuebin Qu, Jiaqi Zhu, Shumin Zhou, Jiao Wang, Fengchun Zhang, Jinming Gao, Ronghua Jin, Dayong Xu, Yan-Qing Ma, Tao Huang, Shuang Peng, Zhi Zheng, Ilia Stambler, Eric Gilson, Lee Wei Lim, Alexey Moskalev, Antonio Cano, Sasanka Chakrabarti, Brun Ulfhake, Huanxing Su, Haoying Xu, Sihuan Xu, Feng Wei, Holly M. Brown-Borg, Kyung-Jin Min, Georgina Ellison-Hughes, Calogero Caruso, Kunlin Jin, Robert Chunhua Zhao
https://doi.org/10.1038/s41422-021-00573-y
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Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition

Yuan Yuan, Guowen Jia, Chao Wu, Wei Wang, Lin Cheng, Qian Li, Ziyan Li, Kaidong Luo, Shengyong Yang, Wei Yan, Zhaoming Su, Zhenhua Shao
https://doi.org/10.1038/s41422-021-00566-x
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Zipper head mechanism of telomere synthesis by human telomerase

Futang Wan, Yongbo Ding, Yuebin Zhang, Zhenfang Wu, Shaobai Li, Lin Yang, Xiangyu Yan, Pengfei Lan, Guohui Li, Jian Wu, Ming Lei
https://doi.org/10.1038/s41422-021-00586-7
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Integrin αEβ7+ T cells direct intestinal stem cell fate decisions via adhesion signaling

Shiyang Chen, Yajuan Zheng, Xiaojuan Ran, Hui Du, Hua Feng, Lei Yang, Yating Wen, Changdong Lin, Shihui Wang, Mengwen Huang, Zhanjun Yan, Dianqing Wu, Hongyan Wang, Gaoxiang Ge, An Zeng, Yi Arial Zeng, Jianfeng Chen
https://doi.org/10.1038/s41422-021-00561-2
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LETTERS TO THE EDITOR

The ChinaMAP reference panel for the accurate genotype imputation in Chinese populations

Lin Li, Peide Huang, Xiaohui Sun, Siyu Wang, Min Xu, Sha Liu, Zhimin Feng, Qing Zhang, Xiaoji Wang, Xiaole Zheng, Mengyao Dai, Yufang Bi, Guang Ning, Yanan Cao, Weiqing Wang
https://doi.org/10.1038/s41422-021-00564-z
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Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric Gs

Lu Xu, Bo Chen, Hannes Schihada, Shane C. Wright, Ainoleena Turku, Yiran Wu, Gye-Won Han, Maria Kowalski-Jahn, Pawel Kozielewicz, Carl-Fredrik Bowin, Xianjun Zhang, Chao Li, Michel Bouvier, Gunnar Schulte, Fei Xu
https://doi.org/10.1038/s41422-021-00525-6
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Merging PROTAC and molecular glue for degrading BTK and GSPT1 proteins concurrently

Zimo Yang, Yonghui Sun, Zhihao Ni, Celi Yang, Yan Tong, Yujie Liu, Haitao Li, Yu Rao
https://doi.org/10.1038/s41422-021-00533-6
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CORRIGENDA

Author Corrections: Reconstruction of cell spatial organization from single-cell RNA sequencing data based on ligand-receptor mediated self-assembly

Xianwen Ren, Guojie Zhong, Qiming Zhang, Lei Zhang, Yujie Sun, Zemin Zhang
https://doi.org/10.1038/s41422-021-00550-5
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CORRIGENDUM

Author Correction: The mitochondrial genome encodes abundant small noncoding RNAs

Seungil Ro, Hsiu-Yen Ma, Chanjae Park, Nicole Ortogero, Rui Song, Grant W Hennig, Huili Zheng, Yung-Ming Lin, Loredana Moro, Jer-Tsong Hsieh, Wei Yan
https://doi.org/10.1038/s41422-021-00571-0
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