RESEARCH HIGHLIGHTS

Up or down: where comes Omicron?

Zezhong Liu, Lu Lu, Shibo Jiang
https://doi.org/10.1038/s41422-022-00675-1
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A SNIPpet of safety: a Goldilocks approach in CAR-T therapy

Mehdi Benzaoui, Naomi Taylor, Nirali N. Shah
https://doi.org/10.1038/s41422-022-00682-2
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A gut feeling: diet-sensing mesenchymal cells regulate intestinal stem cell function

Julia Messina-Pacheco, Alex Gregorieff
https://doi.org/10.1038/s41422-022-00658-2
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Cytoskeleton grows p62 condensates for autophagy

Nobuo N. Noda
https://doi.org/10.1038/s41422-022-00671-5
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ORIGINAL ARTICLES

Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.2 variant compared to BA.1 and their possible mouse origins

Youwei Xu, Canrong Wu, Xiaodan Cao, Chunyin Gu, Heng Liu, Mengting Jiang, Xiaoxi Wang, Qingning Yuan, Kai Wu, Jia Liu, Deyi Wang, Xianqing He, Xueping Wang, Su-Jun Deng, H. Eric Xu, Wanchao Yin
https://doi.org/10.1038/s41422-022-00672-4
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Nuclear RIPK1 promotes chromatin remodeling to mediate inflammatory response

Wanjin Li, Bing Shan, Chengyu Zou, Huibing Wang, Meng-Meng Zhang, Hong Zhu, Masanori Gomi Naito, Daichao Xu, Vica Jean Manuel, Lauren Mifflin, Zhaodong Hou, John Ravits, Junying Yuan
https://doi.org/10.1038/s41422-022-00673-3
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SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors

Xiaomin Wang, Ziqi Chen, Jun Xu, Shuai Tang, Nan An, Lei Jiang, Yixiang Zhang, Shaoying Zhang, Qingli Zhang, Shijie Chen, Xiaojing Lan, Ting Wang, Linhui Zhai, Siyuwei Cao, Siqi Guo, Yingluo Liu, Aiwei Bi, Yuehong Chen, Xiameng Gai, Yichen Duan, Ying Zheng, Yixian Fu, Yize Li, Liang Yuan, Linjiang Tong, Kun Mo, Mingcheng Wang, Shu-Hai Lin, Minjia Tan, Cheng Luo, Yi Chen, Jia Liu, Qiansen Zhang, Leping Li, Min Huang
https://doi.org/10.1038/s41422-022-00650-w
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Myosin 1D and the branched actin network control the condensation of p62 bodies

Xuezhao Feng, Wanqing Du, Mingrui Ding, Wenkang Zhao, Xirenayi Xirefu, Meisheng Ma, Yuhui Zhuang, Xiaoyu Fu, Jiangfeng Shen, Jinpei Zhang, Xiuying Lei, Daxiao Sun, Qing Xi, Yiliyasi Aisa, Qian Chen, Ying Li, Wenjuan Wang, Shanjin Huang, Li Yu, Pilong Li, Na Mi
https://doi.org/10.1038/s41422-022-00662-6
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Lepr⁺ mesenchymal cells sense diet to modulate intestinal stem/progenitor cells via Leptin–Igf1 axis

Min Deng, Christian F. Guerrero-Juarez, Xiaole Sheng, Jiuzhi Xu, Xi Wu, Kai Yao, Mengzhen Li, Xu Yang, Guilin Li, Jintao Xiao, Xiaowei Liu, Kaichun Wu, Fazheng Ren, Qing Nie, Maksim V. Plikus, Zhengquan Yu, Cong Lv
https://doi.org/10.1038/s41422-022-00643-9
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LETTERS TO THE EDITOR

The structure of erastin-bound xCT–4F2hc complex reveals molecular mechanisms underlying erastin-induced ferroptosis

Renhong Yan, Enjun Xie, Yaning Li, Jin Li, Yuanyuan Zhang, Ximin Chi, Xueping Hu, Lei Xu, Tingjun Hou, Brent R. Stockwell, Junxia Min, Qiang Zhou, Fudi Wang
https://doi.org/10.1038/s41422-022-00642-w
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Selection and structural bases of potent broadly neutralizing antibodies from 3-dose vaccinees that are highly effective against diverse SARS-CoV-2 variants, including Omicron sublineages

Lei Wang, Wangjun Fu, Linlin Bao, Zijing Jia, Yuxia Zhang, Yunjiao Zhou, Wei Wu, Jianbo Wu, Qianqian Zhang, Yidan Gao, Kang Wang, Qiao Wang, Chuan Qin, Xiangxi Wang
https://doi.org/10.1038/s41422-022-00677-z
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Structural basis of the activation of metabotropic glutamate receptor 3

Wei Fang, Fan Yang, Chanjuan Xu, Shenglong Ling, Li Lin, Yingxin Zhou, Wenjing Sun, Xiaomei Wang, Peng Liu, Philippe Rondard, Pan Shi, Jean-Philippe Pin, Changlin Tian, Jianfeng Liu
https://doi.org/10.1038/s41422-022-00623-z
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Treatment of autosomal recessive hearing loss via in vivo CRISPR/Cas9-mediated optimized homology-directed repair in mice

Xi Gu, Xinde Hu, Daqi Wang, Zhijiao Xu, Fang Wang, Di Li, Geng-lin Li, Hui Yang, Huawei Li, Erwei Zuo, Yilai Shu
https://doi.org/10.1038/s41422-022-00624-y
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CORRIGENDA

Author Correction: Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms

Zhenlin Yang, Huanhuan Liang, Qian Zhou, Ying Li, Haiwei Chen, Wen Ye, Danying Chen, Joy Fleming, Hongbing Shu, Yingfang Liu
https://doi.org/10.1038/s41422-022-00660-8
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