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Volume 36 Issue 2, Feb 2026

The Ancient Wall (bone) is safeguarded by a mysterious legion, with grey workers (Postn-lineage cells) maintaining its structure and red soldiers (Angptl7-lineage cells) standing alert. The Taotie (trauma) emerges, bringing devastation (bone fracture). As the mountains shake and beacon smoke (injury signals) darkens the sky, the soldiers are mobilized in a desperate struggle to repair the breach and repel the primordial terror. See page 121–136 by Bo Jiang et al. for details.

RESEARCH HIGHLIGHTS

Fibrous-layer periosteal stem cells sensing injury-induced inflammation

Noriaki Ono
https://doi.org/10.1038/s41422-025-01210-8
Full Text | PDF | Abstract


Gz and β-arrestin 1 signaling in the μ-opioid receptor

Zhi Cheng, Bryan L. Roth
https://doi.org/10.1038/s41422-025-01214-4
Full Text | PDF | Abstract


An anti-inflammatory autophagic target in chronic diseases

Prithvi Reddy Akepati, Vojo Deretic
https://doi.org/10.1038/s41422-025-01176-7
Full Text | PDF | Abstract


White matter interactome in vascular dementia

Stefan Wendt, Brian A. MacVicar
https://doi.org/10.1038/s41422-025-01175-8
Full Text | PDF | Abstract


REVIEW ARTICLE

Gut dysbiosis in oncology: a risk factor for immunoresistance

Andrew Allan Almonte, Simon Thomas, Valerio Iebba, Guido Kroemer, Lisa Derosa, Laurence Zitvogel
https://doi.org/10.1038/s41422-025-01212-6
Full Text | PDF | Abstract | Open Access


ORIGINAL ARTICLES

Fibrous-layer resident Angptl7+ periosteal stem cells sense injury inflammation to orchestrate fracture repair

Bo Jiang, Wenhui Xing, Xiaocui Xu, Shuqin Chen, Heng Feng, Rui Shao, Jiatong Sun, Yazhuo Zhang, Zaiqi Xie, Wenxiang Wang, Xubin Yin, Yi Wang, Miaomiao Wang, Ling Li, Zhong Zhang, Bo Gao, Jinlong Suo, Xuye Hu, Lijun Wang, Jun Sun, Bin Zho, Bo O. Zhou, Matthew B. Greenblatt, Rongrong Le, Weiguo Zou
https://doi.org/10.1038/s41422-025-01202-8
Full Text | PDF | Abstract | Open Access


Lactate-activated GPR81/FARP1 signaling drives insulin-independent glucose uptake and metabolic control

Yaxin Niu, Shengmin Hu, Yanfeng Zhang, Jinbao Yang, Jiarui Zhang, Ruiping He, Li Chen, Lin Xu, Hongfang Zhao, Bing Gan, Ruobing Ren, Ruth J. F. Loos, Haobin Ye, Xingrong Du, Tongjin Zhao, Peng Li, Antonio Vidal-Puig, Linzhang Huang
https://doi.org/10.1038/s41422-025-01207-3
Full Text | PDF | Abstract


The AHCY–adenosine complex rewires mRNA methylation to enhance fatty acid biosynthesis and tumorigenesis

Kun Liao, Fen Cao, Chen Wei, Zheng-Yu Qian, Hong-Rong Hu, Wen-Feng Pan, Zi-Qing Feng, Sen-mao Lian, Zi-Xuan Xiao, Hui Sheng, Hai-Yu Mo, Yi-Xuan Zhao, Qi-Nian Wu, Zhao-Lei Zeng, Bo Li, Rui-Hua Xu, Huai-Qiang Ju
https://doi.org/10.1038/s41422-025-01213-5
Full Text | PDF | Abstract | Open Access
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