RESEARCH HIGHLIGHTS

Drosha and Dicer: Slicers cut from the same cloth

Sisi Li and Dinshaw J Patel
10.1038/cr.2016.19
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Duchenne muscular dystrophy: CRISPR/Cas9 treatment

Jerry R Mendell and Louise R Rodino-Klapac
10.1038/cr.2016.28
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Seeing is believing: Wnt3 localization in the gut epithelium

Alex Gregorieff and Jeffrey L Wrana
10.1038/cr.2016.41
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ORIGINAL ARTICLES

MLKL forms cation channels

Bingqing Xia, Sui Fang, Xueqin Chen, Hong Hu, Peiyuan Chen, Huayi Wang and Zhaobing Gao
10.1038/cr.2016.26
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A positive role for polycomb in transcriptional regulation via H4K20me1

Xiangdong Lv, Zhijun Han, Hao Chen, Bo Yang, Xiaofeng Yang, Yuanxin Xia, Chenyu Pan, Lin Fu, Shuo Zhang, Hui Han, Min Wu, Zhaocai Zhou, Lei Zhang, Lin Li, Gang Wei and Yun Zhao
10.1038/cr.2016.33
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Crystal structure of PXY-TDIF complex reveals a conserved recognition mechanism among CLE peptide-receptor pairs

Heqiao Zhang, Xiaoya Lin, Zhifu Han, Li-Jia Qu and Jijie Chai
10.1038/cr.2016.45
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Positive selection rather than relaxation of functional constraint drives the evolution of vision during chicken domestication

Ming-Shan Wang, Rong-wei Zhang, Ling-Yan Su, Yan Li, Min-Sheng Peng, He-Qun Liu, Lin Zeng, David M Irwin, Jiu-Lin Du, Yong-Gang Yao, Dong-Dong Wu and Ya-Ping Zhang
10.1038/cr.2016.44
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Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor

Katie Leach, Karen J Gregory, Irina Kufareva, Elham Khajehali, Anna E Cook, Ruben Abagyan, Arthur D Conigrave, Patrick M Sexton and Arthur Christopoulos
10.1038/cr.2016.36
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Numb regulates vesicular docking for homotypic fusion of early endosomes via membrane recruitment of Mon1b

Ximing Shao, Yi Liu, Qian Yu, Zhihao Ding, Wenyu Qian, Lei Zhang, Jianchao Zhang, Nan Jiang, Linfei Gui, Zhiheng Xu, Yang Hong, Yifan Ma, Yanjie Wei, Xiaoqing Liu, Changan Jiang, Minyan Zhu, Hongchang Li and Huashun Li
10.1038/cr.2016.34
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TRIM9 short isoform preferentially promotes DNA and RNA virus-induced production of type I interferon by recruiting GSK3β to TBK1

Yunfei Qin, Qingxiang Liu, Shuo Tian, Weihong Xie, Jun Cui and Rong-Fu Wang
10.1038/cr.2016.27
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LETTERS TO THE EDITOR

YEATS2 is a selective histone crotonylation reader

Dan Zhao, Haipeng Guan, Shuai Zhao, Wenyi Mi, Hong Wen, Yuanyuan Li, Yingming Zhao, C David Allis, Xiaobing Shi and Haitao Li
10.1038/cr.2016.49
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One-step homozygosity in precise gene editing by an improved CRISPR/Cas9 system

Pei Zhao, Zhe Zhang, Xiaoying Lv, Xiang Zhao, Yuji Suehiro, Yinan Jiang, Xinquan Wang, Shohei Mitani, Haipeng Gong and Ding Xue
10.1038/cr.2016.46
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