RESEARCH HIGHLIGHTS

Mitochondrial fusion fuels T cell memory

Alessio Lanna and Michael L Dustin
10.1038/cr.2016.94
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Restoring stem cells — all you need is NAD⁺

Lindsay E Wu and David A Sinclair
10.1038/cr.2016.80
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Closing the gap: astrocytes and brain metastasis

Gino B Ferraro, David P Kodack, Vasileios Askoxylakis and Rakesh K Jain
10.1038/cr.2016.96
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Dissecting the bone marrow hematopoietic stem cell niches

Meng Zhao and Linheng Li
10.1038/cr.2016.71
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ORIGINAL ARTICLES

Structural insights into Ca2+-activated long-range allosteric channel gating of RyR1

Risheng Wei, Xue Wang, Yan Zhang, Saptarshi Mukherjee, Lei Zhang, Qiang Chen, Xinrui Huang, Shan Jing, Congcong Liu, Shuang Li, Guangyu Wang, Yaofang Xu, Sujie Zhu, Alan J Williams, Fei Sun and Chang-Cheng Yin
10.1038/cr.2016.99
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The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening

Xiao-Chen Bai, Zhen Yan, Jianping Wu, Zhangqiang Li and Nieng Yan
10.1038/cr.2016.89
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Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis

Xin Chen, Wan-ting He, Lichen Hu, Jingxian Li, Yuan Fang, Xin Wang, Xiaozheng Xu, Zhuo Wang, Kai Huang1 and Jiahuai Han
10.1038/cr.2016.100
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Ferroptosis is an autophagic cell death process

Minghui Gao, Prashant Monian, Qiuhui Pan, Wei Zhang, Jenny Xiang and Xuejun Jiang
10.1038/cr.2016.95
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Cortical neurons gradually attain a post-mitotic state

Froylan Calderon de Anda, Ram Madabhushi, Damien Rei, Jia Meng, Johannes Gräff, Omer Durak, Konstantinos Meletis, Melanie Richter, Birgit Schwanke, Alison Mungenast and Li-Huei Tsai
10.1038/cr.2016.76
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TALEN-based generation of a cynomolgus monkey disease model for human microcephaly

Qiong Ke, Weiqiang Li, Xingqiang Lai, Hong Chen, Lihua Huang, Zhuang Kang, Kai Li, Jie Ren, Xiaofeng Lin, Haiqing Zheng, Weijun Huang, Yunhan Ma, Dongdong Xu, Zheng Chen, Xinming Song, Xinyi Lin1, Min Zhuang1, Tao Wang, Fengfeng Zhuang, Jianzhong Xi, Frank Fuxiang Mao, Huimin Xia, Bruce T Lahn1, Qi Zhou1, Shihua Yang and Andy Peng Xiang
10.1038/cr.2016.93
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LETTERS TO THE EDITOR

Structural basis of prokaryotic NAD-RNA decapping by NudC

Delin Zhang, Yexing Liu, Qiang Wang, Zeyuan Guan, Jing Wang, Jian Liu, Tingting Zou and Ping Yin
10.1038/cr.2016.98
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A genome-wide loss-of-function screening method for minimizing false-negatives caused by functional redundancy

Li Mao, Chenglin Liu, Zhen Wang, Xiaofeng Niu, Liang Xue, Zhilei Zhou, Zhenying Cai, Meng Yu, Yixue Li, Dianqing Wu and Lin Li
10.1038/cr.2016.97
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