RESEARCH HIGHLIGHTS

Anti-CTLA-4 immunotherapy: uncoupling toxicity and efficacy

Jonathan Pol and Guido Kroemer
10.1038/s41422-018-0031-9
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Heart muscle regeneration: the wonder of a Cardio-Cocktail

Matthew C Hill and James F Martin
10.1038/s41422-018-0035-5
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m6A deposition: a boost from TGFβ

Lior Lasman and Jacob H. Hanna
doi:10.1038/s41422-018-0037-3
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REVIEWS

RNA N6-methyladenosine modification in cancers: current status and perspectives

Xiaolan Deng Rui Su Hengyou Weng Huilin Huang, Zejuan Li and Jianjun Chen
doi:10.1038/s41422-018-0034-6
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ORIGINAL ARTICLES

Cryo-EM structure of human mTOR complex 2

Xizi Chen , Mengjie Liu , Yuan Tian , Jiabei Li , Yilun Qi , Dan Zhao , Zihan Wu , Min Huang ,Catherine C. L. Wong , Hong-Wei Wang , Jiawei Wang , Huirong Yang and Yanhui Xu
10.1038/s41422-018-0029-3
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Ligand-triggered de-repression of Arabidopsis heterotrimeric G proteins coupled to immune receptor kinases

Xiangxiu Liang , Miaomiao Ma , Zhaoyang Zhou , Jinlong Wang , Xinru Yang , Shaofei Rao , Guozhi Bi , Lin Li , Xiaojuan Zhang,Jijie Chai , She Chen and Jian-Min Zhou
10.1038/s41422-018-0027-5
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Anti-mitotic chemotherapeutics promote apoptosis through TL1A-activated death receptor 3 in cancer cells

Chen Qi , Xin Wang , Zhirong Shen She Chen , Hong Yu , Noelle Williams and Gelin Wang
10.1038/s41422-018-0018-6
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An NF90/NF110-mediated feedback amplification loop regulates dicer expression and controls ovarian carcinoma progression

Jérôme Barbier, Xin Chen, Gabriel Sanchez , Muyan Cai , Marion Helsmoortel , Takuma Higuchi, Pierre Giraud, Xavier Contreras ,Gangjun Yuan , Zihao Feng, Rima Nait-Saidi , Olivier Deas , Lisa Bluy , Jean-Gabriel Judde, Sylvie Rouquier, William Ritchie6,Shuji Sakamoto , Dan Xie and Rosemary Kiernan
doi:10.1038/s41422-018-0016-8
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KRAB-type zinc-finger proteins PITA and PISA specifically regulate p53-dependent glycolysis and mitochondrial respiration

Shan Wang , Zhiqiang Peng , Siying Wang , Lihua Yang, Yuhan Chen , Xue Kong , Shanshan Song , Pei Pei , Chunyan Tian ,Hui Yan, Peipei Ding , Weiguo Hu, Cui Hua Liu , Xin Zhang , Fuchu He and Lingqiang Zhang
10.1038/s41422-018-0008-8
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LETTERS TO THE EDITOR

Silencing of developmental genes by H3K27me3 and DNA methylation reflects the discrepant plasticity of embryonic and extraembryonic lineages

Xianfa Yang , Boqiang Hu , Yu Hou , Yunbo Qiao ,Ran Wang , Yingying Chen , Yun Qian , Su Feng, Jun Chen ,Chang Liu , Guangdun Peng , Fuchou Tang and Naihe Jing
10.1038/s41422-018-0010-1
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Circulating tumor DNA 5-hydroxymethylcytosine as a novel diagnostic biomarker for esophageal cancer

Xin Tian , Baofa Sun, Chuanyuan Chen , Chunchun Gao ,Ji Zhang , Xingyu Lu , Linchen Wang , Xiangnan Li ,Yurong Xing, Ruijuan Liu , Xiao Han , Zheng Qi ,Xiaojian Zhang , Chuan He , Dali Han ,Yun-Gui Yang and Quancheng Kan
10.1038/s41422-018-0014-x
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Pan-cancer analysis of somatic mutations across 21 neuroendocrine tumor types

Yanan Cao , Weiwei Zhou, Lin Li, Jiaqian Wang , Zhibo Gao,Yiran Jiang, Xiuli Jiang , Aijing Shan, Matthew H. Bailey ,Kuan-lin Huang , Sam Q. Sun , Michael D. McLellan ,Beifang Niu, Weiqing Wang , Li Ding and Guang Ning
10.1038/s41422-018-0019-5
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