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Table of Contents

Volume 28 Issue 4, Apr 2018

Malate carrying the reducing equivalents is transported from chloroplast to cytosol (in plant) and then to mitochondrion (in plant and animal), which in turn provides electrons for mitochondrial ETC to regulate ROS generation and programmed cell death.

See page 448–461 by Yannan Zhao et al. for details.

The cover is artistically modified by Chuang Zhao (PNSO Beijing) based on the image provided by the authors.

RESEARCH HIGHLIGHTS

Ubiquitin-induced phase separation of p62/SQSTM1

Lina Herhaus and Ivan Dikic
doi:10.1038/s41422-018-0030-x
Full Text | PDF | Abstract


Tamoxifen and ERα36: Fertilizing the seeds of breast cancer metastasis

Monika L. Burness and Max S. Wicha
10.1038/s41422-018-0028-4
Full Text | PDF | Abstract


SETD2 — linking stem cell survival and transformation

Mrinal M. Patnaik and Omar Abdel-Wahab
10.1038/s41422-018-0025-7
Full Text | PDF | Abstract


REVIEWS

Modifications and functional genomics of human transfer RNA

Tao Pan
10.1038/s41422-018-0013-y
Full Text | PDF | Abstract | Open Access


ORIGINAL ARTICLES

Polyubiquitin chain-induced p62 phase separation drives autophagic cargo segregation

Daxiao Sun , Rongbo Wu , Jingxiang Zheng , Pilong Li and Li Yu
10.1038/s41422-018-0017-7
Full Text | PDF | Abstract | Open Access


A reappraisal of CTLA-4 checkpoint blockade in cancer immunotherapy

Xuexiang Du , Fei Tang , Mingyue Liu , Juanjuan Su, Yan Zhang , Wei Wu , Martin Devenport , Christopher A Lazarski, Peng Zhang ,Xu Wang , Peiying Ye , Changyu Wang, Eugene Hwang, Tinghui Zhu , Ting Xu, Pan Zheng and Yang Liu
10.1038/s41422-018-0011-0
Full Text | PDF | Abstract | Open Access


Uncoupling therapeutic from immunotherapy-related adverse effects for safer and effective anti-CTLA-4 antibodies in CTLA4 humanized mice

Xuexiang Du , Mingyue Liu , Juanjuan Su, Peng Zhang , Fei Tang , Peiying Ye , Martin Devenport , Xu Wang , Yan Zhang , Yang Liu and Pan Zheng
10.1038/s41422-018-0012-z
Full Text | PDF | Abstract | Open Access


Malate transported from chloroplast to mitochondrion triggers production of ROS and PCD in Arabidopsis thaliana

Yannan Zhao, Lilan Luo , Jiesi Xu, Peiyong Xin, Hongyan Guo , Jian Wu , Lin Bai , Guodong Wang, Jinfang Chu ,Jianru Zuo , Hong Yu , Xun Huang and Jiayang Li,
10.1038/s41422-018-0024-8
Full Text | PDF | Abstract | Open Access


Poly(ADP-ribose) mediates asymmetric division of mouse oocyte

Bingteng Xie , Lu Zhang , Huiling Zhao , Qingyun Bai , Yong Fan , Xiaohui Zhu , Yang Yu , Rong Li , Xin Liang , Qing-Yuan Sun , Mo Li and Jie Qiao
10.1038/s41422-018-0009-7
Full Text | PDF | Abstract


Setd2 deficiency impairs hematopoietic stem cell self-renewal and causes malignant transformation

Yuan-Liang Zhang , Jie-Wen Sun , Yin-Yin Xie , Yan Zhou , Ping Liu , Jia-Chun Song, Chun-Hui Xu, Lan Wang, Dan Liu , Ai-Ning Xu ,Zhu Chen , Sai-Juan Chen , Xiao-Jian Sun and Qiu-Hua Huang
10.1038/s41422-018-0015-9
Full Text | PDF | Abstract


LETTERS TO THE EDITOR

CRISPR-Cas12a has both cis- and trans-cleavage activities on single-stranded DNA

Shi-Yuan Li, Qiu-Xiang Cheng , Jia-Kun Liu, Xiao-Qun Nie ,Guo-Ping Zhao and Jin Wang
10.1038/s41422-018-0022-x
Full Text | PDF | Abstract


Molecular basis for histidine N1 position-specific methylation by CARNMT1

Ruili Cao , Xingrun Zhang , Xiaohui Liu, Yuanyuan Li and Haitao Li
10.1038/s41422-018-0003-0
Full Text | PDF | Abstract


Structural insight into the Zika virus capsid encapsulating the viral genome

Ting Li , Qi Zhao , Xiaoyun Yang , Cheng Chen , Kailin Yang ,Chen Wu , Tianqing Zhang , Yinkai Duan , Xiaoyu Xue, Kaixia Mi ,Xiaoyun Ji , Zefang Wang and Haitao Yang
10.1038/s41422-018-0007-9
Full Text | PDF | Abstract