Cell Research

Volume 31 Issue 1, Jan 2021

Ca2+-induced (fallen leaves) and phosphatase-checked (shrimps) shuttling of CaMKII (lotuses) enlarges postsynaptic density assembly (larger cluster of fish) and induces structural long-term potentiation.

RESEARCH HIGHLIGHTS

SARS-CoV-2-induced lung pathology: AHR as a candidate therapeutic target

Federico Giovannoni, Francisco J. Quintana
https://doi.org/10.1038/s41422-020-00447-9
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Water quality check: macrophages setting the standards

Camille Blériot, Zhaoyuan Liu, Florent Ginhoux
https://doi.org/10.1038/s41422-020-00429-x
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REVIEW ARTICLE

Calreticulin and cancer

Jitka Fucikova, Radek Spisek, Guido Kroemer, Lorenzo Galluzz
https://doi.org/10.1038/s41422-020-0383-9
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ORIGINAL ARTICLES

Dalbavancin binds ACE2 to block its interaction with SARS-CoV-2 spike protein and is effective in inhibiting SARS-CoV-2 infection in animal models

Gan Wang, Meng-Li Yang, Zi-Lei Duan, Feng-Liang Liu, Lin Jin, Cheng-Bo Long, Min Zhang, Xiao-Peng Tang, Ling Xu, Ying-Chang Li, Peter Muiruri Kamau, Lian Yang, Hong-Qi Liu, Jing-Wen Xu, Jie-Kai Chen, Yong-Tang Zheng, Xiao-Zhong Peng, Ren Lai
https://doi.org/10.1038/s41422-020-00450-0
Full Text | PDF | Abstract | Open Access

Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection

Hangping Yao, Yao Sun, Yong-Qiang Deng, Nan Wang, Yongcong Tan, Na-Na Zhang, Xiao-Feng Li, Chao Kong, Yan-Peng Xu, Qi Chen, Tian-Shu Cao, Hui Zhao, Xintian Yan, Lei Cao, Zhe Lv, Dandan Zhu, Rui Feng, Nanping Wu, Wenhai Zhang, Yuhao Hu, Keda Chen, Rong-Rong Zhang, Qingyu Lv, Shihui Sun, Yunhua Zhou, Run Yan, Guan Yang, Xinglu Sun, Chanjuan Liu, Xiangyun Lu, Linfang Cheng, Hongying Qiu, Xing-Yao Huang, Tianhao Weng, Danrong Shi, Weidong Jiang, Junbin Shao, Lei Wang, Jie Zhang, Tao Jiang, Guojun Lang, Cheng-Feng Qin, Lanjuan Li, Xiangxi Wang
https://doi.org/10.1038/s41422-020-00444-y
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CaMKIIα-driven, phosphatase-checked postsynaptic plasticity via phase separation

Qixu Cai, Menglong Zeng, Xiandeng Wu, Haowei Wu, Yumeng Zhan, Ruijun Tian, Mingjie Zhang
https://doi.org/10.1038/s41422-020-00439-9
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Molecular basis for ligand activation of the human KCNQ2 channel

Xiaoxiao Li, Qiansen Zhang, Peipei Guo, Jie Fu, Lianghe Mei, Dashuai Lv, Jiangqin Wang, Dongwu Lai, Sheng Ye, Huaiyu Yang, Jiangtao Guo
https://doi.org/10.1038/s41422-020-00410-8
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A novel selective autophagy receptor, CCDC50, delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection

Panpan Hou, Kongxiang Yang, Penghui Jia, Lan Liu, Yuxin Lin, Zibo Li, Jun Li, Shuliang Chen, Shuting Guo, Ji’An Pan, Junyu Wu, Hong Peng, Weijie Zeng, Chunmei Li, Yingfang Liu, Deyin Guo
https://doi.org/10.1038/s41422-020-0362-1
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Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle

Jing Liu, Yunhua Peng, Le Shi, Lixin Wan, Hiroyuki Inuzuka, Jiangang Lon, Jianping Guo, Jinfang Zhang, Min Yuan, Shuangxi Zhang, Xun Wang, Jing Gao, Xiangpeng Dai, Shozo Furumoto, Lijun Jia, Pier Paolo Pandolf, John M. Asara, William G. Kaelin Jr, Jiankang Liu, Wenyi Wei
https://doi.org/10.1038/s41422-020-0372-z
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LETTERS TO THE EDITOR

N6-methyladenine is incorporated into mammalian genome by DNA polymerase

Xiaoling Liu, Weiyi Lai, Yao Li, Shaokun Chen, Baodong Liu, Ning Zhang, Jiezhen Mo, Cong Lyu, Jing Zheng, Ya-Rui Du, Guibin Jiang, Guo-Liang Xu, Hailin Wang
https://doi.org/10.1038/s41422-020-0317-6
Full Text | PDF | Abstract | Open Access

Engineered trimeric ACE2 binds viral spike protein and locks it in “Three-up” conformation to potently inhibit SARS-CoV-2 infection

Liang Guo, Wenwen Bi, Xinling Wang, Wei Xu, Renhong Yan, Yuanyuan Zhang, Kai Zhao, Yaning Li, Mingfeng Zhang, Xia Cai, Shibo Jiang, Youhua Xie, Qiang Zhou, Lu Lu, Bobo Dang
https://doi.org/10.1038/s41422-020-00438-w
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Structure-based development of human antibody cocktails against SARS-CoV-2

Nan Wang, Yao Sun, Rui Feng, Yuxi Wang, Yan Guo, Li Zhang, Yong-Qiang Deng, Lei Wang, Zhen Cui, Lei Cao, Yan-Jun Zhang, Weimin Li, Feng-Cai Zhu, Cheng-Feng Qin, Xiangxi Wang
https://doi.org/10.1038/s41422-020-00446-w
Full Text | PDF | Abstract | Open Access