RESEARCH HIGHLIGHTS

A new molecular target for antidepressants

Sarah Ateaque, Yves-Alain Barde
https://doi.org/10.1038/s41422-021-00500-1
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Double insult: flu bug enhances SARS-CoV-2 infectivity

Shan Su, Zezhong Liu, Shibo Jiang
https://doi.org/10.1038/s41422-021-00498-6
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Developments in pluripotency: a new formative state

Stefan H. A. Hoogland, Hendrik Marks
https://doi.org/10.1038/s41422-021-00494-w
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ORIGINAL ARTICLES

Predicting dynamic cellular protein–RNA interactions by deep learning using in vivo RNA structures

Lei Sun, Kui Xu, Wenze Huang, Yucheng T. Yang, Pan Li, Lei Tang, Tuanlin Xiong, Qiangfeng Cliff Zhang
https://doi.org/10.1038/s41422-021-00476-y
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Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies

Renhong Yan, Ruoke Wang, Bin Ju, Jinfang Yu, Yuanyuan Zhang, Nan Liu, Jia Wang, Qi Zhang, Peng Chen, Bing Zhou, Yaning Li, Yaping Shen, Shuyuan Zhang, Long Tian, Yingying Guo, Lu Xia, Xinyue Zhong, Lin Cheng, Xiangyang Ge, Juanjuan Zhao, Hong-Wei Wang, Xinquan Wang, Zheng Zhang, Linqi Zhang, Qiang Zhou
https://doi.org/10.1038/s41422-021-00487-9
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Formative pluripotent stem cells show features of epiblast cells poised for gastrulation

Xiaoxiao Wang, Yunlong Xiang, Yang Yu, Ran Wang, Yu Zhang, Qianhua Xu, Hao Sun, Zhen-Ao Zhao, Xiangxiang Jiang, Xiaoqing Wang, Xukun Lu, Dandan Qin, Yujun Quan, Jiaqi Zhang, Ng Shyh-Chang, Hongmei Wang, Naihe Jing, Wei Xie, Lei Li
https://doi.org/10.1038/s41422-021-00477-x
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Mispair-bound human MutS–MutL complex triggers DNA incisions and activates mismatch repair

Janice Ortega, Grace Sanghee Lee, Liya Gu, Wei Yang, Guo-Min Li
https://doi.org/10.1038/s41422-021-00468-y
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Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing

Luca Mazzurana, Paulo Czarnewski, Viktor Jonsson, Leif Wigge, Markus Ringnér, Teresa C. Williams, Avinash Ravindran, Åsa K. Björklund, Jesper Säfholm, Gunnar Nilsson, Sven-Erik Dahlén, Ann-Charlotte Orre, Mamdoh Al-Ameri, Charlotte Höög, Charlotte Hedin, Sylwester Szczegielniak, Sven Almer, Jenny Mjösberg
https://doi.org/10.1038/s41422-020-00445-x
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Binding pathway determines norepinephrine selectivity for the human β1AR over β2AR

Xinyu Xu, Jonas Kaindl, Mary J. Clark, Harald Hübner, Kunio Hirata, Roger K. Sunahara, Peter Gmeiner, Brian K. Kobilka, Xiangyu Liu
https://doi.org/10.1038/s41422-020-00424-2
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A novel satiety sensor detects circulating glucose and suppresses food consumption via insulin-producing cells in Drosophila

Wei Qi, Gaohang Wang, Liming Wang
https://doi.org/10.1038/s41422-020-00449-7
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LETTERS TO THE EDITOR

Genome-scale profiling of circulating cell-free DNA signatures for early detection of hepatocellular carcinoma in cirrhotic patients

Lei Chen, Ghassan K. Abou-Alfa, Bo Zheng, Jing-Feng Liu, Jian Bai, Lu-Tao Du, Yun-Song Qian, Rong Fan, Xiao-Long Liu, Lin Wu, Jin-Lin Hou, Hong-Yang Wang, The PreCar Team
https://doi.org/10.1038/s41422-020-00457-7
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Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor

Youwen Zhuang, Brian Krumm, Huibing Zhang, X. Edward Zhou, Yue Wang, Xi-Ping Huang, Yongfeng Liu, Xi Cheng, Yi Jiang, Hualiang Jiang, Cheng Zhang, Wei Yi, Bryan L. Roth, Yan Zhang, H. Eric Xu
https://doi.org/10.1038/s41422-021-00482-0
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Structure-based development of three- and four-antibody cocktails against SARS-CoV-2 via multiple mechanisms

Yao Sun, Lei Wang, Rui Feng, Nan Wang, Yuxi Wang, Dandan Zhu, Xiaorui Xing, Peng Yang, Yanjun Zhang, Weimin Li, Xiangxi Wang
https://doi.org/10.1038/s41422-021-00497-7
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CORRIGENDA

Author Correction: A novel pathway regulates social hierarchy via lncRNA AtLAS and postsynaptic synapsin IIb

Mei Ma, Wan Xiong, Fan Hu, Man-Fei Deng, Xian Huang, Jian-Guo Chen, Heng-Ye Man, Youming Lu, Dan Liu, Ling-Qiang Zhu
https://doi.org/10.1038/s41422-021-00492-y
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