Cell Research

Volume 34 Issue 5, May 2024

The image illustrates a Chinese historical story, depicting Taigong Jiang fishing with his hook, reminiscent of the innovative proximity labeling tool, PhastID. PhastID identifies ATP6AP1, an unconventional GEF of Rheb. The C-tail at the end of ATP6AP1 can be used as a switch for Rheb to regulate the activation of mTORC1 signaling. Just as the two different states of the fish in the image, activating Rheb or not has distinct impacts on cellular functions. See page 355–369 by Ran Feng et al. for details.

RESEARCH HIGHLIGHTS

Treating insomnia with 40 Hz light flicker

P. Lorenzo Bozzelli, Li-Huei Tsai
https://doi.org/10.1038/s41422-024-00948-x
Full Text | PDF | Abstract

Amino acid availability governs mTOR ubiquitination

Xiaoming Dai, Peiqiang Yan, Wenyi Wei
https://doi.org/10.1038/s41422-023-00910-3
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Chromatin compartments at DNA double-stranded breaks

Jaewon Min, Jean Gautier
https://doi.org/10.1038/s41422-023-00912-1
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T follicular regulatory cells keep B cell-directed autoreactivity in check

Filipa Ribeiro, Luis Graca
https://doi.org/10.1038/s41422-024-00941-4
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A perfect storm: sleep loss causes systemic inflammation and death

Andrew D. Nguyen, Paula Carvalho Costa, David M. Raizen
https://doi.org/10.1038/s41422-023-00924-x
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The new horizon of plant auxin signaling via cell-surface co-receptors

Jen Sheen
https://doi.org/10.1038/s41422-023-00921-0
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ORIGINAL ARTICLES

Multiple cancer cell types release LIF and Gal3 to hijack neural signals

Qun Xu, Ying Cao, Fanni Kong, Jiaqi Liu, Xin Chen, Yifei Zhao, Chin-Hui Lai, Xin Zhou, Hao Hu, Wei Fu, Jian Chen, Jing Yang
https://doi.org/10.1038/s41422-024-00946-z
Full Text | PDF | Abstract | Open Access

The rapid proximity labeling system PhastID identifies ATP6AP1 as an unconventional GEF for Rheb

Ran Feng, Feng Liu, Ruofei Li, Zhifen Zhou, Zhuoheng Lin, Song Lin, Shengcheng Deng, Yingying Li, Baoting Nong, Ying Xia, Zhiyi Li, Xiaoqin Zhong, Shuhan Yang, Gang Wan, Wenbin Ma, Su Wu, Zhou Songyang
https://doi.org/10.1038/s41422-024-00938-z
Full Text | PDF | Abstract | Open Access

Discovery and structural mechanism of DNA endonucleases guided by RAGATH-18-derived RNAs

Kuan Ren, Fengxia Zhou, Fan Zhang, Mingyu Yin, Yuwei Zhu, Shouyu Wang, Yan Chen, Tengjin Huang, Zixuan Wu, Jiale He, Anqi Zhang, Changyou Guo, Zhiwei Huang
https://doi.org/10.1038/s41422-024-00952-1
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LETTERS TO THE EDITOR

CAR-Toner: an AI-driven approach for CAR tonic signaling prediction and optimization

Shizhen Qiu, Jian Chen, Tao Wu, Li Li, Gang Wang, Haitao Wu, Xianmin Song, Xuesong Liu, Haopeng Wang
https://doi.org/10.1038/s41422-024-00936-1
Full Text | PDF | Abstract | Open Access