RESEARCH HIGHLIGHTS

Peripheral cancer remodeling of central neural system

Gray Umbach, Shawn L. Hervey-Jumper
https://doi.org/10.1038/s41422-024-00960-1
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ATP6AP1 was Phast-ID’ed as a long-sought GEF for Rheb

Song Li, Xinxing Ouyang, Bing Su
https://doi.org/10.1038/s41422-024-00967-8
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Decoding T cell state-specific regulomes in cancer

Giulia Escobar, Ana C. Anderson
https://doi.org/10.1038/s41422-024-00926-3
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A tale of two calcium channels: structural pharmacology of Cav2.1 and Cav3.2

Laurent Ferron, Gerald W. Zamponi
https://doi.org/10.1038/s41422-024-00961-0
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Cytolytic too: Granzyme B-expressing human ILC2s mediate tumor rejection

Hergen Spits, Jenny Mjösberg
https://doi.org/10.1038/s41422-024-00937-0
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The hidden face of GluD1 at inhibitory synapses

Masayuki Itoh, Michisuke Yuzaki
https://doi.org/10.1038/s41422-024-00931-6
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ORIGINAL ARTICLES

Targeting pro-inflammatory T cells as a novel therapeutic approach to potentially resolve atherosclerosis in humans

Lin Fan, Junwei Liu, Wei Hu, Zexin Chen, Jie Lan, Tongtong Zhang, Yang Zhang, Xianpeng Wu, Zhiwei Zhong, Danyang Zhang, Jinlong Zhang, Rui Qin, Hui Chen, Yunfeng Zong, Jianmin Zhang, Bing Chen, Jun Jiang, Jifang Cheng, Jingyi Zhou, Zhiwei Gao, Zhenjie Liu, Ying Chai, Junqiang Fan, Pin Wu, Yinxuan Chen, Yuefeng Zhu, Kai Wang, Ying Yuan, Pintong Huang, Ying Zhang, Huiqin Feng, Kaichen Song, Xun Zeng, Wei Zhu, Xinyang Hu, Weiwei Yin, Wei Chen, Jian’an Wang
https://doi.org/10.1038/s41422-024-00945-0
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Structural insights into human exon-defined spliceosome prior to activation

Wenyu Zhang, Xiaofeng Zhang, Xiechao Zhan, Rui Bai, Jianlin Lei, Chuangye Yan, Yigong Shi
https://doi.org/10.1038/s41422-024-00949-w
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Structural basis for human Cav3.2 inhibition by selective antagonists

Jian Huang, Xiao Fan, Xueqin Jin, Chen Lyu, Qinmeng Guo, Tao Liu, Jiaofeng Chen, Amaël Davakan, Philippe Lory, Nieng Yan
https://doi.org/10.1038/s41422-024-00959-8
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LETTERS TO THE EDITOR

APOE3ch alleviates Aβ and tau pathology and neurodegeneration in the human APP^NL-G-F cerebral organoid model of Alzheimer’s disease

Hang Liu, Fan Mei, Rongrong Ye, Xinyu Han, Shudan Wang, Yan Ding, Yun Zhi, Keliang Pang, Wei Guo, Bai Lu
https://doi.org/10.1038/s41422-024-00957-w
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Structural basis for different ω-agatoxin IVA sensitivities of the P-type and Q-type Ca_v2.1 channels

Zhangqiang Li, Ye Cong, Tong Wu, Tongtong Wang, Xinyao Lou, Xinyu Yang, Nieng Yan
https://doi.org/10.1038/s41422-024-00940-5
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Substrate and drug recognition mechanisms of SLC19A3

Yu Dang, Tianyi Zhang, Shabareesh Pidathala, Guopeng Wang, Yijie Wang, Nanhao Chen, Chen Song, Chia-Hsueh Lee, Zhe Zhang
https://doi.org/10.1038/s41422-024-00951-2
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CORRIGENDA

Author Correction: Substrate and drug recognition mechanisms of SLC19A3

Yu Dang, Tianyi Zhang, Shabareesh Pidathala, Guopeng Wang, Yijie Wang, Nanhao Chen, Chen Song, Chia-Hsueh Lee, Zhe Zhang
https://doi.org/10.1038/s41422-024-00953-0
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