Volume 33, No 11, Nov 2023

ISSN: 1001-0602 
EISSN: 1748-7838  
2020 impact factor 25.617*  
(Clarivate Analytics, 2021)

About the cover

This cover portrays a flowing river, symbolizing the aging of a mother, surrounded by jujube and lotus plants. The seeds of these plants, standing as symbols of having many children, are traditionally given as gifts to newlyweds in Chinese culture to bestow blessings of fertility. Within the river, there are mitochondria undergoing shifts from tubular to donut-shaped structures as the mother ages. These mitochondria, inherited by the offspring, have enduring impacts on their trait formations. See page 821–834 by Runshuai Zhang et al. for details.

Advanced Online Publication: 5 Dec 2023

RESEARCH HIGHLIGHTS

A precision counterstrike on central nervous system autoimmunity

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Current Issue: Vol.33 (Nov 2023)

RESEARCH HIGHLIGHTS

RHIMoving fibrils of death
Lysine metabolism at the nexus of crotonylation and tumor immunity
How CHKing ROS signaling preserves genomic integrity
Accelerated transcriptional elongation during aging impairs longevity
GPCRs and β-arrestins — an on-off relationship

ORIGINAL ARTICLES

Maternal aging increases offspring adult body size via transmission of donut-shaped mitochondria
Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate
HSPA8 acts as an amyloidase to suppress necroptosis by inhibiting and reversing functional amyloid formation
Visualizing the nucleoplasmic maturation of human pre-60S ribosomal particles

LETTERS TO THE EDITOR

scNanoCOOL-seq: a long-read single-cell sequencing method for multi-omics profiling within individual cells
Platelet and myeloid lineage biases of transplanted single perinatal mouse hematopoietic stem cells
Development of a highly-efficient erythrocyte-drug covalent conjugation platform and its use in treating thrombotic disorders