Volume 31, No 11, Nov 2021

ISSN: 1001-0602 
EISSN: 1748-7838  
2020 impact factor 25.617*  
(Clarivate Analytics, 2021)

About the cover

The SARS-CoV-2 attacks host cells offensively via the respiratory system. In the asymptomatic subjects, the immune cells are active and finally kill the virus (right); whereas in the presymptomatic subjects, the immune cells are slack, the virus evades the attack of the immune system and amplifies quickly, and eventually causes the host to suffer from COVID-19 (left). The image is designed by Shanhe Yu and edited by Lehua Huang. See page 1148-1162 by Shanhe Yu et al. for details.

Advanced Online Publication: 26 Oct 2021

ORIGINAL ARTICLES

Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms

K_2P18.1 translates T cell receptor signals into thymic regulatory T cell development

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Current Issue: Vol.31 (Nov 2021)

RESEARCH HIGHLIGHTS

Tracing the origins of SARS-CoV-2: lessons learned from the past
ERASE: a novel nucleic-acid based antiviral mechanism
The reinvention of potato
Timing vaccination against SARS-CoV-2

ORIGINAL ARTICLES

Distinct immune signatures discriminate between asymptomatic and presymptomatic SARS-CoV-2pos subjects
Structural insights into ligand recognition and activation of the melanocortin-4 receptor
Structures of active melanocortin-4 receptor–Gs-protein complexes with NDP-α-MSH and setmelanotide
Tumor-conditional IL-15 pro-cytokine reactivates anti-tumor immunity with limited toxicity
NudCL2 is an autophagy receptor that mediates selective autophagic degradation of CP110 at mother centrioles to promote ciliogenesis

LETTERS TO THE EDITOR

Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2
Time of day influences immune response to an inactivated vaccine against SARS-CoV-2
Nuclear translocation of the 4-pass transmembrane protein Tspan8

CORRIGENDA

Author Correction: Interferon-armed RBD dimer enhances the immunogenicity of RBD for sterilizing immunity against SARS-CoV-2
Author Correction: Mechanical activation of spike fosters SARS-CoV-2 infection