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ISSN: 1001-0602
EISSN: 1748-7838
2020 impact factor 25.617*
(Clarivate Analytics, 2021)
About the cover
The artwork references history by depicting the concept of the Confucian “Doctrine of the Mean”. Tilting vessel, also known as yòu zuò zhī qì, is an ancient Chinese vessel that needs to be filled with an appropriate amount of water to maintain its upright position. Overfilling or underfilling the vessel can render it unstable. Likewise, CAR tonic signaling must be fine-tuned to ensure that it is neither too weak nor too robust, thereby optimizing CAR-T cell fitness. See page 341–354 by Jian Chen et al. for details.
ORIGINAL ARTICLES
Lin28a maintains a subset of adult muscle stem cells in an embryonic-like stateRESEARCH HIGHLIGHTS
Positively charged patches: tonic for CAR fitnessORIGINAL ARTICLES
Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitnessLETTERS TO THE EDITOR
H3K4me2/3 modulate the stability of RNA polymerase II pausing
