Volume 32, No 9, Sep 2022

ISSN: 1001-0602 
EISSN: 1748-7838  
2020 impact factor 25.617*  
(Clarivate Analytics, 2021)

About the cover

Nucleosome remodeling of the paternal genome during the first 12 h after fertilization in mice. The knotted ropes represent chromatins in the nucleus. In the first 3 h after fertilization, the protamine (pink knots) on paternal DNA was replaced by histone (yellow knots). Then the nucleosome positioning pattern was continually rebuilt to form nucleosome depletion regions at promoters and transcription factor binding sites, which were represented by more complex knots. See page 801-813 by Chenfei Wang et al. for details.

Advanced Online Publication: 15 Sep 2022

RESEARCH HIGHLIGHTS

A structural platform for B cell receptor signaling

Read more

Current Issue: Vol.32 (Sep 2022)

RESEARCH HIGHLIGHTS

Shaping the sinuses: a novel Krt14+Ctsk+ cell lineage driving regenerative bone formation
Human adult hippocampal neurogenesis is back, again?
R-2-HG assists IDH1-mutant solid tumors by promoting angiogenesis
Efficient replication of human nuclear DNA
Treatment for giant congenital nevi moves a step closer

ORIGINAL ARTICLES

Dynamic nucleosome organization after fertilization reveals regulatory factors for mouse zygotic genome activation
A novel lineage of osteoprogenitor cells with dual epithelial and mesenchymal properties govern maxillofacial bone homeostasis and regeneration after MSFL
Hetero-bivalent nanobodies provide broad-spectrum protection against SARS-CoV-2 variants of concern including Omicron
Glutamate drives ‘local Ca2+ release’ in cardiac pacemaker cells

LETTERS TO THE EDITOR

Structural insights into ligand binding and activation of the human thyrotropin-releasing hormone receptor
Structural insights into thyrotropin-releasing hormone receptor activation by an endogenous peptide agonist or its orally administered analogue
A broadly neutralizing antibody against SARS-CoV-2 Omicron variant infection exhibiting a novel trimer dimer conformation in spike protein binding

CORRIGENDA

Author Correction: Formative pluripotent stem cells show features of epiblast cells poised for gastrulation