Volume 34, No 10, Oct 2024

ISSN: 1001-0602 
EISSN: 1748-7838  
2020 impact factor 25.617*  
(Clarivate Analytics, 2021)

About the cover

The image depicts a story that happened during the Warring States. A senior general named Lian Po, loyal to King of the Zhao State, was given a chunk of meat and became re-energized. The cover paper reports that the catabolism of the amino acid glutamine can replenish energy when glucose is depleted. See page 683–706 by Mengqi Li et al. for details.

Advanced Online Publication: 2 Sep 2024

LETTERS TO THE EDITOR

Mechanistic insights of substrate transport and inhibitor binding revealed by high-resolution structures of human norepinephrine transporter

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Current Issue: Vol.34 (Oct 2024)

RESEARCH HIGHLIGHTS

Illuminating nucleosome interactions
No pain, no gain — how nociceptors orchestrate tissue repair
Pyroptosis: palmitoylation regulates GSDMD activation and pore formation
Tumor microenvironment squeezes out the juice from T cells
All-in-one Hangzhou Protocol: killing four birds with one stone
Illuminating the path to pancreatic cancer

ORIGINAL ARTICLES

AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine
Structural basis for linker histone H5–nucleosome binding and chromatin fiber compaction
Structural basis of tethered agonism and G protein coupling of protease-activated receptors

LETTERS TO THE EDITOR

Bitter taste receptor TAS2R14 activation and G protein assembly by an intracellular agonist
Deletion of V483 in the spike confers evolutionary advantage on SARS-CoV-2 for human adaptation and host-range expansion after a prolonged pandemic
Molecular insights into the inhibition of proton-activated chloride channel by transfer RNA