Advanced Search

Submit Manuscript

Volume 34, No 5, May 2024

ISSN: 1001-0602 
EISSN: 1748-7838  
2020 impact factor 25.617*  
(Clarivate Analytics, 2021)

About the cover

The image illustrates a Chinese historical story, depicting Taigong Jiang fishing with his hook, reminiscent of the innovative proximity labeling tool, PhastID. PhastID identifies ATP6AP1, an unconventional GEF of Rheb. The C-tail at the end of ATP6AP1 can be used as a switch for Rheb to regulate the activation of mTORC1 signaling. Just as the two different states of the fish in the image, activating Rheb or not has distinct impacts on cellular functions. See page 355–369 by Ran Feng et al. for details.