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Volume 32, No 9, Sep 2022

ISSN: 1001-0602 
EISSN: 1748-7838  
2020 impact factor 25.617*  
(Clarivate Analytics, 2021)

About the cover

Nucleosome remodeling of the paternal genome during the first 12 h after fertilization in mice. The knotted ropes represent chromatins in the nucleus. In the first 3 h after fertilization, the protamine (pink knots) on paternal DNA was replaced by histone (yellow knots). Then the nucleosome positioning pattern was continually rebuilt to form nucleosome depletion regions at promoters and transcription factor binding sites, which were represented by more complex knots. See page 801-813 by Chenfei Wang et al. for details.