Volume 32, No 5, May 2022

ISSN: 1001-0602 
EISSN: 1748-7838  
2020 impact factor 25.617*  
(Clarivate Analytics, 2021)

About the cover

The image describes an ancient Chinese myth “Hou Yi Shoots the Suns”, wherein Hou Yi was tasked to save people by shooting nine extra buring suns. Voltage-gated H+ channel Hv1 was unexpectedly identified in the sensory neurons; inhibiting neuroinflammation (symbolized by the burning suns) by targeting Hv1 genetically or pharmacologically using a newly-discovered inhibitor (symbolized by arrow) alleviates chronic inflammatory pain and morphine-induced adverse side effects. The cover art is contributed by Keyu Yu. See page 461–476 by Qiansen Zhang et al. for details.

Advanced Online Publication: 6 Apr 2022

RESEARCH HIGHLIGHTS

A gut feeling: diet-sensing mesenchymal cells regulate intestinal stem cell function

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Current Issue: Vol.32 (May 2022)

RESEARCH HIGHLIGHTS

Cuproptosis: a copper-triggered modality of mitochondrial cell death
Targeting Hv1 proton channel for pain control
Lipid nanoparticle-mRNA: another step in the fight against COVID-19
Banking on metabolomics for novel therapies in TNBC

ORIGINAL ARTICLES

Evolutionarily conservative and non-conservative regulatory networks during primate interneuron development revealed by single-cell RNA and ATAC sequencing
Near-atomic structure of the inner ring of the Saccharomyces cerevisiae nuclear pore complex
Cryo-EM structure of the inner ring from the Xenopus laevis nuclear pore complex
Inhibiting Hv1 channel in peripheral sensory neurons attenuates chronic inflammatory pain and opioid side effects
Comprehensive metabolomics expands precision medicine for triple-negative breast cancer

LETTERS TO THE EDITOR

Immune escape by SARS-CoV-2 Omicron variant and structural basis of its effective neutralization by a broad neutralizing human antibody VacW-209
The P132H mutation in the main protease of Omicron SARS-CoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition
Structures of human bile acid exporter ABCB11 reveal a transport mechanism facilitated by two tandem substrate-binding pockets