Volume 31, No 6, Jun 2021

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
2019 impact factor 20.507*  
(Clarivate Analytics, 2020)

About the cover

When synthetic biology meets RNAi therapy. Programmable genetic circuits (multicolor circles) utilize the liver as tissue chassis and a biogenerator, which can continuously produce and assemble exosome-encapsulated siRNAs (orange balls with spikes) for targeted delivery to multiple organs. See page 631–648 by Zheng Fu et al. for details.

Advanced Online Publication: 8 Jun 2021

LETTERS TO THE EDITOR

Enhancing prime editing by Csy4-mediated processing of pegRNA

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Current Issue: Vol.31 (Jun 2021)

RESEARCH HIGHLIGHTS

3D genome encoded by LINE and SINE repeats
A spatial map out of place
Panning for brain antigens in dural sinuses
LETN and NPM1 tango in human nucleoli
To learn something new, do something new

ORIGINAL ARTICLES

Homotypic clustering of L1 and B1/Alu repeats compartmentalizes the 3D genome
In vivo self-assembled small RNAs as a new generation of RNAi therapeutics

LETTERS TO THE EDITOR

Structural basis of human α7 nicotinic acetylcholine receptor activation
Structural basis for the different states of the spike protein of SARS-CoV-2 in complex with ACE2
The basis of a more contagious 501Y.V1 variant of SARS-CoV-2