RESEARCH HIGHLIGHTS

WildCARDs: Inflammatory caspases directly detect LPS

Jon Alan Hagar, Youssef Aachoui and Edward Axel Miao
10.1038/cr.2014.128
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Another twist in the histone memory code

Sheena Josselyn and Paul W Frankland
10.1038/cr.2014.134
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Pseudouridine in a new era of RNA modifications

Boxuan Simen Zhao and Chuan He
10.1038/cr.2014.143
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Adenosine activates thermogenic adipocytes

Amy K Rines, Francisco Verdeguer and Pere Puigserver
10.1038/cr.2014.157
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ORIGINAL ARTICLES

Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B

Pengfei Yuan, Hongmin Zhang, Changzu Cai, Shiyou Zhu, Yuexin Zhou, Xiaozhou Yang, Ruina He, Chan Li, Shengjie Guo, Shan Li, Tuxiong Huang, Gregorio Perez-Cordon, Hanping Feng and Wensheng Wei
10.1038/cr.2014.169
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GATA family members as inducers for cellular reprogramming to pluripotency

Jian Shu, Ke Zhang, Minjie Zhang, Anzhi Yao, Sida Shao, Fengxia Du, Caiyun Yang, Wenhan Chen, Chen Wu, Weifeng Yang, Yingli Sun and Hongkui Deng
10.1038/cr.2015.6
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RAG1-mediated ubiquitylation of histone H3 is required for chromosomal V(D)J recombination

Zimu Deng, Haifeng Liu and Xiaolong Liu
10.1038/cr.2015.1
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MIWI and piRNA-mediated cleavage of messenger RNAs in mouse testes

Peng Zhang, Jun-Yan Kang, Lan-Tao Gou, Jiajia Wang, Yuanchao Xue, Geir Skogerboe, Peng Dai, Da-Wei Huang, Runsheng Chen, Xiang-Dong Fu, Mo-Fang Liu and Shunmin He
10.1038/cr.2015.4
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Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25

Dalil Hannani1,2,3,*, Marie Vétizou1,2,3,*, David Enot1,4,5, Sylvie Rusakiewicz1,2,6, Nathalie Chaput1,2,6, David Klatzmann7,8, Nicolas Jacquelot1,2,3, Nadège Vimond1,2,6, Salem Chouaib9, Christine Mateus1,10, James P Allison11, Antoni Ribas12, Jedd D Wolchok13, Jianda Yuan13, Philip Wong13, Michael Postow13, Andrzej Mackiewicz, Jacek Mackiewicz, Dirk Schadendorff, Dirk Jaeger, Alan J Korman, Keith Bahjat, Michele Maio, Luana Calabro, Michele WL Teng, Mark J Smyth, Alexander Eggermont, Caroline Robert, Guido Kroemer and Laurence Zitvogel
10.1038/cr.2015.3
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Tyrosine 370 phosphorylation of ATM positively regulates DNA damage response

Hong-Jen Lee, Li Lan, Guang Peng, Wei-Chao Chang, Ming-Chuan Hsu, Ying-Nai Wang, Chien-Chia Cheng, Leizhen Wei, Satoshi Nakajima, Shih-Shin Chang, Hsin-Wei Liao, Chung-Hsuan Chen, Martin Lavin, K Kian Ang, Shiaw-Yih Lin and Mien-Chie Hung
10.1038/cr.2015.8
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Cationic nanocarriers induce cell necrosis through impairment of Na+/K+-ATPase and cause subsequent inflammatory response

Xiawei Wei, Bin Shao, Zhiyao He, Tinghong Ye, Min Luo, Yaxiong Sang, Xiao Liang, Wei Wang, Shuntao Luo, Shengyong Yang, Shuang Zhang, Changyang Gong, Maling Gou, Hongxing Deng, Yinglan Zhao, Hanshuo Yang, Senyi Deng, Chengjian Zhao, Li Yang, Zhiyong Qian, Jiong Li, Xun Sun, Jiahuai Han, Chengyu Jiang, Min Wu and Zhirong Zhang
10.1038/cr.2015.9
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LETTERS TO THE EDITOR

Large-field high-resolution two-photon digital scanned light-sheet microscopy

Weijian Zong, Jia Zhao, Xuanyang Chen, Yuan Lin, Huixia Ren, Yunfeng Zhang, Ming Fan, Zhuan Zhou, Heping Cheng, Yujie Sun and Liangyi Chen
10.1038/cr.2014.124
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One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system

Haifeng Wan, Chunjing Feng, Fei Teng, Shihua Yang, Baoyang Hu, Yuyu Niu, Andy Peng Xiang, Weizhen Fang, Weizhi Ji, Wei Li, Xiaoyang Zhao and Qi Zhou
10.1038/cr.2014.158
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Germline acquisition of Cas9/RNA-mediated gene modifications in monkeys

Yongchang Chen, Yiqiang Cui, Bin Shen, Yuyu Niu, Xiaoyang Zhao, Lei Wang, Jianying Wang, Wei Li, Qi Zhou, Weizhi Ji, Jiahao Sha and Xingxu Huang
10.1038/cr.2014.167
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ADDENDUM

Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis

Lan-Tao Gou, Peng Dai, Jian-Hua Yang, Yuanchao Xue, Yun-Ping Hu, Yu Zhou, Jun-Yan Kang, Xin Wang, Hairi Li, Min-Min Hua, Shuang Zhao, Si-Da Hu, Li-Gang Wu, Hui-Juan Shi, Yong Li, Xiang-Dong Fu, Liang-Hu Qu, En-Duo Wang and Mo-Fang Liu
10.1038/cr.2014.41
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