RESEARCH HIGHLIGHTS

The generation of sex cells

Alessia Deglincerti and Ali H Brivanlou
10.1038/cr.2015.18
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Personalized one-two punches for lung cancer

Hannah A Scarborough, Paul A Bunn Jr and James DeGregori
10.1038/cr.2014.168
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Regenerative medicine: targeted genome editing in vivo

Lixia Wang, Jun Wu, Weiwei Fang, Guang-Hui Liu and Juan Carlos Izpisua Belmonte
10.1038/cr.2015.11
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DUBA-UBR5 axis: other than transactivation

Chuan Wu, Zuojia Chen and Vijay K Kuchroo
10.1038/cr.2015.13
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ORIGINAL ARTICLES

CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development

Tao Tu, Chunxia Zhang, Huiwen Yan, Yongting Luo, Ruirui Kong, Pushuai Wen, Zhongde Ye, Jianan Chen, Jing Feng, Feng Liu, Jane Y Wu and Xiyun Yan
10.1038/cr.2015.15
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The Integrator complex controls the termination of transcription at diverse classes of gene targets

Jeffrey R Skaar, Andrea L Ferris, Xiaolin Wu, Anita Saraf, Kum Kum Khanna, Laurence Florens, Michael P Washburn, Stephen H Hughes and Michele Pagano
10.1038/cr.2015.19
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Recurrent gain-of-function USP8 mutations in Cushing s disease

Zeng-Yi Ma, Zhi-Jian Song, Jian-Hua Chen, Yong-Fei Wang, Shi-Qi Li, Liang-Fu Zhou, Ying Mao, Yi-Ming Li, Rong-Gui Hu, Zhao-Yun Zhang, Hong-Ying Ye, Ming Shen, Xue-Fei Shou, Zhi-Qiang Li, Hong Peng, Qing-Zhong Wang, Dai-Zhan Zhou, Xiao-Lan Qin, Jue Ji, Jie Zheng, Hong Chen, Yin Wang, Dao-Ying Geng, Wei-Jun Tang, Chao-Wei Fu, Zhi-Feng Shi, Yi-Chao Zhang, Zhao Ye, Wen-Qiang He, Qi-Lin Zhang, Qi-Sheng Tang, Rong Xie, Jia-Wei Shen, Zu-Jia Wen, Juan Zhou, Tao Wang, Shan Huang, Hui-Jia Qiu, Ni-Dan Qiao, Yi Zhang, Li Pan, Wei-Min Bao, Ying-Chao Liu, Chuan-Xin Huang, Yong-Yong Shi and Yao Zhao
10.1038/cr.2015.20
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FXYD2, a γ subunit of Na⁺,K⁺-ATPase, maintains persistent mechanical allodynia induced by inflammation

Feng Wang, Bing Cai, Kai-Cheng Li, Xu-Ye Hu, Ying-Jin Lu, Qiong Wang, Lan Bao and Xu Zhang
10.1038/cr.2015.12
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LncRNA Dum interacts with Dnmts to regulate Dppa2 expression during myogenic differentiation and muscle regeneration

Lijun Wang, Yu Zhao, Xichen Bao, Xihua Zhu, Yvonne Ka-yin Kwok, Kun Sun, Xiaona Chen, Yongheng Huang, Ralf Jauch, Miguel A Esteban, Hao Sun and Huating Wang
10.1038/cr.2015.21
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p53 isoform Δ113p53/Δ133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage

Lu Gong, Hongjian Gong, Xiao Pan, Changqing Chang, Zhao Ou, Shengfan Ye, Le Yin, Lina Yang, Ting Tao, Zhenhai Zhang, Cong Liu, David P Lane, Jinrong Peng and Jun Chen
10.1038/cr.2015.22
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EWI-2 negatively regulates TGF-β signaling leading to altered melanoma growth and metastasis

Hong-Xing Wang, Chandan Sharma, Konstantin Knoblich, Scott R Granter and Martin E Hemler
10.1038/cr.2015.17
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LETTERS TO THE EDITOR

Base-resolution maps of 5-formylcytosine and 5-carboxylcytosine reveal genome-wide DNA demethylation dynamics

Xingyu Lu, Dali Han, Zhao Boxuan Simen, Chun-Xiao Song, Li-Sheng Zhang, Louis C Doré and Chuan He
10.1038/cr.2015.5
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Characterization and target identification of a DNA aptamer that labels pluripotent stem cells

Zhonggang Hou, Susanne Meyer, Nicholas E Propson, Jeff Nie, Peng Jiang, Ron Stewart and James A Thomson
10.1038/cr.2015.7
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A chemical genetic approach to probe the function of PINK1 in regulating mitochondrial dynamics

Conggang Zhang, Schuyler Lee, Yinghua Peng, Eric Bunker, Chong Shen, Emilie Giaime, Jie Shen, Jingshi Shen, Zongyao Zhou and Xuedong Liu
10.1038/cr.2014.159
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CORRIGENDA

Structural basis of AMPK regulation by adenine nucleotides and glycogen

Xiaodan Li, Lili Wang, X Edward Zhou, Jiyuan Ke, Parker W de Waal, Xin Gu, M H Eileen Tan, Dongye Wang, Donghai Wu, H Eric Xu and Karsten Melcher
10.1038/cr.2015.27
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Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25

Dalil Hannani, Marie Vétizou, David Enot, Sylvie Rusakiewicz, Nathalie Chaput, David Klatzmann, Melanie Desbois, Nicolas Jacquelot, Nadège Vimond, Salem Chouaib, Christine Mateus, James P Allison, Antoni Ribas, Jedd D Wolchok, Jianda Yuan, Philip Wong, Michael Postow, Andrzej Mackiewicz, Jacek Mackiewicz, Dirk Schadendorff, Dirk Jaeger, Alan J Korman, Keith Bahjat, Michele Maio, Luana Calabro, Michele WL Teng, Mark J Smyth, Alexander Eggermont, Caroline Robert, Guido Kroemer and Laurence Zitvogel
10.1038/cr.2015.28
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