RESEARCH HIGHLIGHTS

The DUB blade goes snicker-snack: Novel ubiquitin cleavage by a Legionella effector protein

Judith A Ronau and Mark Hochstrasser
10.1038/cr.2017.80
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Tissue-resident memory T cells live off the fat of the land

J Michael Stolley and David Masopust
10.1038/cr.2017.49
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Remote control of BBB: A tale of exosomes and microRNA

Zhen Zhao and Berislav V Zlokovic
10.1038/cr.2017.71
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Beyond growth signaling: Paneth cells metabolically support ISCs

Talya L Dayton and Hans Clevers
10.1038/cr.2017.59
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ORIGINAL ARTICLES

Alternate binding modes of anti-CRISPR viral suppressors AcrF1/2 to Csy surveillance complex revealed by cryo-EM structures

Ruchao Peng, Ying Xu, Tengfei Zhu, Ningning Li, Jianxun Qi, Yan Chai, Min Wu, Xinzheng Zhang, Yi Shi, Peiyi Wang, Jiawei Wang1, Ning Gao and George Fu Gao
10.1038/cr.2017.79
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A unique deubiquitinase that deconjugates phosphoribosyl-linked protein ubiquitination

Jiazhang Qiu, Kaiwen Yu, Xiaowen Fei, Yao Liu, Ernesto S Nakayasu, Paul D Piehowski, Jared B Shaw, Kedar Puvar, Chittaranjan Das, Xiaoyun Liu and Zhao-Qing Luo
10.1038/cr.2017.66
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Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity

Bing Xu, Yu Zhang, Xu-Fei Du, Jia Li, Hua-Xing Zi, Ji-Wen Bu, Yong Yan, Hua Han and Jiu-Lin Du
10.1038/cr.2017.62
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Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription

Wei Wei, Xiaoguang Liu, Jiwei Chen, Shennan Gao, Lu Lu, Huifang Zhang, Guangjin Ding, Zhiqiang Wang, Zhongzhou Chen, Tieliu Shi, Jiwen Li, Jianjun Yu and Jiemin Wong
10.1038/cr.2017.68
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Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer

Rui Kang, Yangchun Xie, Qiuhong Zhang, Wen Hou, Qingping Jiang, Shan Zhu, Jinbao Liu, Dexing Zeng, Haichao Wang, David L Bartlett, Timothy R Billiar, Herbert J Zeh III, Michael T Lotze and Daolin Tang
10.1038/cr.2017.51
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One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs

Erwei Zuo, Yi-Jun Cai, Kui Li, Yu Wei, Bang-An Wang, Yidi Sun, Zhen Liu, Jiwei Liu, Xinde Hu, Wei Wei, Xiaona Huo, Linyu Shi, Cheng Tang, Dan Liang, Yan Wang, Yan-Hong Nie, Chen-Chen Zhang, Xuan Yao, Xing Wang, Changyang Zhou, Wenqin Ying, Qifang Wang, Ren-Chao Chen, Qi Shen, Guo-Liang Xu, Jinsong Li, Qiang Sun, Zhi-Qi Xiong and Hui Yang
10.1038/cr.2017.81
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LETTERS TO THE EDITOR

Global profiling of crotonylation on non-histone proteins

Weizhi Xu, Junhu Wan, Jun Zhan, Xueying Li, Huiying He, Zhaomei Shi and Hongquan Zhang
10.1038/cr.2017.60
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Optogenetic activation of dorsal raphe neurons rescues the autistic-like social deficits in Shank3 knockout mice

Junyu Luo, Qiru Feng, Liping Wei and Minmin Luo
10.1038/cr.2017.52
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The genetics of tiger pelage color variations

Xiao Xu, Gui-Xin Dong, Anne Schmidt-Küntzel, Xue-Li Zhang, Yan Zhuang, Run Fang, Xin Sun, Xue-Song Hu, Tian-You Zhang, Han-Dong Yang, De-Lu Zhang, Laurie Marker, Zheng-Fan Jiang, Ruiqiang Li and Shu-Jin Luo
10.1038/cr.2017.32
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