Cell Research

Volume 28 Issue 12, Dec 2018

The cover image illustrates that swordsmen (ROS-inducing drugs) are struggling against monsters (melanoma cells). However, when they are armed with iron robot (combined treatment of ROS-inducing drugs with iron), they easily destroy many monsters using a flame-thrower (ROS). Cover artwork is contributed by Xian-shuo Liu and Hui-ran Liu.See page 1171-1185 by Bo Zhou et al. for details.

RESEARCH HIGHLIGHTS

ALPK1: innate attraction to the sweetness of bacteria

Yansong Xue and Si Ming Man
https://doi.org/10.1038/s41422-018-0100-0
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New roles for RAD52 in DNA repair

Chaoyou Xue and Eric C. Greene
https://doi.org/10.1038/s41422-018-0105-8
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ORIGINAL ARTICLES

Structures of the human pre-catalytic spliceosome and its precursor spliceosome

Xiechao Zhan , Chuangye Yan , Xiaofeng Zhang , Jianlin Lei and Yigong Shi
https://doi.org/10.1038/s41422-018-0094-7
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The adult human testis transcriptional cell atlas

Jingtao Guo , Edward J. Grow , Hana Mlcochova , Geoffrey J. Maher, Cecilia Lindskog, Xichen Nie , Yixuan Guo ,Jina Yun , Long Cai , Robin Kim , Douglas T. Carrell, Anne Goriely , James M. Hotaling and Bradley R. Cairns
https://doi.org/10.1038/s41422-018-0099-2
Full Text | PDF | Abstract | Open Access

Cryo-EM reveals ligand induced allostery underlying InsP3R channel gating

Guizhen Fan , Mariah R. Baker , Zhao Wang, Alexander B. Seryshev , Steven J. Ludtke , Matthew L. Baker and Irina I. Serysheva
https://doi.org/10.1038/s41422-018-0108-5
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Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis

Bo Zhou , Jia-yuan Zhang , Xian-shuo Liu , Hang-zi Chen, Yuan-li Ai , Kang Cheng, Ru-yue Sun , Dawang Zhou, Jiahuai Han and Qiao Wu
https://doi.org/10.1038/s41422-018-0090-y
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Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade

Yiwei Wang , Yuxuan Jiang, Shan Ding , Jiawang Li , Ningjing Song , Yujing Ren, Danning Hong , Cai Wu, Bin Li , Feng Wang ,Wei He, Jiawei Wang and Ziqing Mei
https://doi.org/10.1038/s41422-018-0091-x
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LETTERS TO THE EDITOR

Cryo-EM structure of Type III-A CRISPR effector complex

Yangao Huo , Tao Li , Nan Wang , Qinghua Dong , Xiangxi Wang and Tao Jiang
https://doi.org/10.1038/s41422-018-0115-6
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Structural insights into Cas13b-guided CRISPR RNA maturation and recognition

Bo Zhang , Weiwei Ye, Yangmiao Ye , Huan Zhou , Abdullah F. U. H. Saeed , Jing Chen , Jinying Lin , Vanja Perčulija , Qi Chen , Chun-Jung Chen, Ming-Xian Chang , Muhammad Iqbal Choudhary and Songying Ouyang
https://doi.org/10.1038/s41422-018-0109-4
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