Cell Research

Volume 28 Issue 11, Nov 2018

N6-methyladenosine (m6A) mRNA modification enhances learning efficacy, and overdosed training can compensate for the effect of m6A insufficiency. Cover image shows two tortoises with different levels of m6A modifications (shown as the numbers of hexagons on their shells) are competing in a race, which is an analogy to learning process. The tortoise with more m6A races more easily with less steps. However, if the one with less m6A pays more effort, the initial disadvantage can be overcome, and the two tortoises can finish the match at the same time. See page 1050-1061 by Zeyu Zhang et al. for details.

EDITORIAL

Sanofi-Cell Research outstanding paper award of 2017

Editorial Office
https://doi.org/10.1038/s41422-018-0106-7
Full Text | PDF | Abstract

RESEARCH HIGHLIGHTS

A new STAT3 function: pH regulation

Yuxin Wang and George R. Stark
https://doi.org/10.1038/s41422-018-0098-3
Full Text | PDF | Abstract

Mitochondrial DNA synthesis fuels NLRP3 inflammasome

Rebecca C. Coll , Caroline L. Holley and Kate Schroder
https://doi.org/10.1038/s41422-018-0093-8
Full Text | PDF | Abstract

DH44 neurons: gut-brain amino acid sensors

Yu-Chieh David Chen and Anupama Dahanukar
https://doi.org/10.1038/s41422-018-0101-z
Full Text | PDF | Abstract

ORIGINAL ARTICLES

METTL3-mediated N6-methyladenosine mRNA modification enhances long-term memory consolidation

Zeyu Zhang , Meng Wang , Dongfang Xie, Zenghui Huang , Lisha Zhang , Ying Yang, Dongxue Ma , Wenguang Li, Qi Zhou , Yun-Gui Yang and Xiu-Jie Wang
https://doi.org/10.1038/s41422-018-0092-9
Full Text | PDF | Abstract | Open Access

A dynamic N6-methyladenosine methylome regulates intrinsic and acquired resistance to tyrosine kinase inhibitors

Fei Yan, Aref Al-Kali , Zijie Zhang , Jun Liu , Jiuxia Pang , Na Zhao , Chuan He , Mark R. Litzow and Shujun Liu
https://doi.org/10.1038/s41422-018-0097-4
Full Text | PDF | Abstract | Open Access

Accurate annotation of accessible chromatin in mouse and human primordial germ cells

Jingyi Li , Shijun Shen , Jiayu Chen , Wenqiang Liu , Xiaocui Li , Qianshu Zhu , Beiying Wang , Xiaolong Chen , Li Wu , Mingzhu Wang, Liang Gu , Hong Wang , Jiqing Yin , Cizhong Jiang and Shaorong Gao
https://doi.org/10.1038/s41422-018-0096-5
Full Text | PDF | Abstract

Pyruvate kinase M2 regulates homologous recombination-mediated DNA double-strand break repair

Steven T. Sizemore , Manchao Zhang, Ju Hwan Cho , Gina M. Sizemore , Brian Hurwitz , Balveen Kaur , Norman L. Lehman ,Michael C. Ostrowski, Pierre A. Robe , Weili Miao , Yinsheng Wang8, Arnab Chakravarti1 and Fen Xia2
https://doi.org/10.1038/s41422-018-0086-7
Full Text | PDF | Abstract | Open Access

Elimination of CD4lowHLA-G+ T cells overcomes castration-resistance in prostate cancer therapy

Chao Wang , Jiahuan Chen , Qianfei Zhang , Wang Li , Shengbo Zhang , Yanjie Xu , Fang Wang , Bing Zhang , Yan Zhang and Wei-Qiang Gao
https://doi.org/10.1038/s41422-018-0089-4
Full Text | PDF | Abstract

LETTERS TO THE EDITOR

H3K14me3 genomic distributions and its regulation by KDM4 family demethylases

Bin Zhao , Wenqi Xu, Bowen Rong , Guoyu Chen, Xuanjia Ye ,Ruofei Dai , Wenjing Li , Jiajia Chen , Jiajun Cai , Lei Song ,Zhao-Qing Luo , Rong Zeng , Yang Shi , Jing-Dong J. Han and Fei Lan
https://doi.org/10.1038/s41422-018-0095-6
Full Text | PDF | Abstract