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Table of Contents

Volume 30 Issue 1, Jan 2020

The cover implies that when the translation of the proteins en route to the ER (symbolized by the high speed train going through a tunnel) is stopped by a poly-A stalling sequence, this scenario will trigger ribosome UFMylation in the cell to lauch a translocation-associated protein quality control. See page 5-20 by Lihui Wang et al. for details.

RESEARCH HIGHLIGHTS

Cleaning up stalled ribosome-translocon complexes with ufmylation

Adele Xu and Maria Barna
https://doi.org/10.1038/s41422-019-0249-1
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A new checkpoint against ferroptosis

Deguang Liang, Liang Deng and Xuejun Jiang
https://doi.org/10.1038/s41422-019-0258-0
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ORIGINAL ARTICLES

UFMylation of RPL26 links translocation-associated quality control to endoplasmic reticulum protein homeostasis

Lihui Wang, Yue Xu1, Heather Rogers, Layla Saidi, Constance Tom Noguchi, Honglin Li, Jonathan Wilson Yewdell,Nicholas Raymond Guydosh and Yihong Ye
https://doi.org/10.1038/s41422-019-0236-6
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Guiding T lymphopoiesis from pluripotent stem cells by defined transcription factors

Rongqun Guo , Fangxiao Hu , Qitong Weng , Cui Lv , Hongling Wu, Lijuan Liu , Zongcheng Li ,Yang Zeng, Zhijie Bai, Mengyun Zhang , Yuting Liu , Xiaofei Liu , Chengxiang Xia , Tongjie Wang ,Peiqing Zhou , Kaitao Wang, Yong Dong , Yuxuan Luo, Xiangzhong Zhang, Yuxian Guan , Yang Geng , Juan Du, Yangqiu Li , Yu Lan , Jiekai Chen, Bing Liu and Jinyong Wang
https://doi.org/10.1038/s41422-019-0251-7
Full Text | PDF | Abstract | Open Access


Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer

Shuaishuai Teng, Yang Eric Li , Ming Yang1, Rui Qi, Yiming Huang, Qianyu Wang, Yanmei Zhang, Shanwen Chen, Shasha Li,Kequan Lin, Yang Cao, Qunsheng Ji, Qingyang Gu, Yujing Cheng, Zai Chang, Wei Guo , Pengyuan Wang, Ivan Garcia-Bassets,Zhi John Luand Dong Wang
https://doi.org/10.1038/s41422-019-0259-z
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Genomic landscape and genetic manipulation of the black soldier fly Hermetia illucens, a natural waste recycler

Shuai Zhan , Gangqi Fang , Minmin Cai, Zongqing Kou, Jun Xu, Yanghui Cao, Liang Bai, Yixiang Zhang, Yongmao Jiang , Xingyu Luo , Jian Xu , Xia Xu, Longyu Zheng, Ziniu Yu, Hong Yang, Zhijian Zhang, Sibao Wang, Jeffery K. Tomberlin ,Jibin Zhang and Yongping Huang
https://doi.org/10.1038/s41422-019-0252-6
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Crystal structure of plant PLDα1 reveals catalytic and regulatory mechanisms of eukaryotic phospholipase D

Jianxu Li, Fang Yu, Hui Guo, Renxue Xiong, Wenjing Zhang, Fangyuan He, Minhua Zhang and Peng Zhang

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Initiation of Parkinson’s disease from gut to brain by δ-secretase

Eun Hee Ahn, Seong Su Kang, Xia Liu, Guiqin Chen, Zhentao Zhang, Bindu Chandrasekharan, Ashfaqul M. Alam,Andrew S. Neish, Xuebing Cao and Keqiang Ye
https://doi.org/10.1038/s41422-019-0241-9
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LETTERS TO THE EDITOR

Crystal structure of heliorhodopsin 48C12

Yang Lu, X. Edward Zhou, Xiang Gao, Na Wang, Ruixue Xia,Zhenmei Xu, Yu Leng, Yuying Shi, Guangfu Wang,Karsten Melcher, H. Eric Xu and Yuanzheng He
https://doi.org/10.1038/s41422-019-0266-0
Full Text | PDF | Abstract | Open Access


Joint utilization of genetic analysis and semi-cloning technology reveals a digenic etiology of Müllerian anomalies

Lingbo Wang , Ying Zhang , Xiaoyi Fu,Shuangshuang Dong, Shuyan Tang , Ning Zhang ,Chengcheng Song , Nan Yang, Lin Zhang, Hongyan Wang ,Huijuan Shi, Li Jin, Feng Zhang , Jinsong Li and Keqin Hua
https://doi.org/10.1038/s41422-019-0243-7
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Hepatic spheroids derived from human induced pluripotent stem cells in bio-artificial liver rescue porcine acute liver failure

Sitong Chen, Jinglin Wang, Haozhen Ren, Yinan Liu,Chengang Xiang, Cheng Li, Shichun Lu, Yan Shi,Hongkui Deng and Xiaolei Shi
https://doi.org/10.1038/s41422-019-0261-5
Full Text | PDF | Abstract | Open Access