Cell Research

Volume 30 Issue 11, Nov 2020

Mn2+ pushes antitumor vehicles full speed ahead and revives immunotherapy in cancer patients. See page 966-979 by Mengze Lv et al. for details.

EDITORIAL

Sanofi-Cell Research outstanding paper award of 2019

Cell Research Editorial Team
https://doi.org/10.1038/s41422-020-00425-1
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RESEARCH HIGHLIGHTS

Inosine: novel microbiota-derived immunostimulatory metabolite

Guido Kroemer, Laurence Zitvogel
https://doi.org/10.1038/s41422-020-00417-1
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Twin peaks: finding fragile sites with MiDAS-seq

Thomas W. Glover, Thomas E. Wilson
https://doi.org/10.1038/s41422-020-0376-8
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When de novo-designed protein logics meet CAR-T therapies

Mingqi Xie, Peilong Lu
https://doi.org/10.1038/s41422-020-00419-z
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CAR T cells: from tinkering to rational design

Bernard Malissen
https://doi.org/10.1038/s41422-020-00420-6
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ORIGINAL ARTICLES

Single-cell transcriptomic analysis defines the interplay between tumor cells, viral infection, and the microenvironment in nasopharyngeal carcinoma

Shanzhao Jin, Ruoyan Li, Ming-Yuan Chen, Chao Yu, Lin-Quan Tang, Yan-Min Liu, Jiang-Ping Li, Yi-Na Liu, Yi-Ling Luo, Yifan Zhao, Yu Zhang, Tian-Liang Xia, Shang-Xin Liu, Qi Liu, Guan-Nan Wang, Rui You, Jing-Yun Peng, Jiang Li, Feng Han, Jianwei Wang, Qiu-Yan Chen, Li Zhang, Hai-Qiang Mai, Benjamin E. Gewurz, Bo Zhao, Lawrence S. Young, Qian Zhong, Fan Bai, Mu-Sheng Zeng
https://doi.org/10.1038/s41422-020-00402-8
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Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy

Mengze Lv, Meixia Chen, Rui Zhang, Wen Zhang, Chenguang Wang, Yan Zhang, Xiaoming Wei, Yukun Guan, Jiejie Liu, Kaichao Feng, Miao Jing, Xurui Wang, Yun-Cai Liu, Qian Mei, Weidong Han, Zhengfan Jiang
https://doi.org/10.1038/s41422-020-00395-4
Full Text | PDF | Abstract | Open Access

Kinetics and mechanisms of mitotic inheritance of DNA methylation and their roles in aging-associated methylome deterioration

Xuan Ming, Zhuqiang Zhang, Zhuoning Zou, Cong Lv, Qiang Dong, Qixiang He, Yangyang Yi, Yingfeng Li, Hailin Wang, Bing Zhu
https://doi.org/10.1038/s41422-020-0359-9
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High-resolution mapping of mitotic DNA synthesis regions and common fragile sites in the human genome through direct sequencing

Morgane Macheret, Rahul Bhowmick, Katarzyna Sobkowiak, Laura Padayachy, Jonathan Mailler, Ian D. Hickson, Thanos D. Halazonetis
https://doi.org/10.1038/s41422-020-0358-x
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Genome-wide high-resolution mapping of mitotic DNA synthesis sites and common fragile sites by direct sequencing

Fang Ji, Hongwei Liao, Sheng Pan, Liujian Ouyang, Fang Jia, Zaiyang Fu, Fengjiao Zhang, Xinwei Geng, Xinming Wang, Tingting Li, Shuangying Liu, Madiha Zahra Syeda, Haixia Chen, Wen Li, Zhihua Chen, Huahao Shen, Songmin Ying
https://doi.org/10.1038/s41422-020-0357-y
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Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma

Yu-Pei Chen, Jian-Hua Yin, Wen-Fei Li, Han-Jie Li, Dong-Ping Chen, Cui-Juan Zhang, Jia-Wei Lv, Ya-Qin Wang, Xiao-Min Li, Jun-Yan Li, Pan-Pan Zhang, Ying-Qin Li, Qing-Mei He, Xiao-Jing Yang, Yuan Lei, Ling-Long Tang, Guan-Qun Zhou, Yan-Ping Mao, Chen Wei, Ke-Xu Xiong, Hong-Bo Zhang, Shi-Da Zhu, Yong Hou, Ying Sun, Michael Dean, Ido Amit, Kui Wu, Dong-Ming Kuang, Gui-Bo Li, Na Liu, Jun Ma
https://doi.org/10.1038/s41422-020-0374-x
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LETTERS TO THE EDITOR

25-Hydroxycholesterol is a potent SARS-CoV-2 inhibitor

Shulong Zu, Yong-Qiang Deng, Chao Zhou, Jie Li, Lili Li, Qi Chen, Xiao-Feng Li, Hui Zhao, Sarah Gold, Jun He, Xiang Li, Changqing Zhang, Heng Yang, Genhong Cheng, Cheng-Feng Qin
https://doi.org/10.1038/s41422-020-00398-1
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A mouse model for SARS-CoV-2 infection by exogenous delivery of hACE2 using alphavirus replicon particles

Ya-Nan Zhang, Xiao-Dan Li, Zhe-Rui Zhang, Hong-Qing Zhang, Na Li, Jing Liu, Jia-Qi Li, Hua-Jun Zhang, Ze-Jun Wang, Shuo Shen, Zheng-Li Shi, Hong-Ping Wei, Zhi-Ming Yuan, Han-Qing Ye, Bo Zhang
https://doi.org/10.1038/s41422-020-00405-5
Full Text | PDF | Abstract | Open Access

Cryo-EM structure of the hyperpolarization-activated inwardly rectifying potassium channel KAT1 from Arabidopsis

Siyu Li, Fan Yang, Demeng Sun, Yong Zhang, Mengge Zhang, Sanling Liu, Peng Zhou, Chaowei Shi, Longhua Zhang, Changlin Tian
https://doi.org/10.1038/s41422-020-00407-3
Full Text | PDF | Abstract | Open Access