Advanced Search

Submit Manuscript

Table of Contents

Volume 32 Issue 9, Sep 2022

Nucleosome remodeling of the paternal genome during the first 12 h after fertilization in mice. The knotted ropes represent chromatins in the nucleus. In the first 3 h after fertilization, the protamine (pink knots) on paternal DNA was replaced by histone (yellow knots). Then the nucleosome positioning pattern was continually rebuilt to form nucleosome depletion regions at promoters and transcription factor binding sites, which were represented by more complex knots. See page 801-813 by Chenfei Wang et al. for details.

RESEARCH HIGHLIGHTS

Shaping the sinuses: a novel Krt14+Ctsk+ cell lineage driving regenerative bone formation

Seoyeon Bok, Matthew B. Greenblatt
https://doi.org/10.1038/s41422-022-00694-y
Full Text | PDF | Abstract


Human adult hippocampal neurogenesis is back, again?

Hai-Kun Liu
https://doi.org/10.1038/s41422-022-00698-8
Full Text | PDF | Abstract


R-2-HG assists IDH1-mutant solid tumors by promoting angiogenesis

Nuray Bögürcü-Seidel, Gabriele Bergers
https://doi.org/10.1038/s41422-022-00708-9
Full Text | PDF | Abstract


Efficient replication of human nuclear DNA

Thomas A. Kunkel
https://doi.org/10.1038/s41422-022-00690-2
Full Text | PDF | Abstract


Treatment for giant congenital nevi moves a step closer

Joanna Pozniak, Jean-Christophe Marine
https://doi.org/10.1038/s41422-022-00691-1
Full Text | PDF | Abstract


ORIGINAL ARTICLES

Dynamic nucleosome organization after fertilization reveals regulatory factors for mouse zygotic genome activation

Chenfei Wang, Chuan Chen, Xiaoyu Liu, Chong Li, Qiu Wu, Xiaolan Chen, Lingyue Yang, Xiaochen Kou, Yanhong Zhao, Hong Wang, Yawei Gao, Yong Zhang, Shaorong Gao
https://doi.org/10.1038/s41422-022-00652-8
Full Text | PDF | Abstract | Open Access


A novel lineage of osteoprogenitor cells with dual epithelial and mesenchymal properties govern maxillofacial bone homeostasis and regeneration after MSFL

Yuteng Weng, Haicheng Wang, Di Wu, Shuyu Xu, Xiaofan Chen, Jie Huang, Yanhuizhi Feng, Lin Li, Zuolin Wang
https://doi.org/10.1038/s41422-022-00687-x
Full Text | PDF | Abstract | Open Access


Hetero-bivalent nanobodies provide broad-spectrum protection against SARS-CoV-2 variants of concern including Omicron

Huan Ma, Xinghai Zhang, Peiyi Zheng, Peter H. Dube, Weihong Zeng, Shaohong Chen, Qingyu Cheng, Yunru Yang, Yan Wu, Junhui Zhou, Xiaowen Hu, Yan Xiang, Huajun Zhang, Sandra Chiu, Tengchuan Jin
https://doi.org/10.1038/s41422-022-00700-3
Full Text | PDF | Abstract | Open Access


Glutamate drives ‘local Ca2+ release’ in cardiac pacemaker cells

Duanyang Xie, Ke Xiong, Xuling Su, Guanghua Wang, Qicheng Zou, Luxin Wang, Caihong Zhang, Yuting Cao, Beihua Shao, Yixin Zhang, Peidong Zhang, Dandan Liang, Yi Liu, Yi-Han Chen
https://doi.org/10.1038/s41422-022-00693-z
Full Text | PDF | Abstract | Open Access


LETTERS TO THE EDITOR

Structural insights into ligand binding and activation of the human thyrotropin-releasing hormone receptor

Youwei Xu, Hongmin Cai, Chongzhao You, Xinheng He, Qingning Yuan, Hualiang Jiang, Xi Cheng, Yi Jiang, H. Eric Xu
https://doi.org/10.1038/s41422-022-00641-x
Full Text | PDF | Abstract


Structural insights into thyrotropin-releasing hormone receptor activation by an endogenous peptide agonist or its orally administered analogue

Fan Yang, Huanhuan Zhang, Xianyu Meng, Yingge Li, Yingxin Zhou, Shenglong Ling, Demeng Sun, Pei Lv, Lei Liu, Pan Shi, Changlin Tian
https://doi.org/10.1038/s41422-022-00646-6
Full Text | PDF | Abstract | Open Access


A broadly neutralizing antibody against SARS-CoV-2 Omicron variant infection exhibiting a novel trimer dimer conformation in spike protein binding

Yingdan Wang, Wuqiang Zhan, Jiangyan Liu, Yanqun Wang, Xiang Zhang, Meng Zhang, Lin Han, Yunping Ma, Lu Lu, Yumei Wen, Zhenguo Chen, Jincun Zhao, Fan Wu, Lei Sun, Jinghe Huang
https://doi.org/10.1038/s41422-022-00684-0
Full Text | PDF | Abstract


CORRIGENDA

Author Correction: Formative pluripotent stem cells show features of epiblast cells poised for gastrulation

Xiaoxiao Wang, Yunlong Xiang, Yang Yu, Ran Wang, Yu Zhang, Qianhua Xu, Hao Sun, Zhen-Ao Zhao, Xiangxiang Jiang, Xiaoqing Wang, Xukun Lu, Dandan Qin, Yujun Quan, Jiaqi Zhang, Ng Shyh-Chang, Hongmei Wang, Naihe Jing, Wei Xie, Lei Li
https://doi.org/10.1038/s41422-022-00695-x
Full Text | PDF | Abstract | Open Access