RESEARCH HIGHLIGHTS

Producing hybrid seeds like conventional rice

Hong Yu, Jiayang Li
https://doi.org/10.1038/s41422-022-00733-8
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Promoting T and NK cell attack: preserving tumor MICA/B by vaccines

Frank Cichocki, Jeffrey S. Miller
https://doi.org/10.1038/s41422-022-00696-w
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Run! White blood cells cued by a motor brain under stress

Hai Qi, Bo Liu
https://doi.org/10.1038/s41422-022-00704-z
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Cofactor-assisted dicing: insights from structural snapshots

Jiamu Du, Dinshaw J. Patel
https://doi.org/10.1038/s41422-022-00716-9
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Fine-tuning T cell function through engineered orthogonal chimeric cytokine receptors

Rigel J. Kishton, Nicholas P. Restifo
https://doi.org/10.1038/s41422-022-00715-w
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ORIGINAL ARTICLES

CRISPR FISHer enables high-sensitivity imaging of nonrepetitive DNA in living cells through phase separation-mediated signal amplification

Xin-Yuan Lyu, Yuan Deng, Xiao-Yan Huang, Zhen-Zhen Li, Guo-Qing Fang, Dong Yang, Feng-Liu Wang, Wang Kang, En-Zhi Shen, Chun-Qing Song
https://doi.org/10.1038/s41422-022-00712-z
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Cryo-EM structures of human m6A writer complexes

Shichen Su, Shanshan Li, Ting Deng, Minsong Gao, Yue Yin, Baixing Wu, Chao Peng, Jianzhao Liu, Jinbiao Ma, Kaiming Zhang
https://doi.org/10.1038/s41422-022-00725-8
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Genetically modified CD7-targeting allogeneic CAR-T cell therapy with enhanced efficacy for relapsed/refractory CD7-positive hematological malignancies: a phase I clinical study

Yongxian Hu, Yali Zhou, Mingming Zhang, Houli Zhao, Guoqing Wei, Wengang Ge, Qu Cui, Qitian Mu, Gong Chen, Lu Han, Tingting Guo, Jiazhen Cui, Xiaoyan Jiang, Xiujun Zheng, Shuhui Yu, Xiaolong Li, Xingwang Zhang, Mingxi Chen, Xiuju Li, Ming Gao, Kang Wang, Cheng Zu, Hao Zhang, Xiaohong He, Yanbin Wang, Dongrui Wang, Jiangtao Ren, He Huang
https://doi.org/10.1038/s41422-022-00721-y
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Single-cell epigenome analysis reveals age-associated decay of heterochromatin domains in excitatory neurons in the mouse brain

Yanxiao Zhang, Maria Luisa Amaral, Chenxu Zhu, Steven Francis Grieco, Xiaomeng Hou, Lin Lin, Justin Buchanan, Liqi Tong, Sebastian Preissl, Xiangmin Xu, Bing Ren
https://doi.org/10.1038/s41422-022-00719-6
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LETTERS TO THE EDITOR

mRNA vaccines expressing homo-prototype/Omicron and hetero-chimeric RBD-dimers against SARS-CoV-2

Yuxuan Han, Yaling An, Qian Chen, Kun Xu, Xueyuan Liu, Senyu Xu, Huixin Duan, Annette B. Vogel, Uğur Şahin, Qihui Wang, Lianpan Dai, George F. Gao
https://doi.org/10.1038/s41422-022-00720-z
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Creation of artificial karyotypes in mice reveals robustness of genome organization

Xiaoyu Merlin Zhang, Meng Yan, Zhenhua Yang, Hao Xiang, Wei Tang, Xindong Cai, Qigui Wu, Xin Liu, Gang Pei, Jinsong Li
https://doi.org/10.1038/s41422-022-00722-x
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piRNA 3′ uridylation facilitates the assembly of MIWI/piRNA complex for efficient target regulation in mouse male germ cells

Mao-Zhou Zhao, Di-Hang Lin, Heng Zuo, Huan Wei, Xin Wang, Lan-Tao Gou, Mo-Fang Liu
https://doi.org/10.1038/s41422-022-00659-1
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