Cell Research

Volume 32 Issue 12, Dec 2022

A proteogenomic study reclassified pituitary neuroendocrine tumors into seven subtypes. Each subtype has specific potential treatment targets, which is summarized as the tree in the image. This new, treatment-oriented classification represents a breakthrough for selecting appropriate therapeutic interventions for this highly heterogeneous disease. See page 1047–1067 by Fan Zhang et al. for details.

EDITORIAL

Sanofi-Cell Research outstanding paper award of 2021

https://doi.org/10.1038/s41422-022-00749-0
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RESEARCH HIGHLIGHTS

Off-the-shelf CAR T cells to treat cancer

Sofia Castelli, Regina M. Young, Carl H. June
https://doi.org/10.1038/s41422-022-00745-4
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Sustaining plant immunity in rising temperature

Jian Hua, Xinnian Dong
https://doi.org/10.1038/s41422-022-00710-1
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The scent of a microbe: how host viral infection increases mosquito attraction

Tamia A. Harris-Tryon
https://doi.org/10.1038/s41422-022-00717-8
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Live cold to grow old? Thermogenesis to fight cancer

Henning T. Langer, Lewis C. Cantley, Marcus D. Goncalves
https://doi.org/10.1038/s41422-022-00723-w
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A type III-E CRISPR Craspase exhibiting RNase and protease activities

Hui Yang, Dinshaw J. Patel
https://doi.org/10.1038/s41422-022-00739-2
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ORIGINAL ARTICLES

Integrated proteogenomic characterization across major histological types of pituitary neuroendocrine tumors

Fan Zhang, Qilin Zhang, Jiajun Zhu, Boyuan Yao, Chi Ma, Nidan Qiao, Shiman He, Zhao Ye, Yunzhi Wang, Rui Han, Jinwen Feng, Yongfei Wang, Zhaoyu Qin, Zengyi Ma, Kai Li, Yichao Zhang, Sha Tian, Zhengyuan Chen, Subei Tan, Yue Wu, Peng Ran, Ye Wang, Chen Ding, Yao Zhao
https://doi.org/10.1038/s41422-022-00736-5
Full Text | PDF | Abstract | Open Access

A variant-proof SARS-CoV-2 vaccine targeting HR1 domain in S2 subunit of spike protein

Wei Pang, Ying Lu, Yan-Bo Zhao, Fan Shen, Chang-Fa Fan, Qian Wang, Wen-Qiang He, Xiao-Yan He, Ze-Kai Li, Tao-Tao Chen, Cui-Xian Yang, You-Zhi Li, Si-Xuan Xiao, Zu-Jiang Zhao, Xu-Sheng Huang, Rong-Hua Luo, Liu-Meng Yang, Mi Zhang, Xing-Qi Dong, Ming-Hua Li, Xiao-Li Feng, Qing-Cui Zhou, Wang Qu, Shibo Jiang, Songying Ouyang, Yong-Tang Zheng
https://doi.org/10.1038/s41422-022-00746-3
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Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity

Ying Gao, Xueping Zheng, Boyang Chang, Yujie Lin, Xiaodan Huang, Wen Wang, Shirong Ding, Weixiang Zhan, Shang Wang, Beibei Xiao, Lanqing Huo, Youhui Yu, Yilin Chen, Run Gong, Yuanzhong Wu, Ruhua Zhang, Li Zhong, Xin Wang, Qiuyan Chen, Song Gao, Zhengfan Jiang, Denghui Wei, Tiebang Kang
https://doi.org/10.1038/s41422-022-00731-w
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Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia

Cheng-Long Hu, Bing-Yi Chen, Zijuan Li, Tianbiao Yang, Chun-Hui Xu, Ruirui Yang, Peng-Cheng Yu, Jingyao Zhao, Ting Liu, Na Liu, Bin Shan, Qunling Zhang, Junhong Song, Ming-Yue Fei, Li-Juan Zong, Jia-Ying Zhang, Ji-Chuan Wu, Shu-Bei Chen, Yong Wang, Binhe Chang, Dan Hou, Ping Liu, Yilun Jiang, Xiya Li, Xinchi Chen, Chu-Han Deng, Yi-Yi Ren, Roujia Wang, Jiacheng Jin, Kai Xue, Ying Zhang, Meirong Du, Jun Shi, Ling-Yun Wu, Chun-Kang Chang, Shuhong Shen, Zhu Chen, Sai-Juan Chen, Xiaolong Liu, Xiao-Jian Sun, Mingyue Zheng, Lan Wang
https://doi.org/10.1038/s41422-022-00735-6
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LETTERS TO THE EDITOR

AI-empowered integrative structural characterization of m6A methyltransferase complex

Xuhui Yan, Kai Pei, Zeyuan Guan, Feiqing Liu, Junjun Yan, Xiaohuan Jin, Qiang Wang, Mengjun Hou, Chun Tang, Ping Yin
https://doi.org/10.1038/s41422-022-00741-8
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Cryo-EM structure of the type III-E CRISPR-Cas effector gRAMP in complex with TPR-CHAT

Shuo Wang, Minghui Guo, Yuwei Zhu, Zhiying Lin, Zhiwei Huang
https://doi.org/10.1038/s41422-022-00738-3
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CORRIGENDA

Author Correction: Gut microbiota drives macrophage-dependent self-renewal of intestinal stem cells via niche enteric serotonergic neurons

Pingping Zhu, Tiankun Lu, Jiayi Wu, Dongdong Fan, Benyu Liu, Xiaoxiao Zhu, Hui Guo, Ying Du, Feng Liu, Yong Tian, Zusen Fan
https://doi.org/10.1038/s41422-022-00734-7
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Correction: CRISPR FISHer enables high-sensitivity imaging of nonrepetitive DNA in living cells through phase separation-mediated signal amplification

Xin-Yuan Lyu, Yuan Deng, Xiao-Yan Huang, Zhen-Zhen Li, Guo-Qing Fang, Dong Yang, Feng-Liu Wang, Wang Kang, En-Zhi Shen, Chun-Qing Song
https://doi.org/10.1038/s41422-022-00742-7
Full Text | PDF | Abstract | Open Access