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Volume 34 Issue 8, Aug 2024

The image depicts the legendary Chinese weapon ‘FangTian Ji’, a formidable combination of a spearhead and two crescent blades. This symbolizes the powerful bacterial two-component anti-phage defense system DUF4297–HerA. DUF4297 and HerA cooperatively assemble to activate their respective nuclease and ATPase activities, effectively eliminating invading phages. See page 545–555 by Qiyin An et al. for details.

RESEARCH HIGHLIGHTS

ANT2: the first mammalian mitochondrial RNA transport translocon

Huanhuan Zhu, Weiqiang Lin, Aifu Lin
https://doi.org/10.1038/s41422-024-00994-5
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Z-DNA marks the spot for AIRE

Yael Goldfarb, Jakub Abramson
https://doi.org/10.1038/s41422-024-00964-x
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Novel insight into atrioventricular node conduction


https://doi.org/10.1038/s41422-024-00996-3
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Prometheus 2.0: drug-induced liver regeneration arising

Jan S. Tchorz
https://doi.org/10.1038/s41422-024-00965-w
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ONE-GO: Direct detection of context-dependent GPCR activity

Aleksey Raskovalov, Donggyun Kim, Vadim Cherezov
https://doi.org/10.1038/s41422-024-00966-9
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ORIGINAL ARTICLES

Molecular and structural basis of an ATPase-nuclease dual-enzyme anti-phage defense complex

Qiyin An, Yong Wang, Zhenhua Tian, Jie Han, Jinyue Li, Fumeng Liao, Feiyang Yu, Haiyan Zhao, Yancheng Wen, Heng Zhang, Zengqin Deng
https://doi.org/10.1038/s41422-024-00981-w
Full Text | PDF | Abstract | Open Access


A GABAergic system in atrioventricular node pacemaker cells controls electrical conduction between the atria and ventricles

Dandan Liang, Liping Zhou, Huixing Zhou, Fulei Zhang, Guojian Fang, Junwei Leng, Yahan Wu, Yuemei Zhang, Anqi Yang, Yi Liu, Yi-Han Chen
https://doi.org/10.1038/s41422-024-00980-x
Full Text | PDF | Abstract | Open Access


Localized, highly efficient secretion of signaling proteins by migrasomes

Haifeng Jiao, Xiaopeng Li, Ying Li, Yuting Guo, Xiaoyu Hu, Takami Sho, Yiqun Luo, Jinyu Wang, Huizhen Cao, Wanqing Du, Dong Li, Li Yu
https://doi.org/10.1038/s41422-024-00992-7
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LETTERS TO THE EDITOR

Structural snapshots of human VMAT2 reveal insights into substrate recognition and proton coupling mechanism

Di Wu, Zhuoya Yu, Qihao Chen, Jun Zhao, Bo Huang, Yuhang Wang, Jiawei Su, Na Li, Daohua Jiang, Yan Zhao
https://doi.org/10.1038/s41422-024-00974-9
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Molecular activation and G protein coupling selectivity of human succinate receptor SUCR1

Tianxin Wang, Wenqin Tang, Xiaolei Zhu, Zhenyu Lv, Jiayan Chen, Yongze Li, Xiaoyu Sun, Haoyu Lv, Quanchang Gu, Fahui Li, Jiangyun Wang
https://doi.org/10.1038/s41422-024-00968-7
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Molecular basis of ligand recognition and activation of the human succinate receptor SUCR1

Changyao Li, Heng Liu, Jingru Li, Xinheng He, Haoran Zhu, Wei Fu, H. Eric Xu
https://doi.org/10.1038/s41422-024-00984-7
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