Cell Research

Volume 35 Issue 9, Sep 2025

The colorectal anatomy diagram in the background explains the research background of colorectal cancer in this article. The main image is a flower representing the CiPDO culture system, in which a little girl is nurtured, symbolizing the Oncofetal State and reflecting the plasticity of tumors. See page 642–655 by Liang Xiong et al. for details.

RESEARCH HIGHLIGHTS

Bridging the gap: how sperm’s core structure explains male infertility

Thibault Legal, Khanh Huy Bui
https://doi.org/10.1038/s41422-025-01150-3
Full Text | PDF | Abstract

Neutrophil maturation holds the secret to human tumor suppression

Bianca Calí, Andrea Alimonti
https://doi.org/10.1038/s41422-025-01160-1
Full Text | PDF | Abstract

The night shift: norepinephrine drives glymphatics

Benjamin A. Plog, Leon C. D. Smyth, Jonathan Kipnis
https://doi.org/10.1038/s41422-025-01106-7
Full Text | PDF | Abstract

Gasdermin D pores hitch a ride: extracellular vesicles spread pyroptosis

Gang Du, Hao Wu
https://doi.org/10.1038/s41422-025-01109-4
Full Text | PDF | Abstract

Phase separation paints Xi with Xist

Thomas C. T. Michaels, Anton Wutz
https://doi.org/10.1038/s41422-025-01116-5
Full Text | PDF | Abstract

Meeting Reports?

Organelle biology: emerging themes and future directions

Shulin Li, Liang Ge
https://doi.org/10.1038/s41422-025-01147-y
Full Text | PDF | Abstract

REVIEW ARTICLE

A decade of migrasome research: biogenesis, physiological functions, and disease implications

Jinqiang Yu, Li Yu
https://doi.org/10.1038/s41422-025-01153-0
Full Text | PDF | Abstract | Open Access

ORIGINAL ARTICLES

A patient-derived organoid model captures fetal-like plasticity in colorectal cancer

Liang Xiong, Ying Xu, Zhaoya Gao, Jingyi Shi, Yunfan Wang, Xiaodong Wang, Wensheng Huang, Ming Li, Longteng Wang, Jun Xu, Cheng Li, Jin Gu, Hongkui Deng, Molong Qu
https://doi.org/10.1038/s41422-025-01139-y
Full Text | PDF | Abstract

Disturbed engram network caused by NPTX downregulation underlies aging-related contextual fear memory deficits

Tao Jin, Yang Yang, Yu Guo, Yi Zhang, Qiumin Le, Nan Huang, Xing Liu, Jintai Yu, Lan Ma, Feifei Wang
https://doi.org/10.1038/s41422-025-01157-w
Full Text | PDF | Abstract | Open Access

Deubiquitinase-dependent transcriptional silencing controls inflammation

Yuxin Yi, Wenjie Xu, Pengcheng Mi, Siliang Ye, Li Chen, Neal M. Alto, Zixu Liu
https://doi.org/10.1038/s41422-025-01140-5
Full Text | PDF | Abstract

LETTERS TO THE EDITOR

Differentiation therapy with hepatocyte nuclear factor 4α for patients with hepatocellular carcinoma

Chuan Yin, Wen-Ping Xu, Wei-Hua Dong, Chen-Hong Ding, Jia-Rong Cai, Xin Zeng, Si-Han Wu, Pei-Mei Shi, Xin Zhang, Wei-Fen Xie
https://doi.org/10.1038/s41422-025-01142-3
Full Text | PDF | Abstract | Open Access

Modeling mammalian hibernation to improve organ cold preservation: Using the intestine as an example

Weiya He, Ziqing He, Wenjun Deng, Chuman Wu, Wenjie Huang, Changhui Li, Yan Liang, Yifu Chen, Renjie Luo, Yifei Zhao, Jiayu Liao, Xin Zhou, Guokai Chen, Ren-He Xu, Meiling Liu, Ji Dong
https://doi.org/10.1038/s41422-025-01149-w
Full Text | PDF | Abstract