EDITORIAL

Escaping ageing through Cell Annealing—a phenomenological model

Sebastian Memczak, Juan Carlos Izpisua Belmonte, Thore Graepel
https://doi.org/10.1038/s41422-025-01138-z
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RESEARCH HIGHLIGHTS

SPO11 cuts!

Sara Hariri, Neil Hunter
https://doi.org/10.1038/s41422-025-01093-9
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Beyond housekeeping: a new role of snoRNA in nascent protein secretion

Hao Wu, Chu-Xiao Liu, Ling-Ling Chen
https://doi.org/10.1038/s41422-024-01070-8
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Killing cancer quickly: inducing hyper-acute rejection of patient tumors

Eric Bartee
https://doi.org/10.1038/s41422-025-01099-3
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New insights into how parental worms protect their offspring

Chenming Zeng, Eric A. Miska
https://doi.org/10.1038/s41422-025-01094-8
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Neoself-antigen presentation in SLE: Mordred’s coronation in Arthur’s absence

Mehrdad Pazhouhandeh, Hongjian Sun, Di Yu
https://doi.org/10.1038/s41422-024-01052-w
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Mimicking the TCR immune synapse for improved CAR-T cell function

Tom Enbar, Li Tang
https://doi.org/10.1038/s41422-025-01086-8
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ORIGINAL ARTICLES

In situ structure of the mouse sperm central apparatus reveals mechanistic insights into asthenozoospermia

Yun Zhu, Tingting Lin, , Linhua Tai, Lianwan Chen, Jing Ma, Guoning Huang, Yi Lu, Zhiyong Zhang, Binbin Wang, Suren Chen, Fei Sun
https://doi.org/10.1038/s41422-025-01135-2
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DNA remnants in red blood cells enable early detection of cancer

Haobo Sun, Xingyun Yao, Yurong Jiao, Xiangxing Kong, Yuehua Han, Ying Li, Jianping Ge, Yanfei Cao, Hongsheng Lu, Pingli Wang, Yu Xu, Jun Li, Kefeng Ding, Xiaofei Gao
https://doi.org/10.1038/s41422-025-01122-7
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Human myelocyte and metamyelocyte-stage neutrophils suppress tumor immunity and promote cancer progression

Wei Liu, Tao Shi, Chun Lu, Keying Che, Zijian Zhang, Yuting Luo, Daniel Hirschhorn, Hanbing Wang, Shaorui Liu, Yan Wang, Shuang Liu, Haiqiao Sun, Jun Lu, Yuan Liu, Dongquan Shi, Shuai Ding, Heping Xu, Liaoxun Lu, Jianming Xu, Jun Xin, Yinming Liang, Taha Merghoub, Jia Wei, Yan Li
https://doi.org/10.1038/s41422-025-01145-0
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LETTERS TO THE EDITOR

Allogeneic anti-CD19 CAR-T cells induce remission in refractory systemic lupus erythematosus

Chunmei Yang, Chuanyin Sun, Binghe Tan, Chao Hu, Liyan Wan, Chris Wang, Xiujuan Shi, Juliang Qin, Na Zhang, Biao Zheng, Mingyao Liu, Jin Lin, Bing Du, Hongyan Tong
https://doi.org/10.1038/s41422-025-01128-1
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Phrixotoxin-3 binds to three distinct antagonistic sites on human Na_v1.6

Xiao Fan, Jiaofeng Chen, Xiaoshuang Huang, Zhanfeng Hou, Yuzhen Xie, Zigang Li, Nieng Yan, Jian Huang
https://doi.org/10.1038/s41422-025-01141-4
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Editorial Expression of Concern

Editorial Expression of Concern: p53’s mitochondrial translocation and MOMP action is independent of Puma and Bax and severely disrupts mitochondrial membrane integrity

Sonja Wolff, Susan Erster, Gustavo Palacios, Ute M Moll
https://doi.org/10.1038/s41422-025-01129-0
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CORRIGENDA

Author Correction: SPSB1-mediated HnRNP A1 ubiquitylation regulates alternative splicing and cell migration in EGF signaling

Feng Wang, Xing Fu, Peng Chen, Ping Wu, Xiaojuan Fan, Na Li, Hong Zhu, Ting-Ting Jia, Hongbin Ji, Zefeng Wang, Catherine C L Wong, Ronggui Hu, Jingyi Hui
https://doi.org/10.1038/s41422-025-01132-5
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