RESEARCH HIGHLIGHTS

Mitochondria target the plasma membrane to cause mitoxyperiosis

Jaiya Randhawa, Luke A. J. O’Neill
https://doi.org/10.1038/s41422-025-01215-3
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AXIS of excitability: microglia promote neuronal firing

Victoria L. Palfini, Matthew N. Rasband
https://doi.org/10.1038/s41422-026-01237-5
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Lysosomal magneto-mechanics rewire immunity

Seyed Hossein Helalat, Marja Jäättelä
https://doi.org/10.1038/s41422-026-01236-6
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To β or not to β: think zinc (again)!

Omar Zabad, Kathrin Maedler
https://doi.org/10.1038/s41422-026-01238-4
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PERSPECTIVE

Transcriptomic advances in studies of muscle stem cell aging: From bulk to single-cell and beyond

Soochi Kim, Seung Pil Pack, Thomas A. Rando
https://doi.org/10.1038/s41422-026-01240-w
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ORIGINAL ARTICLES

Mitochondrial double-stranded RNA drives aging-associated cognitive decline

Lixiao Zhang, Xiang Li, Hongdi Luo, Yujia Huo, Guangkeng Zhou, Pengcheng Wang, Sipeng Wu, Xinyong Lin, Kai Dai, Jiahao Shi, Zebao Wang, Jiaxin Xu, Renjian Li, Siyi Chen, Zhe Sun, Chunlin Zhao, Zizhuo Zhou, Zhenhong Wang, Chensi Liang, Jun Zhu, Xingjun Chen, Jintao Luo, Yong Yu, Zhirong Zhang, Geng Wang
https://doi.org/10.1038/s41422-026-01224-w
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Sensing of DNA double-strand breaks by the NHEJ system stabilizes RORγt transcriptional activity and shapes Th17 pathogenicity in autoimmunity

Guan-Yu Chen, Wen-Jie Zhu, Zhuang Li, Yun-Wei Hu, Xiao-Shuang Luo, Zhi-Qing Mai, Yuan Pan, Yu-Xun Shi, Zuo-Yi Li, Jun Huang, Pei-Dong Yuan, Zhi-Qiang Xiao, Qian Chen, Yan-Yan Xie, Hai-Xiang Huang, Yu-Xi Chen, Yao Lu, Min-Zhen Wang, Yi-Wen Xia, Xiao-Qing Chen, Dong-Ming Kuang, Dan Liang
https://doi.org/10.1038/s41422-025-01204-6
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Zinc accumulation-induced integrated stress response triggers β-cell identity loss

Qing Ma, Wenjun Xu, Xuan Wang, Haoyu Nie, Yukun Gao, Rui Hu, Zhihao Yang, Xushu Wang, Ta Na, Xiangyi Chen, Zhaoyue Wang, Minglu Xu, Li Shao, Meng Guo, Yanfang Liu, Rongrong Le, Shaorong Gao, Weida Li
https://doi.org/10.1038/s41422-026-01222-y
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LETTERS TO THE EDITOR

IRES–cargo interplay structurally modulates circular RNA translation

Youkui Huang, Yao-Qi Chen, Si-Yu Lou, Xiang Gao, Yu-Xin Liu, Yu-Lu Zhang, Fang Nan, Ling-Ling Chen, Li Yang
https://doi.org/10.1038/s41422-026-01233-9
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Chemical reprogramming directly resets mouse post-implantation epiblast cells to a totipotent state

Hai Zhou, Xuzhao Zhai, Chikai Zhou, Junyu Chen, Xiukun Wang, Ling Li, Wenwen Shi, Shu Sun, Guokai Chen, Guang Hu, Erwei Zuo, Man Zhang
https://doi.org/10.1038/s41422-026-01244-6
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