Volume 35, No 9, Sep 2025

ISSN: 1001-0602 
EISSN: 1748-7838  
2020 impact factor 25.617*  
(Clarivate Analytics, 2021)

About the cover

The colorectal anatomy diagram in the background explains the research background of colorectal cancer in this article. The main image is a flower representing the CiPDO culture system, in which a little girl is nurtured, symbolizing the Oncofetal State and reflecting the plasticity of tumors. See page 642–655 by Liang Xiong et al. for details.

Advanced Online Publication: 3 Sep 2025

ORIGINAL ARTICLES

Targeting necrotic lipid release in tumors enhances immunosurveillance and cancer immunotherapy of glioblastoma

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Current Issue: Vol.35 (Sep 2025)

RESEARCH HIGHLIGHTS

Bridging the gap: how sperm’s core structure explains male infertility
Neutrophil maturation holds the secret to human tumor suppression
The night shift: norepinephrine drives glymphatics
Gasdermin D pores hitch a ride: extracellular vesicles spread pyroptosis
Phase separation paints Xi with Xist

Meeting Reports?

Organelle biology: emerging themes and future directions

REVIEW ARTICLE

A decade of migrasome research: biogenesis, physiological functions, and disease implications

ORIGINAL ARTICLES

A patient-derived organoid model captures fetal-like plasticity in colorectal cancer
Disturbed engram network caused by NPTX downregulation underlies aging-related contextual fear memory deficits
Deubiquitinase-dependent transcriptional silencing controls inflammation

LETTERS TO THE EDITOR

Differentiation therapy with hepatocyte nuclear factor 4α for patients with hepatocellular carcinoma
Modeling mammalian hibernation to improve organ cold preservation: Using the intestine as an example