Volume 35, No 10, Oct 2025

ISSN: 1001-0602 
EISSN: 1748-7838  
2020 impact factor 25.617*  
(Clarivate Analytics, 2021)

About the cover

The thatched cottage symbolizes the gastruloid formed by human gastrulating stem cells. Its development surges forward like a river. The trees on the bank, the lotus flowers and leaves drifting on the water, and the distant mountains together signify the development of organs arising from the three germ layers within the gastruloid. See page 719–734 by Mingqian Huang et al. for details.

Advanced Online Publication: 2 Oct 2025

ORIGINAL ARTICLES

Secondary structure transitions and dual PIP2 binding define cardiac KCNQ1-KCNE1 channel gating

Read more

Current Issue: Vol.35 (Oct 2025)

RESEARCH HIGHLIGHTS

Cultured human stem cells undergoing gastrulation
Osteocalcin has many tricks to get γ-carboxylated
Novel organoid culture condition: modeling fetal-like plasticity in colorectal cancer
SIX of one and half-a-dozen USP2 regulating inflammation
Beyond peptide targeting sequences: machine learning of cellular condensate localization
A phytoalexin dismantles bacterial type III injectisome

REVIEW ARTICLE

Lung cell fates during influenza

ORIGINAL ARTICLES

Establishment of human gastrulating stem cells with the capacity of stable differentiation into multiple gastrulating cell types
Structural insights into the vitamin K-dependent γ-carboxylation of osteocalcin
AlphaCD: a machine learning model capable of highly accurate characterization for 21,335 cytidine deaminases
Autism-related proteins form a complex to maintain the striatal asymmetry in mice

LETTERS TO THE EDITOR

Structure and activation mechanism of human sweet taste receptor

CORRIGENDA

Author Correction: Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4