Volume 35, No 11, Nov 2025

ISSN: 1001-0602 
EISSN: 1748-7838  
2020 impact factor 25.617*  
(Clarivate Analytics, 2021)

About the cover

A single chopstick cannot pick up food, just as an individual TLR3 molecule cannot efficiently initiate innate immune activation on its own. Rmrp acts as the coordinating element that brings two TLR3 molecules together into a functional dimer, much like a hand uniting two chopsticks for coordinated action. See page 824–839 by Shikun Zhang et al. for details

Advanced Online Publication: 7 Nov 2025

ORIGINAL ARTICLES

The molecular basis of μ-opioid receptor signaling plasticity

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Current Issue: Vol.35 (Nov 2025)

RESEARCH HIGHLIGHTS

Self-RNA Rmrp pre-dimerizes TLR3 for immune activation
Deconstructing the architecture of memory engrams
LGP2 stops MDA5 translocation to start antiviral signaling
Niche-generated taurine is leukemic fuel
Why resident microglial-like cells were missed in the peripheral nervous system
Selective CDK4 inhibition holds promise for breast cancer

REVIEW ARTICLE

Trained immunity: induction of an inflammatory memory in disease
Lineage plasticity and histological transformation: tumor histology as a spectrum

ORIGINAL ARTICLES

Molecular characterization of endosomal self RNA Rmrp-engaged TLR3 dimerization to prime innate activation
Soluble tissue factor generated by necroptosis-triggered shedding is responsible for thrombosis
Targeting necrotic lipid release in tumors enhances immunosurveillance and cancer immunotherapy of glioblastoma
Mechanisms of KCNQ1 gating modulation by KCNE1/3 for cell-specific function
Secondary structure transitions and dual PIP2 binding define cardiac KCNQ1-KCNE1 channel gating
ATP-dependent one-dimensional movement maintains immune homeostasis by suppressing spontaneous MDA5 filament assembly

LETTERS TO THE EDITOR

Constitutive arrestin recruitment by orphan GPR52 via an atypical binding mode
Molecular basis of vitamin K-dependent protein γ-glutamyl carboxylation