RESEARCH HIGHLIGHTS

mTORC1 maintains metabolic balance

Heesun Cheong and Daniel J Klionsky
10.1038/cr.2015.107
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How phosphoubiquitin activates Parkin E3 activity

Xinde Zheng1 and Tony Hunter
10.1038/cr.2015.97
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RNA Pol II as a sensor of 5caC

Jian-Huang Xue and Guo-Liang Xu
10.1038/cr.2015.103
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Cutting in on a secretase pas de deux

Michael S Wolfe
10.1038/cr.2015.106
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ORIGINAL ARTICLES

G protein-coupled receptor 183 facilitates endothelial-to-hematopoietic transition via Notch1 inhibition

Panpan Zhang, Qiuping He, Dongbo Chen, Weixiao Liu, Lu Wang, Chunxia Zhang, Dongyuan Ma, Wei Li, Bing Liu and Feng Liu
10.1038/cr.2015.109
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Dynamic tubulation of mitochondria drives mitochondrial network formation

Chong Wang, Wanqing Du, Qian Peter Su, Mingli Zhu, Peiyuan Feng, Ying Li, Yichen Zhou, Na Mi, Yueyao Zhu, Dong Jiang, Senyan Zhang, Zerui Zhang, Yujie Sun and Li Yu
10.1038/cr.2015.89
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Siglec1 suppresses antiviral innate immune response by inducing TBK1 degradation via the ubiquitin ligase TRIM27

Qingliang Zheng, Jin Hou, Ye Zhou, Yingyun Yang, Bing Xie and Xuetao Cao
10.1038/cr.2015.108
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Acute inflammation stimulates a regenerative response in the neonatal mouse heart

Chunyong Han, Yu Nie, Hong Lian, Rui Liu, Feng He, Huihui Huang and Shengshou Hu
10.1038/cr.2015.110
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Ci antagonizes Hippo signaling in the somatic cells of the ovary to drive germline stem cell differentiation

Chaoyi Li, Lijuan Kan, Yan Chen, Xiudeng Zheng, Weini Li, Wenxin Zhang, Lei Cao, Xiaohui Lin, Shanming Ji, Shoujun Huang, Guoqiang Zhang, Xiaohui Liu, Yi Tao, Shian Wu and Dahua Chen
10.1038/cr.2015.114
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LETTERS TO THE EDITOR

Bromodeoxyuridine promotes full-chemical induction of mouse pluripotent stem cells

Yuan Long, Min Wang, Haifeng Gu and Xin Xie
10.1038/cr.2015.96
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YAP activates the Hippo pathway in a negative feedback loop

Xiaoming Dai, Huan Liu, Shuying Shen, Xiaocan Guo, Huan Yan, Xinyan Ji, Li Li, Jun Huang, Xin-Hua Feng and Bin Zhao
10.1038/cr.2015.101
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