RESEARCH HIGHLIGHTS

Antiviral immunity: a link to bile acids

Jing Wang , Richard A. Flavel and Hua-Bing Li
https://doi.org/10.1038/s41422-019-0148-5
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Degrading proteins in animals: “PROTAC”tion goes in vivo

Jianping Guo , Jing Liu and Wenyi Wei
https://doi.org/10.1038/s41422-019-0144-9
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Divide to conquer: NLRP3 is activated on dispersed trans-Golgi network

Kaiwen W. Chen , Dave Boucher and Petr Broz
https://doi.org/10.1038/s41422-018-0138-z
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ORIGINAL ARTICLES

Structural insights into a high fidelity variant of SpCas9

Minghui Guo , Kuan Ren, Yuwei Zhu, Ziyun Tang, Yuhang Wang, Bailing Zhang and Zhiwei Huang
https://doi.org/10.1038/s41422-018-0131-6
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Virus-induced accumulation of intracellular bile acids activates the TGR5-β-arrestin-SRC axis to enable innate antiviral immunity

Ming-Ming Hu, Wen-Rui He , Peng Gao, Qing Yang , Ke He, Li-Bo Cao, Shu Li, Yu-Qi Feng and Hong-Bing Shu
https://doi.org/10.1038/s41422-018-0136-1
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Hormones induce the formation of luminal-derived basal cells in the mammary gland

Wenqian Song, Ran Wang , Weimin Jiang, Qi Yin, Guangdun Peng, Ruikai Yang , Qing Cissy Yu, Jianfeng Chen, Jingsong Li,Tom H. Cheung, Naihe Jing and Yi Arial Zeng
https://doi.org/10.1038/s41422-018-0137-0
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A programmed wave of uridylation-primed mRNA degradation is essential for meiotic progression and mammalian spermatogenesis

Marcos Morgan , Yuka Kabayama, Christian Much , Ivayla Ivanova, Monica Di Giacomo , Tatsiana Auchynnikava , Jack Michael Monahan , Dimitrios Michael Vitsios , Lina Vasiliauskaitė , Stefano Comazzetto , Juri Rappsilber , Robin Campbell Allshire , Bo Torben Porse , Anton James Enright and Dónal O’Carroll
https://doi.org/10.1038/s41422-018-0128-1
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PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins

Yongjia Duan, Aiying Du , Jinge Gu , Gang Duan , Chen Wang , Xinrui Gui, Zhiwei Ma, Beituo Qian , Xue Deng , Kai Zhang, Le Sun, Kuili Tian, Yaoyang Zhang, Hong Jiang, Cong Liuand Yanshan Fang
https://doi.org/10.1038/s41422-019-0141-z
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LETTERS TO THE EDITOR

TET2 stabilization by 14-3-3 binding to the phosphorylated Serine 99 is deregulated by mutations in cancer

Hao Chen , Dingdang Yu , Rui Fang , Kimberlie Rabidou, Di Wu , Di Hu , Peilin Jia , Zhongming Zhao , Zhiping Wu, Junmin Peng, Yang Shi and Yujiang Geno Shi
https://doi.org/10.1038/s41422-018-0132-5
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Architecture of type VI secretion system membrane core complex

Meng Yin, Zhaofeng Yan and Xueming Li
https://doi.org/10.1038/s41422-018-0130-7
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SENP6-mediated M18BP1 deSUMOylation regulates CENP-A centromeric localization

Hang Fu , Nan Liu, Qiang Dong , Chunxiao Ma , Jing Yang ,Jun Xiong , Zhuqiang Zhang , Xiangbing Qi ,Chang Huangand Bing Zhu
https://doi.org/10.1038/s41422-018-0139-y
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