RESEARCH HIGHLIGHTS

STIM1 is a precise thermo-sensor in skin

Robert M. Nwokonko, Yandong Zhou and Donald L. Gill
https://doi.org/10.1038/s41422-019-0154-7
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Anti-Zika virus RNAi in neural progenitor cells

Xuping Xieand Pei-Yong Shi
https://doi.org/10.1038/s41422-019-0158-3
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Broken hearts: Iron overload, ferroptosis and cardiomyopathy

Marcus Conrad and Bettina Proneth
https://doi.org/10.1038/s41422-019-0150-y
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ORIGINAL ARTICLES

Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids

Yan-Peng Xu , Yang Qiu , Boya Zhang , Guilai Chen, Qi Chen, Miao Wang , Fan Mo , Jiuyue Xu, Jin Wu , Rong-Rong Zhang, Meng-Li Cheng, Na-Na Zhang, Bao Lyu , Wen-Liang Zhu, Meng-Hua Wu, Qing Ye, Da Zhang, Jiang-Hong Man, Xiao-Feng Li , Jie Cui, Zhiheng Xu , Baoyang Hu , Xi Zhou and Cheng-Feng Qin
https://doi.org/10.1038/s41422-019-0152-9
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Structures of the human spliceosomes before and after release of the ligated exon

Xiaofeng Zhang , Xiechao Zhan, Chuangye Yan , Wenyu Zhang, Dongliang Liu , Jianlin Lei and Yigong Shi
https://doi.org/10.1038/s41422-019-0143-x
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LncRNAs-directed PTEN enzymatic switch governs epithelial–mesenchymal transition

Qingsong Hu , Chunlai Li, Shouyu Wang, Yajuan Li , Bo Wen 3,4, Yanyan Zhang 1,10, Ke Liang , Jun Yao, Youqiong Ye , Heidi Hsiao, Tina K. Nguyen , Peter K. Park, Sergey D. Egranov , David H. Hawke , Jeffrey R. Marks, Leng Han , Mien-Chie Hung, Bing Zhang, Chunru Lin and Liuqing Yang

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Coupling of ssRNA cleavage with DNase activity in type III-A CRISPR-Csm revealed by cryo-EM and biochemistry

Minghui Guo, Kaiming Zhang, Yuwei Zhu, Grigore D. Pintilie , Xiaoyu Guan , Shanshan Li , Michael F. Schmid , Zhuo Ma, Wah Chiu and Zhiwei Huang
https://doi.org/10.1038/s41422-019-0151-x
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Vitamin B12 modulates Parkinson’s disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection

Adam Schaffner , Xianting Li , Yacob Gomez-Llorente, Emmanouela Leandrou , Anna Memou, Nicolina Clemente, Chen Yao ,Farinaz Afsari , Lianteng Zhi , Nina Pan , Keita Morohashi , Xiaoluan Hua , Ming-Ming Zhou, Chunyu Wang, Hui Zhang,Shu G. Chen, Christopher J. Elliott, Hardy Rideout, Iban Ubarretxena-Belandia and Zhenyu Yue
https://doi.org/10.1038/s41422-019-0153-8
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LETTERS TO THE EDITOR

Structural basis of the crosstalk between histone H2B monoubiquitination and H3 lysine 79 methylation on nucleosome

Tonghui Yao, Wei Jing, Zhiguo Hu , Ming Tan, Mi Cao ,Qianmin Wang, Yan Li , Guiyong Yuan , Ming Lei and Jing Huang
https://doi.org/10.1038/s41422-019-0146-7
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CRISPR/Cas9-mediated PINK1 deletion leads to neurodegeneration in rhesus monkeys

Weili Yang, Yunbo Liu, Zhuchi Tu , Chong Xiao , Sen Yan,Xishan Ma, Xiangyu Guo, Xiusheng Chen , Peng Yin , Zhengyi Yang, Su Yang, Tianzi Jiang , Shihua Li sup>3and Xiao-Jiang Li
https://doi.org/10.1038/s41422-019-0142-y
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CORRIGENDA

Author Correction: Gene and mutation independent therapy via CRISPR-Cas9 mediated cellular reprogramming in rod photoreceptors

Jie Zhu , Chang Ming , Xin Fu , Yaou Duan, Duc Anh Hoang , Jeffrey Rutgard , Runze Zhang , Wenqiu Wang, Rui Hou ,Daniel Zhang, Edward Zhang , Charlotte ZhangEye Gene Therapy Consortium, Xiaoke Hao, Wenjun Xiong and Kang Zhang
https://doi.org/10.1038/s41422-019-0140-0
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Author Correction: Hormones induce the formation of luminal-derived basal cells in the mammary gland

Wenqian Song, Ran Wang , Weimin Jiang, Qi Yin, Guangdun Peng, Ruikai Yang , Qing Cissy Yu, Jianfeng Chen, Jingsong Li,Tom H. Cheung, Naihe Jing and Yi Arial Zeng
https://doi.org/10.1038/s41422-019-0147-6
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