RESEARCH HIGHLIGHTS

pH-sensitive anti-CTLA4 antibodies: yes to efficacy, no to toxicity

Amnon Altman and Kok-Fai Kong

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Microbiota guides insulin trafficking in beta cells

Ozren Stojanović and Mirko Trajkovski
https://doi.org/10.1038/s41422-019-0200-5
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Crystallizing BubR1’s kinase activity

Jazeel F. Limzerwalaand Jan M. van Deursen
https://doi.org/10.1038/s41422-019-0199-7
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AIF: an acquired metabolic liability in lung cancer

Brandon Faubert, Ralph J. DeBerardinis and John D. Minna
https://doi.org/10.1038/s41422-019-0197-9
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ORIGINAL ARTICLES

Hijacking antibody-induced CTLA-4 lysosomal degradation for safer and more effective cancer immunotherapy

Yan Zhang, Xuexiang Du, Mingyue Liu, Fei Tang, Peng Zhang, Chunxia Ai, James K. Fields, Eric J. Sundberg ,Olga S. Latinovic , Martin Devenport , Pan Zheng and Yang Liu
https://doi.org/10.1038/s41422-019-0184-1
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Intragenic antagonistic roles of protein and circRNA in tumorigenesis

Jlenia Guarnerio, Yang Zhang, Giulia Cheloni, Riccardo Panella, Jesse Mae Katon, Mark Simpson, Akinobu Matsumoto,Antonella Papa, Cristian Loretelli, Andreas Petri, Sakari Kauppinen, Cassandra Garbutt, Gunnlaugur Petur Nielsen,Vikram Deshpande, Mireia Castillo-Martin, Carlos Cordon-Cardo, Spentzos Dimitrios, John G. Clohessy, Mona Batish and Pier Paolo Pandolfi
https://doi.org/10.1038/s41422-019-0192-1
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Interferon-inducible cytoplasmic lncLrrc55-AS promotes antiviral innate responses by strengthening IRF3 phosphorylation

Yumei Zhou, Mengxuan Li, Yiquan Xue, Zhiqing Li, Weitao Wen, Xingguang Liu, Yuanwu Ma, Lianfeng Zhang, Zhongyang Shen and Xuetao Cao
https://doi.org/10.1038/s41422-019-0193-0
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Structural basis of allosteric regulation of Tel1/ATM kinase

Jiyu Xin, Zhu Xu, Xuejuan Wang , Yanhua Tian, Zhihui Zhang and Gang Cai
https://doi.org/10.1038/s41422-019-0176-1
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NDP52 tunes cortical actin interaction with astral microtubules for accurate spindle orientation

Huijuan Yu, Fengrui Yang , Peng Dong, Shanhui Liao, Wei R. Liu, Gangyin Zhao , Bo Qin , Zhen Dou , Zhe Liu, Wei Liu,Jianye Zang , Jennifer Lippincott-Schwartz, Xing Liu and Xuebiao Yao

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LETTERS TO THE EDITOR

Structure of the mannose transporter of the bacterial phosphotransferase system

Xueli Liu, Jianwei Zeng, Kai Huang1 and Jiawei Wang
https://doi.org/10.1038/s41422-019-0194-z
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Structural insights into the activation of ATM kinase

Jianxiong Xiao , Mengjie Liu , Yilun Qi, Yuriy Chaban,Chao Gao, Beiqing Pan, Yuan Tian, Zishuo Yu, Jie Li,Peijun Zhang and Yanhui Xu
https://doi.org/10.1038/s41422-019-0205-0
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