RESEARCH HIGHLIGHTS

Towards precise, safe genome editing

Sebastian Memczak , Yanjiao Shao and Juan Carlos Izpisua Belmonte
https://doi.org/10.1038/s41422-019-0188-x
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Lnc(ing) interferon production and action

Ganes C. Sen and Bryan R. G. Williams
https://doi.org/10.1038/s41422-019-0207-y
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Interferon-γ induces cancer cell ferroptosis

Laurence Zitvogel and Guido Kroemer
https://doi.org/10.1038/s41422-019-0186-z
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Histone lysine de-β-hydroxybutyrylation by SIRT3

Susan M. Abmayr and Jerry L. Workman 1
https://doi.org/10.1038/s41422-019-0211-2
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ORIGINAL ARTICLES

A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts

Bingqing Xie , Da Sun , Yuanyuan Du, Jun Jia, Shicheng Sun, Jun Xu1, Yifang Liu, Chengang Xiang, Sitong Chen,Huangfan Xie , Qiming Wang, Guangya Li, Xuehui LYU, Hui Shen, Shiyu Li, Min Wu, Xiaonan Zhang, Yue Pu, Kuanhui Xiang,Weifeng Lai, Peng Du, Zhenghong Yuan, Cheng Li, Yan Shi1, Shichun Lu and Hongkui Deng
https://doi.org/10.1038/s41422-019-0196-x
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Coagulation factors VII, IX and X are effective antibacterial proteins against drug-resistant Gram-negative bacteria

Jinwu Chen, Xiaojie Li, Ling Li , Ting Zhang, Qing Zhang, Fangming Wu, Diyue Wang, Hongze Hu, Changlin Tian ,Dongsheng Liao, Liang Zhao, Danxia Song, Yongyun Zhao, Chuanfang Wuand Xu Song
https://doi.org/10.1038/s41422-019-0202-3
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Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma

Junya Peng, Bao-Fa Sun , Chuan-Yuan Chen , Jia-Yi Zhou , Yu-Sheng Chen, Hao Chen, Lulu Liu, Dan Huang, Jialin Jiang,Guan-Shen Cui , Ying Yang , Wenze Wang, Dan Guo, Menghua Dai, Junchao Guo, Taiping Zhang, Quan Liao, Yi Liu,Yong-Liang Zhao, Da-Li Han , Yupei Zhao , Yun-Gui Yang and Wenming Wu
https://doi.org/10.1038/s41422-019-0195-y
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A cyclic nucleotide-gated channel mediates cytoplasmic calcium elevation and disease resistance in rice

Jiachang Wang, Xi Liu, An Zhang, Yulong Ren, Fuqing Wu, Gang Wang, Yang Xu, Cailin Lei, Shanshan Zhu, Tian Pan, Yongfei Wang, Huan Zhang, Fan Wang, Yan-Qiu Tan, Yupeng Wang, Xin Jin, Sheng Luo, Chunlei Zhou, Xiao Zhang, Jinling Liu,Shuai Wang, Lingzhi Meng, Yihua Wang, Xi Chen, Qibing Lin, Xin Zhang, Xiuping Guo, Zhijun Cheng, Jiulin Wang, Yunlu Tian, Shijia Liu, Ling Jiang, Chuanyin Wu, Ertao Wang, Jian-Min Zhou , Yong-Fei Wang, Haiyang Wang and Jianmin Wan
https://doi.org/10.1038/s41422-019-0219-7
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NDUFAB1 confers cardio-protection by enhancing mitochondrial bioenergetics through coordination of respiratory complex and supercomplex assembly

Tingting Hou, Rufeng Zhang, Chongshu Jian, Wanqiu Ding, Yanru Wang, Shukuan Ling, Qi Ma, Xinli Hu, Heping Chengand Xianhua Wang
https://doi.org/10.1038/s41422-019-0208-x
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LETTERS TO THE EDITOR

Multivalent m6A motifs promote phase separation of YTHDF proteins

Yifei Gao , Gaofeng Pei , Dongxue Li , Ru Li, Yanqiu Shao , Qiangfeng Cliff Zhang and Pilong Li
https://doi.org/10.1038/s41422-019-0210-3
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Forkhead domain mutations in FOXA1 drive prostate cancer progression

Shuai Gao, Sujun Chen , Dong Han, David Barret, Wanting Han, Musaddeque Ahmed, Susan Patalano, Jill A. Macoska, Housheng Hansen He and Changmeng Cai
https://doi.org/10.1038/s41422-019-0203-2
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Altered chromatin recruitment by FOXA1 mutations promotes androgen independence and prostate cancer progression

Bohan Xu, Bing Song, Xiaodong Lu, Jung Kim, Ming H, Jonathan C. Zhao and Jindan Yu
https://doi.org/10.1038/s41422-019-0204-1
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CORRIGENDA

Author Correction: Threshold for neural tube defect risk by accumulated singleton loss-of-function variants

Zhongzhong Chen , Yunping Lei , Yufang Zheng,Vanessa Aguiar-Pulido , M. Elizabeth Ross , Rui Peng , Li Jin ,Ting Zhang, Richard H. Finnell and Hongyan Wang
https://doi.org/10.1038/s41422-019-0201-4
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Author Correction: Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma

Junya Peng, Bao-Fa Sun , Chuan-Yuan Chen , Jia-Yi Zhou, Yu-Sheng Chen , Hao Chen, Lulu Liu, Dan Huang, Jialin Jiang,Guan-Shen Cui , Ying Yang , Wenze Wang, Dan Guo , Menghua Dai, Junchao Guo, Taiping Zhang, Quan Liao, Yi Liu, Yong-Liang Zhao, Da-Li Han , Yupei Zhao , Yun-Gui Yang and Wenming Wu
https://doi.org/10.1038/s41422-019-0212-1
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Publisher Correction: Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis

Shanhui Liao , Girish Rajendraprasad , Na Wang, Susana Eibes, Jun Gao, Huijuan Yu, Gao Wu, Xiaoming Tu, Hongda Huang,Marin Barisic and Chao Xu
https://doi.org/10.1038/s41422-019-0215-y
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