Cell Research

Volume 29 Issue 10, Oct 2019

‘Nuwa mends the sky’ is a traditional Chinese myth where the goddess Nuwa smelted five colored-stones to patch up the sky and save all mankind. This story reflects how GV-971, a marine derived oligosaccharide, fills in the gap in the current Alzheimer's treatment via targeting a gut-brain axis. See page 787-803 by Xinyi Wang et al. for details.

RESEARCH HIGHLIGHTS

The microbiome: A target for Alzheimer disease?

Dong-oh Seo, Benjamin D. Boros and David M. Holtzman
https://doi.org/10.1038/s41422-019-0227-7
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De-fusing mitochondria defuses the mtDNA time-bomb

Patrick F. Chinnery and Julien Prudent
https://doi.org/10.1038/s41422-019-0206-z
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Mutagenic replication: target for tumor therapy?

Jacob G. Jansen and Niels de Wind
https://doi.org/10.1038/s41422-019-0218-8
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Cool(ing) brain stem GABA neurons

Ramón A. Piñoland Marc L. Reitman
https://doi.org/10.1038/s41422-019-0223-y
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ORIGINAL ARTICLES

Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression

Xinyi Wang, Guangqiang Sun, Teng Feng, Jing Zhang, Xun Huang, Tao Wang, Zuoquan Xie, Xingkun Chu, Jun Yang,Huan Wang, Shuaishuai Chang, Yanxue Gong, Lingfei Ruan, Guanqun Zhang, Siyuan Ya, Wen Lian, Chen Du, Dabing Yang,Qingli Zhang, Feifei Lin, Jia Liu, Haiyan Zhang, Changrong Ge, Shifu Xiao, Jian Ding2 and Meiyu Geng2
https://doi.org/10.1038/s41422-019-0216-x
Full Text | PDF | Abstract | Open Access

Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction

Keiichiro Suzuki , Mako Yamamoto , Reyna Hernandez-Benitez, Zhe Li , Christopher Wei, Rupa Devi Soligalla, Emi Aizawa , Fumiyuki Hatanaka, Masakazu Kurita , Pradeep Reddy, Alejandro Ocampo, Tomoaki Hishida, Masahiro Sakurai ,Amy N. Nemeth, Estrella Nuñez Delicado, Josep M. Campistol, Pierre Magistretti, Pedro Guillen, Concepcion Rodriguez Esteban,Jianhui Gong , Yilin Yuan , Ying Gu , Guang-Hui Liu , Carlos López-Otín, Jun Wu, Kun Zhang and Juan Carlos Izpisua Belmonte
https://doi.org/10.1038/s41422-019-0213-0
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A cyclic nucleotide-gated channel mediates cytoplasmic calcium elevation and disease resistance in rice

Jiachang Wang , Xi Liu, An Zhang, Yulong Ren, Fuqing Wu, Gang Wang, Yang Xu, Cailin Lei, Shanshan Zhu, Tian Pan,Yongfei Wang, Huan Zhang, Fan Wang, Yan-Qiu Tan, Yupeng Wang, Xin Jin, Sheng Luo, Chunlei Zhou, Xiao Zhang, Jinling Liu,Shuai Wang, Lingzhi Meng, Yihua Wang, Xi Chen, Qibing Lin, Xin Zhang, Xiuping Guo, Zhijun Cheng, Jiulin Wang, Yunlu Tian,Shijia Liu, Ling Jiang, Chuanyin Wu, Ertao Wang, Jian-Min Zhou , Yong-Fei Wang , Haiyang Wang and Jianmin Wan
https://doi.org/10.1038/s41422-019-0219-7
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Protein C receptor is a therapeutic stem cell target in a distinct group of breast cancers

Daisong Wang, Xin Hu2, Chunye Liu, Yingying Jia, Yiqin Bai, Cheguo Cai, Jingqiang Wang, Lanyue Bai, Ruikai Yang,ChangDong Lin, Yi-Rong Liu, Shan Li, Feng Qiao, Ling Yao, Li Chen, Gaoxiang Ge, Hai Jiang , Dianfan Li, Lin Li ,JianFeng Chen, Zhi-Ming Shao and Yi Arial Zeng
https://doi.org/10.1038/s41422-019-0225-9
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Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade

Nicolas Jacquelot , Takahiro Yamazaki, Maria P. Roberti , Connie P. M. Duong , Miles C. Andrews ,Loic Verlingue , Gladys Ferrere, Sonia Becharef , Marie Vétizou, Romain Daillère , Meriem Messaoudene, David P. Enot , Gautier Stoll , Stefano Ugel, Ilaria Marigo, Shin Foong Ngiow , Aurélien Marabelle , Armelle Prevost-Blondel , Pierre-Olivier Gaudreau, Vancheswaran Gopalakrishnan, Alexander M. Eggermont, Paule Opolon,Christophe Klein, Gabriele Madonna, Paolo A. Ascierto , Antje Sucker, Dirk Schadendorf , Mark J. Smyth ,Jean-Charles Soria , Guido Kroemer , Vincenzo Bronte, Jennifer Wargo and Laurence Zitvogel
https://doi.org/10.1038/s41422-019-0224-x
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LETTERS TO THE EDITOR

Optogenetic gene editing in regional skin

Fei Li , Zhiwei Lu , Wenbo Wu , Nannan Qian,Fengchao Wang and Ting Chen
https://doi.org/10.1038/s41422-019-0209-9
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Maternal exposure to triclosan constitutes a yet unrecognized risk factor for autism spectrum disorders

Zijian Hao, Qionghui Wu, Zhengwei Li, Yali Li, Qiu Li, Xi Lai,Huan Liu, Menghuan Zhang, Ting Yang, Jie Chen,Yaping Tang , Jingkun Miao, Huatai Xu, Tingyu Li and Ronggui Hu
https://doi.org/10.1038/s41422-019-0220-1
Full Text | PDF | Abstract | Open Access