Cell Research

Volume 31 Issue 8, Aug 2021

SARS-CoV-2 envelope protein (2-E) attacks host cells offensively via forming a type of cation channels on biological membranes. The newly identified channel blocker BE-33 exhibits excellent anti-viral activity in mice infection model. 2-E channel is a promising drug target against SARS-CoV-2.See page 847-860 by Bingqing Xia et al. for details.

RESEARCH HIGHLIGHTS

SARS-CoV-2 vaccines: anamnestic response in previously infected recipients

Jyothi N. Purushotham, Neeltje van Doremalen, Vincent J. Munster
https://doi.org/10.1038/s41422-021-00516-7
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Nascent RNA m6A modification at the heart of the gene–retrotransposon conflict

Victor Billon, Gael Cristofari
https://doi.org/10.1038/s41422-021-00518-5
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Host genetics, the microbiome & behaviour—a ‘Holobiont’ perspective

Jatin Nagpal, John F. Cryan
https://doi.org/10.1038/s41422-021-00512-x
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Pancreatic endocrinogenesis revisited: “I have all the answers, who has the questions?”

Willem Staels, Raphael Scharfmann
https://doi.org/10.1038/s41422-021-00489-7
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ORIGINAL ARTICLES

A cohort autopsy study defines COVID-19 systemic pathogenesis

Xiao-Hong Yao, Tao Luo, Yu Shi, Zhi-Cheng He, Rui Tang, Pei-Pei Zhang, Jun Cai, Xiang-Dong Zhou, Dong-Po Jiang, Xiao-Chun Fei, Xue-Quan Huang, Lei Zhao, Heng Zhang, Hai-Bo Wu, Yong Ren, Zhen-Hua Liu, Hua-Rong Zhang, Cong Chen, Wen-Juan Fu, Heng Li, Xin-Yi Xia, Rong Chen, Yan Wang, Xin-Dong Liu, Chang-Lin Yin, Ze-Xuan Yan, Juan Wang, Rui Jing, Tai-Sheng Li, Wei-Qin Li, Chao-Fu Wang, Yan-Qing Ding, Qing Mao, Ding-Yu Zhang, Shu-Yang Zhang, Yi-Fang Ping, Xiu-Wu Bian
https://doi.org/10.1038/s41422-021-00523-8
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SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target

Bingqing Xia, Xurui Shen, Yang He, Xiaoyan Pan, Feng-Liang Liu, Yi Wang, Feipu Yang, Sui Fang, Yan Wu, Zilei Duan, Xiaoli Zuo, Zhuqing Xie, Xiangrui Jiang, Ling Xu, Hao Chi, Shuangqu Li, Qian Meng, Hu Zhou, Yubo Zhou, Xi Cheng, Xiaoming Xin, Lin Jin, Hai-Lin Zhang, Dan-Dan Yu, Ming-Hua Li, Xiao-Li Feng, Jiekai Chen, Hualiang Jiang, Gengfu Xiao, Yong-Tang Zheng, Lei-Ke Zhang, Jingshan Shen, Jia Li, Zhaobing Gao
https://doi.org/10.1038/s41422-021-00519-4
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RNA m6A modification orchestrates a LINE-1–host interaction that facilitates retrotransposition and contributes to long gene vulnerability

Feng Xiong, Ruoyu Wang, Joo-Hyung Lee, Shenglan Li, Shin-Fu Chen, Zian Liao, Lana Al Hasani, Phuoc T. Nguyen, Xiaoyu Zhu, Joanna Krakowiak, Dung-Fang Lee, Leng Han, Kuang-Lei Tsai, Ying Liu, Wenbo Li
https://doi.org/10.1038/s41422-021-00515-8
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Sequential progenitor states mark the generation of pancreatic endocrine lineages in mice and humans

Xin-Xin Yu, Wei-Lin Qiu, Liu Yang, Yan-Chun Wang, Mao-Yang He, Dan Wang, Yu Zhang, Lin-Chen Li, Jing Zhang, Yi Wang, Cheng-Ran Xu
https://doi.org/10.1038/s41422-021-00486-w
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Single-cell transcriptomic analysis of somatosensory neurons uncovers temporal development of neuropathic pain

Kaikai Wang, Sashuang Wang, Yan Chen, Dan Wu, Xinyu Hu, Yingjin Lu, Liping Wang, Lan Bao, Changlin Li, Xu Zhang
https://doi.org/10.1038/s41422-021-00479-9
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Association of assisted reproductive technology, germline de novo mutations and congenital heart defects in a prospective birth cohort study

Cheng Wang, Hong Lv, Xiufeng Ling, Hong L, Feiyang Diao, Juncheng Dai1, Jiangbo Du, Ting Chen, Qi Xi, Yang Zhao, Kun Zhou, Bo Xu, Xiumei Han, Xiaoyu Liu, Meijuan Peng, Congcong Chen, Shiyao Tao, Lei Huang, Cong Liu, Mingyang Wen, Yangqian Jiang, Tao Jiang, Chuncheng Lu, Wei Wu, Di Wu, Minjian Chen, Yuan Lin, Xuejiang Guo, Ran Huo, Jiayin Liu, Hongxia Ma, Guangfu Jin, Yankai Xia, Jiahao Sha, Hongbing Shen, Zhibin Hu
https://doi.org/10.1038/s41422-021-00521-w
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LETTERS TO THE EDITOR

Molecular basis of ligand recognition and activation of human V2 vasopressin receptor

Fulai Zhou, Chenyu Ye, Xiaomin Ma, Wanchao Yin, Tristan I. Croll, Qingtong Zhou, Xinheng He, Xiaokang Zhang, Dehua Yang, Peiyi Wang, H. Eric Xu, Ming-Wei Wang, Yi Jiang
https://doi.org/10.1038/s41422-021-00480-2
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Cryo-EM structure of the AVP–vasopressin receptor 2–Gs signaling complex

Lei Wang, Jun Xu, Sheng Cao, Dapeng Sun, Heng Liu, Qiuyuan Lu, Zheng Liu, Yang Du, Cheng Zhang
https://doi.org/10.1038/s41422-021-00483-z
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Sulfated glycosaminoglycans and low-density lipoprotein receptor mediate the cellular entry of Clostridium novyi alpha-toxin

Yao Zhou, Diyin Li, Jianhua Luo, Aizhong Chen, Xingxing Li, Zhenrui Pan, Li Wan, Liuqing He, Danyang Li, Yanyan Li, Min Dong, Liang Tao
https://doi.org/10.1038/s41422-021-00510-z
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CORRIGENDA

Publisher Correction: Single-cell transcriptomic analysis of somatosensory neurons uncovers temporal development of neuropathic pain

Kaikai Wang, Sashuang Wang, Yan Chen, Dan Wu, Xinyu Hu, Yingjin Lu, Liping Wang, Lan Bao, Changlin Li, Xu Zhang
https://doi.org/10.1038/s41422-021-00503-y
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