RESEARCH HIGHLIGHTS

Finding a new job: glutamate signaling acts in atrial cardiomyocytes

Svetlana Reilly, Stanley Nattel
https://doi.org/10.1038/s41422-021-00513-w
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Beyond targeted protein degradation: LD·ATTECs clear cellular lipid droplets

Elena De Vita, Daniel Lucy, Edward W. Tate
https://doi.org/10.1038/s41422-021-00546-1
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Heart defects recapitulated in human cardioids

Valeria V. Orlova, Christine L. Mummery
https://doi.org/10.1038/s41422-021-00534-5
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Somatic mutation accumulation seen through a single-molecule lens

Lovelace J. Luquette, Peter J. Park
https://doi.org/10.1038/s41422-021-00537-2
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ORIGINAL ARTICLES

Identification of an endogenous glutamatergic transmitter system controlling excitability and conductivity of atrial cardiomyocytes

Duanyang Xie, Ke Xiong, Xuling Su, Guanghua Wang, Qiang Ji, Qicheng Zou, Lingling Wang, Yi Liu, Dandan Liang, Jinfeng Xue, Luxin Wang, Xueting Gao, Xingdong Gu, Hongyu Liu, Xiaoyu He, Li Li, Jian Yang, Youming Lu, Luying Peng, Yi-Han Chen
https://doi.org/10.1038/s41422-021-00499-5
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Degradation of lipid droplets by chimeric autophagy-tethering compounds

Yuhua Fu, Ningxie Chen, Ziying Wang, Shouqing Luo, Yu Ding, Boxun Lu
https://doi.org/10.1038/s41422-021-00532-7
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The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8

Jia-yuan Zhang, Bo Zhou, Ru-yue Sun, Yuan-li Ai, Kang Cheng, Fu-nan Li, Bao-rui Wang, Fan-jian Liu, Zhi-hong Jiang, Wei-jia Wang, Dawang Zhou, Hang-zi Chen, Qiao Wu
https://doi.org/10.1038/s41422-021-00506-9
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Endogenous reverse transcriptase and RNase H-mediated antiviral mechanism in embryonic stem cells

Junyu Wu, Chunyan Wu, Fan Xing, Liu Cao, Weijie Zeng, Liping Guo, Ping Li, Yongheng Zhong, Hualian Jiang, Manhui Luo, Guang Shi, Lang Bu, Yanxi Ji, Panpan Hou, Hong Peng, Junjiu Huang, Chunmei Li, Deyin Guo
https://doi.org/10.1038/s41422-021-00524-7
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Interferon-armed RBD dimer enhances the immunogenicity of RBD for sterilizing immunity against SARS-CoV-2

Shiyu Sun, Yueqi Cai, Tian-Zhang Song, Yang Pu, Lin Cheng, Hairong Xu, Jing Sun, Chaoyang Meng, Yifan Lin, Haibin Huang, Fang Zhao, Silin Zhang, Yu Gao, Jian-Bao Han, Xiao-Li Feng, Dan-Dan Yu, Yalan Zhu, Pu Gao, Haidong Tang, Jincun Zhao, Zheng Zhang, Jiaming Yang, Zhenxiang Hu, Yang-Xin Fu, Yong-Tang Zheng, Hua Peng
https://doi.org/10.1038/s41422-021-00531-8
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LETTERS TO THE EDITOR

Hsp70 chaperones TDP-43 in dynamic, liquid-like phase and prevents it from amyloid aggregation

Jinge Gu, Chen Wang, Rirong Hu, Yichen Li, Shengnan Zhang, Yunpeng Sun, Qiangqiang Wang, Dan Li, Yanshan Fang, Cong Liu
https://doi.org/10.1038/s41422-021-00526-5
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Pharmacological inhibition of SRC-1 phase separation suppresses YAP oncogenic transcription activity

Guangya Zhu, Jingjing Xie, Zhenzhen Fu, Mingliang Wang, Qichen Zhang, Hao He, Zijun Chen, Xin Guo, Jidong Zhu
https://doi.org/10.1038/s41422-021-00504-x
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A single mutation underlying phenotypic convergence for hypoxia adaptation on the Qinghai-Tibetan Plateau

Dongming Xu, Cuiping Yang, Qiushuo Shen, Shengkai Pan, Zhen Liu, Tongzuo Zhang, Xin Zhou, Menglong Lei, Peng Chen, Hui Yang, Tao Zhang, Yuanting Guo, Xiangjiang Zhan, Yongbin Chen, Peng Shi
https://doi.org/10.1038/s41422-021-00517-6
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Structural basis for recognition of anti-migraine drug lasmiditan by the serotonin receptor 5-HT1F–G protein complex

Sijie Huang, Peiyu Xu, Yangxia Tan, Chongzhao You, Yumu Zhang, Yi Jiang, H. Eric Xu
https://doi.org/10.1038/s41422-021-00527-4
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