RESEARCH HIGHLIGHTS

Neutralizing shapeshifting pericytes enhances glioblastoma therapeutic efficacy

Samuel A. Sprowls, Justin D. Lathia
https://doi.org/10.1038/s41422-021-00538-1
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Building early defenses

Yi Ding, Avinash Bhandoola
https://doi.org/10.1038/s41422-021-00535-4
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Gasdermin B in the host–pathogen tug-of-war

Timurs Maculins, Ivan Dikic
https://doi.org/10.1038/s41422-021-00544-3
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Linear ubiquitin chains break blood vessel branches

Yuri Shibata, David Komande
https://doi.org/10.1038/s41422-021-00553-2
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ORIGINAL ARTICLES

Mechanical activation of spike fosters SARS-CoV-2 viral infection

Wei Hu, Yong Zhang, Panyu Fei, Tongtong Zhang, Danmei Yao, Yufei Gao, Jia Liu, Hui Chen, Qiao Lu, Tenny Mudianto, Xinrui Zhang, Chuxuan Xiao, Yang Ye, Qiming Sun, Jing Zhang, Qi Xie, Pei-Hui Wang, Jun Wang, Zhenhai Li, Jizhong Lou, Wei Chen
https://doi.org/10.1038/s41422-021-00558-x
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Structural mechanism of calcium-mediated hormone recognition and Gβ interaction by the human melanocortin-1 receptor

Shanshan Ma, Yan Chen, Antao Dai, Wanchao Yin, Jia Guo, Dehua Yang, Fulai Zhou, Yi Jiang, Ming-Wei Wang, H. Eric Xu
https://doi.org/10.1038/s41422-021-00557-y
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Pericytes augment glioblastoma cell resistance to temozolomide through CCL5-CCR5 paracrine signaling

Xiao-Ning Zhang, Kai-Di Yang, Cong Chen, Zhi-Cheng He, Qiang-Hu Wang, Hua Feng, Sheng-Qing Lv, Yan Wang, Min Mao, Qing Liu, Yao-Yao Tan, Wen-Ying Wang, Tian-Ran Li, Lin-Rong Che, Zhong-Yi Qin, Ling-Xiang Wu, Min Luo, Chun-Hua Luo, Yu-Qi Liu, Wen Yin, Chao Wang, Hai-Tao Guo, Qing-Rui Li, Bin Wang, Wei Chen, Shuang Wang, Yu Shi, Xiu-Wu Bian, Yi-Fang Ping
https://doi.org/10.1038/s41422-021-00528-3
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A phosphatidic acid-binding lncRNA SNHG9 facilitates LATS1 liquid–liquid phase separation to promote oncogenic YAP signaling

Rui-Hua Li, Tian Tian, Qi-Wei Ge, Xin-Yu He, Cheng-Yu Shi, Jun-Hong Li, Zhen Zhang, Fang-Zhou Liu, Ling-Jie Sang, Zuo-Zhen Yang, Ya-Zhuo Liu, Yan Xiong, Qingfeng Yan, Xu Li, Huai-Qiang Ju, Jian Liu, Liang-Jing Wang, Jian-Zhong Shao, Wenqi Wang, Tianhua Zhou, Aifu Lin
https://doi.org/10.1038/s41422-021-00530-9
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Delineating spatiotemporal and hierarchical development of human fetal innate lymphoid cells

Chen Liu, Yandong Gong, Han Zhang, Hua Yang, Yang Zeng, Zhilei Bian, Qian Xin, Zhijie Bai, Man Zhang, Jian He, Jing Yan, Jie Zhou, Zongcheng Li, Yanli Ni, Aiqing Wen, Yu Lan, Hongbo Hu, Bing Liu
https://doi.org/10.1038/s41422-021-00529-2
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LETTERS TO THE EDITOR

O-glycosylation pattern of the SARS-CoV-2 spike protein reveals an “O-Follow-N” rule

Wenmin Tian, Delin Li, Nan Zhang, Guijie Bai, Kai Yuan, Haixia Xiao, Feng Gao, Yang Chen, Catherine C. L. Wong, George Fu Gao
https://doi.org/10.1038/s41422-021-00545-2
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Structure-based analyses of neutralization antibodies interacting with naturally occurring SARS-CoV-2 RBD variants

Hua Xu, Bo Wang, Tian-Ning Zhao, Zi-Teng Liang, Tian-Bo Peng, Xiao-Hui Song, Jia-Jing Wu, You-Chun Wang, Xiao-Dong Su
https://doi.org/10.1038/s41422-021-00554-1
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Structures of SARS-CoV-2 B.1.351 neutralizing antibodies provide insights into cocktail design against concerning variants

Shuo Du, Pulan Liu, Zhiying Zhang, Tianhe Xiao, Ayijiang Yasimayi, Weijin Huang, Youchun Wang, Yunlong Cao, Xiaoliang Sunney Xie, Junyu Xiao
https://doi.org/10.1038/s41422-021-00555-0
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Enhancing prime editing by Csy4-mediated processing of pegRNA

Yao Liu, Guang Yang, Shuhong Huang, Xiangyang Li, Xin Wang, Guanglei Li, Tian Chi, Yulin Chen, Xingxu Huang, Xiaolong Wang
https://doi.org/10.1038/s41422-021-00520-x
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CORRIGENDA

Author Corrections: VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex

Wenjing Zhang, Yijun Gao, Peixue Li, Zhubing Shi, Tong Guo, Fei Li, Xiangkun Han, Yan Feng, Chao Zheng, Zuoyun Wang, Fuming Li, Haiquan Chen, Zhaocai Zhou, Lei Zhang, Hongbin Ji
https://doi.org/10.1038/s41422-021-00551-4
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Author Correction: miR-486 sustains NF-κB activity by disrupting multiple NF-κB-negative feedback loops

Libing Song, Chuyong Lin, Hui Gong, Chanjuan Wang, Liping Liu, Jueheng Wu, Sha Tao, Bo Hu, Shi-Yuan Cheng, Mengfeng Li, Jun Li
https://doi.org/10.1038/s41422-021-00549-y
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