RESEARCH HIGHLIGHTS

Cuproptosis: a copper-triggered modality of mitochondrial cell death

Daolin Tang, Xin Chen, Guido Kroemer
https://doi.org/10.1038/s41422-022-00653-7
Full Text | PDF | Abstract

Targeting Hv1 proton channel for pain control

Kenta Furutani, Ru-Rong Ji
https://doi.org/10.1038/s41422-022-00648-4
Full Text | PDF | Abstract

Lipid nanoparticle-mRNA: another step in the fight against COVID-19

Abhishek Kumar Verma, Stanley Perlman
https://doi.org/10.1038/s41422-022-00647-5
Full Text | PDF | Abstract

Banking on metabolomics for novel therapies in TNBC

Aurelien Tripp, George Poulogiannis
https://doi.org/10.1038/s41422-022-00637-7
Full Text | PDF | Abstract

ORIGINAL ARTICLES

Evolutionarily conservative and non-conservative regulatory networks during primate interneuron development revealed by single-cell RNA and ATAC sequencing

Ziqi Zhao, Dan Zhang, Fuqiang Yang, Mingrui Xu, Shaoli Zhao, Taotao Pan, Chuanyu Liu, Yongjie Liu, Qingfeng Wu, Qiang Tu, Ping Zhou, Rong Li, Jia Kang, Lan Zhu, Fei Gao, Yaqing Wang, Zhiheng Xu
https://doi.org/10.1038/s41422-022-00635-9
Full Text | PDF | Abstract | Open Access

Near-atomic structure of the inner ring of the Saccharomyces cerevisiae nuclear pore complex

Zongqiang Li, Shuaijiabin Chen, Liang Zhao, Guoqiang Huang, Xiong Pi, Shan Sun, Peiyi Wang, Sen-Fang Sui
https://doi.org/10.1038/s41422-022-00632-y
Full Text | PDF | Abstract | Open Access

Cryo-EM structure of the inner ring from the Xenopus laevis nuclear pore complex

Gaoxingyu Huang, Xiechao Zhan, Chao Zeng, Ke Liang, Xuechen Zhu, Yanyu Zhao, Pan Wang, Qifan Wang, Qiang Zhou, Qinghua Tao, Minhao Liu, Jianlin Lei, Chuangye Yan, Yigong Shi
https://doi.org/10.1038/s41422-022-00633-x
Full Text | PDF | Abstract | Open Access

Inhibiting Hv1 channel in peripheral sensory neurons attenuates chronic inflammatory pain and opioid side effects

Qiansen Zhang, Yimin Ren, Yiqing Mo, Peipei Guo, Ping Liao, Yuncheng Luo, Jie Mu, Zhuo Chen, Yang Zhang, Ya Li, Linghui Yang, Daqing Liao, Jie Fu, Juwen Shen, Wei Huang, Xuewen Xu, Yanyan Guo, Lianghe Mei, Yunxia Zuo, Jin Liu, Huaiyu Yang, Ruotian Jiang
https://doi.org/10.1038/s41422-022-00616-y
Full Text | PDF | Abstract

Comprehensive metabolomics expands precision medicine for triple-negative breast cancer

Yi Xiao, Ding Ma, Yun-Song Yang, Fan Yang, Jia-Han Ding, Yue Gong, Lin Jiang, Li-Ping Ge, Song-Yang Wu, Qiang Yu, Qing Zhang, François Bertucci, Qiuzhuang Sun, Xin Hu, Da-Qiang Li, Zhi-Ming Shao, Yi-Zhou Jiang
https://doi.org/10.1038/s41422-022-00614-0
Full Text | PDF | Abstract | Open Access

LETTERS TO THE EDITOR

Immune escape by SARS-CoV-2 Omicron variant and structural basis of its effective neutralization by a broad neutralizing human antibody VacW-209

Bin Ju, Qingbing Zheng, Huimin Guo, Qing Fan, Tingting Li, Shuo Song, , Hui Sun, Senlin Shen, Xinrong Zhou, Wenhui Xue, Lingyan Cui, Bing Zhou, Shaowei Li, Ningshao Xia, Zheng Zhang
https://doi.org/10.1038/s41422-022-00638-6
Full Text | PDF | Abstract

The P132H mutation in the main protease of Omicron SARS-CoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition

Michael Dominic Sacco, Yanmei Hu, Maura Verenice Gongora, Flora Meilleur, Michael Trent Kemp, Xiujun Zhang, Jun Wang, Yu Chen
https://doi.org/10.1038/s41422-022-00640-y
Full Text | PDF | Abstract

Structures of human bile acid exporter ABCB11 reveal a transport mechanism facilitated by two tandem substrate-binding pockets

Liang Wang, Wen-Tao Hou, Jie Wang, Da Xu, Cong Guo, Linfeng Sun, Ke Ruan, Cong-Zhao Zhou, Yuxing Chen
https://doi.org/10.1038/s41422-021-00611-9
Full Text | PDF | Abstract