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Volume 32 Issue 4, Apr 2022

The theme of face-changing in Beijing Opera reflects the fate conversion of embryonic vascular endothelial cells. Along with the change of face are the colors of costume, fan, waves and fish, alluding to the widespread endothelial fate conversion. Direction of the swimming fish upstream represents a venous-to-arterial fate change as opposed to the direction of blood flow from artery to the vein. See page 333-348 by Siyuan Hou et al. for details. Cover art is contributed by Wenxi Ye.

RESEARCH HIGHLIGHTS

Vein to artery: the first arteriogenesis in the mammalian embryo

Siyeon Rhee, Joseph C. Wu
https://doi.org/10.1038/s41422-022-00629-7
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Revealing the secret behind Smo cholesterylation

Yuhong Han, Jin Jiang
https://doi.org/10.1038/s41422-022-00636-8
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Transcriptomic profiling fuels the derivation of stable pig epiblast stem cells

Cuiqing Zhong, Ronghui Li, Juan Carlos Izpisua Belmonte
https://doi.org/10.1038/s41422-021-00609-3
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Innovative adjuvant augments potency of a SARS-CoV-2 subunit vaccine

Hua Peng, Yang-Xin Fu
https://doi.org/10.1038/s41422-022-00634-w
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ORIGINAL ARTICLES

Heterogeneity in endothelial cells and widespread venous arterialization during early vascular development in mammals

Siyuan Hou, Zongcheng Li, Ji Dong, Yun Gao, Zhilin Chang, Xiaochen Ding, Shuaili Li, Yunqiao Li, Yang Zeng, Qian Xin, Baihan Wang, Yanli Ni, Xiaowei Ning, Yuqiong Hu, Xiaoying Fan, Yu Hou, Xianlong Li, Lu Wen, Bin Zhou, Bing Liu, Fuchou Tang, Yu Lan
https://doi.org/10.1038/s41422-022-00615-z
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Cryo-EM structure of the nuclear ring from Xenopus laevis nuclear pore complex

Gaoxingyu Huang, Xiechao Zhan, Chao Zeng, Xuechen Zhu, Ke Liang, Yanyu Zhao, Pan Wang, Qifan Wang, Qiang Zhou, Qinghua Tao, Minhao Liu, Jianlin Lei, Chuangye Yan, Yigong Shi
https://doi.org/10.1038/s41422-021-00610-w
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EGFR signaling promotes nuclear translocation of plasma membrane protein TSPAN8 to enhance tumor progression via STAT3-mediated transcription

Xiaoqing Lu, Liwei An, Guangjian Fan, Lijuan Zang, Weiyi Huang, Junjian Li, Jun Liu, Weiyu Ge, Yuwei Huang, Jingxuan Xu, Shaoqian Du, Yuan Cao, Tianhao Zhou, Huijing Yin, Li Yu, Shi Jiao, Hongxia Wang
https://doi.org/10.1038/s41422-022-00628-8
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Lipid nanoparticle-encapsulated mRNA antibody provides long-term protection against SARS-CoV-2 in mice and hamsters

Yong-Qiang Deng, Na-Na Zhang, Yi-Fei Zhang, Xia Zhong, Sue Xu, Hong-Ying Qiu, Tie-Cheng Wang, Hui Zhao, Chao Zhou, Shu-Long Zu, Qi Chen, Tian-Shu Cao, Qing Ye, Hang Chi, Xiang-Hui Duan, Dan-Dan Lin, Xiao-Jing Zhang, Liang-Zhi Xie, Yu-Wei Gao, Bo Ying, Cheng-Feng Qin
https://doi.org/10.1038/s41422-022-00630-0
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Generation and characterization of stable pig pregastrulation epiblast stem cell lines

Minglei Zhi, Jinying Zhang, Qianzi Tang, Dawei Yu, Shuai Gao, Dengfeng Gao, Pengliang Liu, Jianxiong Guo, Tang Hai, Jie Gao, Suying Cao, Zimo Zhao, Chongyang Li, Xiaogang Weng, Mengnan He, Tianzhi Chen, Yingjie Wang, Keren Long, Deling Jiao, Guanglei Li, Jiaman Zhang, Yan Liu, Yu Lin, Daxin Pang, Qianqian Zhu, Naixin Chen, Jingjing Huang, Xinze Chen, Yixuan Yao, Jingcang Yang, Zicong Xie, Xianya Huang, Mengxin Liu, Ran Zhang, Qiuyan Li, Yiliang Miao, Jianhui Tian, Bofeng Liu, Wei Xie, Qi Zhou, Hongjiang Wei, Zhonghua Liu, Caihong Zheng, Mingzhou Li, Jianyong Han
https://doi.org/10.1038/s41422-021-00592-9
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LETTERS TO THE EDITOR

Rapid development of an updated mRNA vaccine against the SARS-CoV-2 Omicron variant

Na-Na Zhang, Rong-Rong Zhang, Yi-Fei Zhang, Kai Ji, Xiao-Chuan Xiong, Qian-Shan Qin, Peng Gao, Xi-Shan Lu, Hang-Yu Zhou, Hai-Feng Song, Bo Ying, Cheng-Feng Qin
https://doi.org/10.1038/s41422-022-00626-w
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Peptide-based pan-CoV fusion inhibitors maintain high potency against SARS-CoV-2 Omicron variant

Shuai Xia, Jasper Fuk-Woo Chan, Lijue Wang, Fanke Jiao, Kenn Ka-Heng Chik, Hin Chu, Qiaoshuai Lan, Wei Xu, Qian Wang, Chao Wang, Kwok-Yung Yuen, Lu Lu, Shibo Jiang
https://doi.org/10.1038/s41422-022-00617-x
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Spontaneous necroptosis and autoinflammation are blocked by an inhibitory phosphorylation on MLKL during neonatal development

Xinxin Zhu, Na Yang, Yu Yang, Feiyang Yuan, Dandan Yu, Yu Zhang, Zhaoqian Shu, Ning Nan, Hong Hu, Xiaoyan Liu, She Chen, Liming Sun, Huayi Wang
https://doi.org/10.1038/s41422-021-00583-w
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Structural basis for the gating modulation of Kv4.3 by auxiliary subunits

Demin Ma, Cheng Zhao, Xiaochen Wang, Xiaoxiao Li, Yi Zha, Yan Zhang, Guosheng Fu, Ping Liang, Jiangtao Guo, Dongwu Lai
https://doi.org/10.1038/s41422-021-00608-4
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CORRIGENDA

Author Correction: Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma

Yongping Cui, Hongyan Chen, Ruibin Xi, Heyang Cui, Yahui Zhao, Enwei Xu, Ting Yan, Xiaomei Lu, Furong Huang, Pengzhou Kong, Yang Li, Xiaolin Zhu, Jiawei Wang, Wenjie Zhu, Jie Wang, Yanchun Ma, Yong Zhou, Shiping Guo, Ling Zhang, Yiqian Liu, Bin Wang, Yanfeng Xi, Ruifang Sun, Xiao Yu, Yuanfang Zhai, Fang Wang, Jian Yang, Bin Yang, Caixia Cheng, Jing Liu, Bin Song, Hongyi Li, Yi Wang, Yingchun Zhang, Xiaolong Cheng, Qimin Zhan, Yanhong Li, Zhihua Liu
https://doi.org/10.1038/s41422-022-00625-x
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