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Table of Contents

Volume 33 Issue 2, Feb 2023

A study identified a novel APOE4-specific receptor LilrB3. A butterfly-like Cryo-EM structure of the complex reveals the details of how the immune “checkpoint” receptor LilrB3 recognizes APOE4. Upon binding, it will induce microglia cell into an Alzheimer Disease-associated status. See page 116–130 by Jiayao Zhou et al. for details.

RESEARCH HIGHLIGHTS

A new route for EV biogenesis.

Li Yu
https://doi.org/10.1038/s41422-022-00747-2
Full Text | PDF | Abstract


Illuminating brain development

Courtney A. Burger, Richard A. Lang
https://doi.org/10.1038/s41422-022-00732-9
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Putting memories in their place

Chia-Hsuan Wang, Thomas J. McHugh
https://doi.org/10.1038/s41422-022-00737-4
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Adaptation to MOMP drives cancer persistence

Emma Guilbaud, Lorenzo Galluzzi
https://doi.org/10.1038/s41422-022-00729-4
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A structural platform for B cell receptor signaling

Wei Xie, Kai Wucherpfennig, Dinshaw J. Patel
https://doi.org/10.1038/s41422-022-00724-9
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REVIEW ARTICLE

RBP–RNA interactions in the control of autoimmunity and autoinflammation

Juan Liu, Xuetao Cao
https://doi.org/10.1038/s41422-022-00752-5
Full Text | PDF | Abstract | Open Access


ORIGINAL ARTICLES

LilrB3 is a putative cell surface receptor of APOE4

Jiayao Zhou, Yumeng Wang, Gaoxingyu Huang, Min Yang, Yumin Zhu, Chen Jin, Dan Jing, Kai Ji, Yigong Shi
https://doi.org/10.1038/s41422-022-00759-y
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Autoinhibitory structure of preligand association state implicates a new strategy to attain effective DR5 receptor activation

Gang Du, Linlin Zhao, Yumei Zheng, Anissa Belfetmi, Tiantian Cai, Boying Xu, Karen Heyninck, Kim Van Den Heede, Marie-Ange Buyse, Pietro Fontana, Lih-Ling Lin, Hao Wu, James Jeiwen Chou
https://doi.org/10.1038/s41422-022-00755-2
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Human endoderm stem cells reverse inflammation-related acute liver failure through cystatin SN-mediated inhibition of interferon signaling

Yilin Xu, Jinglin Wang, Haozhen Ren, Hao Dai, Ying Zhou, Xiongzhao Ren, Yang Wang, Sisi Feng, Xiaogang Deng, Jiaying Wu, Tianlong Fu, Tengfei Nie, Haifeng He, Tongkun Wei, Bing Zhu, Lijian Hui, Bin Li, Jing Wang, Hongyan Wang, Luonan Chen, Xiaolei Shi, Xin Cheng
https://doi.org/10.1038/s41422-022-00760-5
Full Text | PDF | Abstract | Open Access


Two target gene activation pathways for orphan ERR nuclear receptors

Tomoyoshi Nakadai, Miho Shimada, Keiichi Ito, Murat Alper Cevher, Chi-Shuen Chu, Kohei Kumegawa, Reo Maruyama, Sohail Malik, Robert G Roeder
https://doi.org/10.1038/s41422-022-00774-z
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LETTERS TO THE EDITOR

Molecular recognition of itch-associated neuropeptides by bombesin receptors

Changyao Li, Youwei Xu, Heng Liu, Hongmin Cai, Yi Jiang, H. Eric Xu, Wanchao Yin
https://doi.org/10.1038/s41422-022-00743-6
Full Text | PDF | Abstract | Open Access