RESEARCH HIGHLIGHTS

mTOR gets greasy: lysosomal sensing of cholesterol

Liron Bar-Peled, Dudley W. Lamming
https://doi.org/10.1038/s41422-022-00740-9
Full Text | PDF | Abstract

Buckle up! How the nano-seatbelt MRAP1 fastens ACTH in its orthosteric seat

Daniel Hilger
https://doi.org/10.1038/s41422-022-00767-y
Full Text | PDF | Abstract

Objection non-responsive! How maternal immune activation in pregnancy weakens subsequent microglial immune response

Thomas Blank, Marco Prinz
https://doi.org/10.1038/s41422-022-00756-1
Full Text | PDF | Abstract

An exploitable Achilles heel of MITF?

Carolina Silva, Ze’ev A. Ronai
https://doi.org/10.1038/s41422-022-00762-3
Full Text | PDF | Abstract

Immune checkpoint inhibitors as senolytic agents

Parminder Singh, Pankaj Kapahi, Jan M. van Deursen
https://doi.org/10.1038/s41422-022-00761-4
Full Text | PDF | Abstract

Death receptor 5 rises to the occasion

Lixin Zheng, Yikun Yao, Michael J. Lenardo
https://doi.org/10.1038/s41422-022-00772-1
Full Text | PDF | Abstract

ORIGINAL ARTICLES

SARS-CoV-2 Z-RNA activates the ZBP1-RIPK3 pathway to promote virus-induced inflammatory responses

Shufen Li, Yulan Zhang, Zhenqiong Guan, Meidi Ye, Huiling Li, Miaomiao You, Zhenxing Zhou, Chongtao Zhang, Fan Zhang, Ben Lu, Peng Zhou, Ke Peng
https://doi.org/10.1038/s41422-022-00775-y
Full Text | PDF | Abstract

Targeting ATAD3A-PINK1-mitophagy axis overcomes chemoimmunotherapy resistance by redirecting PD-L1 to mitochondria

Xiao-Qing Xie, Yi Yang, Qiang Wang, Hao-Fei Liu, Xuan-Yu Fang, Cheng-Long Li, Yi-Zhou Jiang, Shuai Wang, Hong-Yu Zhao, Jing-Ya Miao, Shuai-Shuai Ding, Xin-Dong Liu, Xiao-Hong Yao, Wen-Tao Yang, Jun Jiang, Zhi-Ming Shao, Guoxiang Jin, Xiu-Wu Bian
https://doi.org/10.1038/s41422-022-00766-z
Full Text | PDF | Abstract | Open Access

The compact Casπ (Cas12l) ‘bracelet’ provides a unique structural platform for DNA manipulation

Ao Sun, Cheng-Ping Li, Zhihang Chen, Shouyue Zhang, Dan-Yuan Li, Yun Yang, Long-Qi Li, Yuqian Zhao, Kaichen Wang, Zhaofu Li, Jinxia Liu, Sitong Liu, Jia Wang, Jun-Jie Gogo Liu
https://doi.org/10.1038/s41422-022-00771-2
Full Text | PDF | Abstract

Fructose-1,6-bisphosphatase 1 dephosphorylates IκBα and suppresses colorectal tumorigenesis

Wencheng Zhu, Huiying Chu, Yajuan Zhang, Tianhang Luo, Hua Yu, Hongwen Zhu, Ye Liu, Hong Gao, Yun Zhao, Quanlin Li, Xiongjun Wang, Guohui Li, Weiwei Yang
https://doi.org/10.1038/s41422-022-00773-0
Full Text | PDF | Abstract

LETTERS TO THE EDITOR

Repeated vaccination of inactivated SARS-CoV-2 vaccine dampens neutralizing antibodies against Omicron variants in breakthrough infection

Bo Gao, Liheng He, Yujie Bao, Yingying Chen, Guanzhu Lu, Yu Zhang, Yingjie Xu, Bing Su, Jie Xu, Ying Wang, Leng-Siew Yeap
https://doi.org/10.1038/s41422-023-00781-8
Full Text | PDF | Abstract